INT162361

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.44
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 2
brain 2
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 24 100.00 Very High Very High Very High
Inflammation 2 97.36 Very High Very High Very High
Pain 2 95.84 Very High Very High Very High
potassium channel 31 94.84 High High
Dismenorea 5 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 99.92 Very High Very High Very High
Breast Cancer 2 99.84 Very High Very High Very High
Coagulation Disorder 2 99.16 Very High Very High Very High
Metastasis 1 98.88 Very High Very High Very High
Endotoxemia 2 98.44 Very High Very High Very High
Hypertension 2 97.92 Very High Very High Very High
INFLAMMATION 2 97.36 Very High Very High Very High
Pain 2 95.84 Very High Very High Very High
Disease 1 94.56 High High
Prostate Cancer 11 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KCNMA1 expression was found to be higher in breast tumors and brain metastases [50].
Positive_regulation (higher) of Gene_expression (expression) of KCNMA1 in brain associated with breast cancer and metastasis
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.17 Pain Relevance 0
subunit mRNA expression, the increased proportion of Maxi-K ?
Positive_regulation (increased) of Gene_expression (expression) of Maxi-K
2) Confidence 0.44 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Expression of this variant mRNA accounted for only 1% of total Maxi-K ?
Positive_regulation (accounted) of Gene_expression (Expression) of Maxi-K
3) Confidence 0.36 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Systemic production of BK, HKa with the interplay between BK bound-BK receptors and the soluble form of HKa are key to angiogenesis and hemodynamics.
Positive_regulation (bound) of Gene_expression (production) of BK associated with bradykinin
4) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.57 Pain Relevance 0.57
In all these cases increased BK levels is the hallmark.
Positive_regulation (increased) of Gene_expression (levels) of BK associated with bradykinin
5) Confidence 0.05 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.64 Pain Relevance 0.60
Increased TREK-1 channel expression as well as function in pregnant myometrium suggests that as pregnancy progresses and the stretch of the uterus increases, these K2P channels are activated to assist in the maintenance of relaxation.
Positive_regulation (Increased) of Gene_expression (expression) of channel in myometrium associated with potassium channel
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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