INT16236

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 19.59
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
blood 2
plasma 1
VOD 1
cerebrospinal fluid 1
neural 1
CFH (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 3 99.70 Very High Very High Very High
anesthesia 9 99.44 Very High Very High Very High
postherpetic neuralgia 13 99.32 Very High Very High Very High
metalloproteinase 3 98.42 Very High Very High Very High
cytokine 52 97.84 Very High Very High Very High
Angina 2 96.84 Very High Very High Very High
Pain 11 92.72 High High
lidocaine 2 87.80 High High
ganglionectomy 66 87.20 High High
cINOD 3 86.44 High High
Disease Link Frequency Relevance Heat
Recurrence 111 100.00 Very High Very High Very High
Myocardial Infarction 111 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 67 100.00 Very High Very High Very High
Herpes Zoster 15 100.00 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 14 99.96 Very High Very High Very High
Pressure Volume 2 Under Development 60 99.76 Very High Very High Very High
Post Operative Pain 13 99.32 Very High Very High Very High
Diarrhoea 6 99.28 Very High Very High Very High
Renal Disease 32 99.24 Very High Very High Very High
Ectopic Pregnancy 6 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, a newly identified vasodilatory peptide, namely adrenomedullin, which is depressed after severe blood loss because of downregulation of adrenomedullin binding protein (AMBP)-1 [137], acts as a circulating hormone that elicits various biologic activities in a paracrine and autocrine manner.
Negative_regulation (downregulation) of AMBP in blood associated with pressure volume 2 under development
1) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 0.73 Pain Relevance 0.06
Variety of genetic forms include HUS due to deficiencies of factor H, membrane cofactor protein, Von Willebrand factor-cleaving protease (ADAMTS 13) and intracellular defect in vitamin B12 metabolism.
Negative_regulation (deficiencies) of factor H in B12 associated with hemolytic uremic syndrome
2) Confidence 0.56 Published 2006 Journal Nephrology (Carlton) Section Abstract Doc Link 16756634 Disease Relevance 1.91 Pain Relevance 0.09
A brief account of the expectant treatment of patients with nonviable ectopic pregnancy is given, underlining the prerequisites of decreasing beta-hCG values and the absence of fluid in the pouch of Douglas.
Negative_regulation (decreasing) of beta-hCG associated with ectopic pregnancy
3) Confidence 0.44 Published 1991 Journal Curr. Opin. Obstet. Gynecol. Section Abstract Doc Link 1813010 Disease Relevance 0.51 Pain Relevance 0.13
Therapeutic plasma exchange is a promising treatment for adults who develop HUS/TTP, but its role has yet to be determined definitively, either in a randomized controlled trial or by an international register of cases.
Negative_regulation (develop) of HUS in plasma associated with hemolytic uremic syndrome and thrombotic thrombocytopenic purpura
4) Confidence 0.41 Published 2000 Journal Symp Ser Soc Appl Microbiol Section Abstract Doc Link 10880176 Disease Relevance 1.20 Pain Relevance 0.08
RESULT(S): Expected decline in beta human chorionic gonadotropin (beta-hCG) levels without the need for any further intervention(s).
Negative_regulation (decline) of beta-hCG
5) Confidence 0.38 Published 2009 Journal Fertil. Steril. Section Body Doc Link 19819446 Disease Relevance 0.19 Pain Relevance 0
In a panel of 100 normal control individuals, MLPA showed no evidence of a deletion of CFH exons 22 and 23.


Negative_regulation (deletion) of CFH
6) Confidence 0.38 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
In adult-onset HUS the recurrence rate reduces graft survival, particularly among patients undergoing second transplantation.
Negative_regulation (reduces) of HUS associated with hemolytic uremic syndrome and recurrence
7) Confidence 0.37 Published 2006 Journal Transplant. Proc. Section Abstract Doc Link 16757250 Disease Relevance 0.96 Pain Relevance 0.09
In contrast, in middle-aged and older patients, the LF/HF decreased during local anesthesia.
Negative_regulation (decreased) of HF associated with anesthesia
8) Confidence 0.35 Published 1998 Journal Am. J. Hypertens. Section Abstract Doc Link 9832183 Disease Relevance 0.31 Pain Relevance 0.36
Administration of local anesthetic significantly decreased the %HF in normotensive patients (before vs. after anesthesia; 22.3 +/- 2.4 vs. 13.8 +/- 2.7%, p < 0.05).
Negative_regulation (decreased) of HF associated with anesthesia and local anesthetic
9) Confidence 0.35 Published 2000 Journal Hypertens. Res. Section Abstract Doc Link 10821128 Disease Relevance 0.53 Pain Relevance 0.28
In young patients (<40 years old), the %HF decreased and the LF/HF increased during local anesthesia.
Negative_regulation (decreased) of HF associated with anesthesia
10) Confidence 0.35 Published 1998 Journal Am. J. Hypertens. Section Abstract Doc Link 9832183 Disease Relevance 0.31 Pain Relevance 0.36
In patients receiving radiation for conditioning, intravenous immune globulin decreased VOD risk (RR 0.26; P = 0.003).
Negative_regulation (decreased) of immune globulin in VOD
11) Confidence 0.32 Published 1996 Journal Bone Marrow Transplant. Section Abstract Doc Link 8673059 Disease Relevance 0.87 Pain Relevance 0.07
The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria.
Negative_regulation (prevent) of HUS associated with hemolytic uremic syndrome and infection
12) Confidence 0.29 Published 2005 Journal Lancet Section Abstract Doc Link 15781103 Disease Relevance 1.09 Pain Relevance 0.09
It was reported that the aged mice genetically deficient in CFH (cfh?
Negative_regulation (deficient) of CFH
13) Confidence 0.23 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.61 Pain Relevance 0
This alternative pathway activation was due to the decrease in CFH levels and increase in CFB levels in the RPE/choroid after laser treatment [94].
Negative_regulation (decrease) of CFH in choroid
14) Confidence 0.23 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.75 Pain Relevance 0
Very few patients with factor B or C3 mutation but no factor H deficiency have undergone Tx, but, again, the risk of recurrence seems to be rather high [5, 6].
Neg (no) Negative_regulation (deficiency) of factor H associated with recurrence
15) Confidence 0.15 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 0.96 Pain Relevance 0
Matrix metalloproteinases (MMPs) constitute a family of matrix degrading enzymes that contribute to the development of HF [42].
Negative_regulation (development) of HF associated with metalloproteinase and myocardial infarction
16) Confidence 0.14 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.39 Pain Relevance 0.05
In contrast, a newly identified vasodilatory peptide, namely adrenomedullin, which is depressed after severe blood loss because of downregulation of adrenomedullin binding protein (AMBP)-1 [137], acts as a circulating hormone that elicits various biologic activities in a paracrine and autocrine manner.
Negative_regulation (downregulation) of adrenomedullin binding protein in blood associated with pressure volume 2 under development
17) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 0.72 Pain Relevance 0.06
Nevertheless, substantial evidence for a neural origin for RSA was provided by animal and human studies that showed marked reduction of HF activity after parasympathetic blockade [1,11,17,39].
Negative_regulation (reduction) of HF in neural associated with sinus arrhythmia
18) Confidence 0.08 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.36 Pain Relevance 0
This finding was due to a marked increase in LF area accompanied by a decrease of HF area of similar magnitude (Fig. 3B, top and middle graphs).
Negative_regulation (decrease) of HF
19) Confidence 0.08 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.08 Pain Relevance 0.13
The beneficial effect of adrenomedullin/AMBP-1 is associated with downregulation of endothelin-1, which is normally upregulated in hemorrhagic shock [140].
Negative_regulation (effect) of AMBP-1 associated with hemorrhagic shock
20) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2575549 Disease Relevance 1.16 Pain Relevance 0.09

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