INT162366

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 15.69
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Anatomy Link Frequency
macrophages 2
immune cell 1
adipose tissue 1
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 85 99.84 Very High Very High Very High
cytokine 665 99.28 Very High Very High Very High
Inflammation 448 99.16 Very High Very High Very High
Acupuncture 105 92.36 High High
Inflammatory mediators 34 85.20 High High
Pain 126 79.36 Quite High
rheumatoid arthritis 1 76.96 Quite High
Pain threshold 35 5.00 Very Low Very Low Very Low
transcutaneous nerve stimulation 25 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1806 99.84 Very High Very High Very High
INFLAMMATION 566 99.84 Very High Very High Very High
Apoptosis 6 99.00 Very High Very High Very High
Shock 2 98.98 Very High Very High Very High
Insulin Resistance 170 97.08 Very High Very High Very High
Necrosis 51 88.64 High High
Cancer 85 88.28 High High
Autoimmune Disease 1 82.56 Quite High
Metabolic Syndrome 16 80.72 Quite High
Pain 161 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increased Tpl2 mRNA and restored or even increased the pool of Tpl2 protein.
Positive_regulation (increased) of Tpl2
1) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.74 Pain Relevance 0.16
increased Tpl2 mRNA and restored or even increased the pool of Tpl2 protein.
Positive_regulation (increased) of Tpl2 protein
2) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.73 Pain Relevance 0.16
These data strongly support an activation of Tpl2, because Tpl2 degradation by the proteasome is tightly coupled to its activation in macrophages (29,30).
Positive_regulation (activation) of Tpl2 in macrophages
3) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.65 Pain Relevance 0.16
increased Tpl2 mRNA and restored or even increased the pool of Tpl2 protein.
Positive_regulation (restored) of Tpl2
4) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.74 Pain Relevance 0.16
Among the MAP3Ks that regulate the ERK pathway, Tpl2 is more specifically activated by inflammatory stimuli (26,32).
Positive_regulation (activated) of Tpl2 associated with inflammatory stimuli
5) Confidence 0.50 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.85 Pain Relevance 0.26
Cot/Tpl-2 kinase activation plays an integral role in the production of pro-inflammatory cytokines such as TNF and IL-1beta in this immune cell type.
Positive_regulation (activation) of Cot/Tpl-2 in immune cell associated with inflammation and cytokine
6) Confidence 0.45 Published 2009 Journal Curr Top Med Chem Section Abstract Doc Link 19689369 Disease Relevance 0.61 Pain Relevance 0.33
One important finding of our study is that Tpl2 was not required for the activation of ERK or PKB pathways by insulin.
Neg (not) Positive_regulation (required) of Tpl2
7) Confidence 0.36 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.73 Pain Relevance 0.28
According to this pattern one were supposed to have reduced EST, (from 3 to 2), and three of them that were supposed to report increased EST, from 4 to 5 and 6 to 7 respectively, after EA as compared with before EA.


Positive_regulation (increased) of EST
8) Confidence 0.36 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0.06 Pain Relevance 0.11
Tpl2 mRNA level is increased in adipose tissue of obese mice and subjects.
Positive_regulation (increased) of Tpl2 in adipose tissue associated with obesity
9) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.21 Pain Relevance 0.10
By using both pharmacological and siRNA approaches, we showed that Tpl2 activation was required for cytokine-induced lipolysis.
Positive_regulation (activation) of Tpl2 associated with cytokine
10) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.69 Pain Relevance 0.35
(18 h) increased Tpl2 protein amount by threefold, whereas TNF-?
Positive_regulation (increased) of Tpl2 protein
11) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.40 Pain Relevance 0.09
activated Tpl2 and regulated its expression through an IKK?
Positive_regulation (activated) of Tpl2
12) Confidence 0.34 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797946 Disease Relevance 1.64 Pain Relevance 0.37
B pathway is involved in the upregulation of Tpl2 mRNA, whereas IKK?
Positive_regulation (upregulation) of Tpl2
13) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.58 Pain Relevance 0.10
Thus, inflammation linked to obesity could promote both the activation of Tpl2 that is coupled to its rapid degradation and the stimulation of Tpl2 gene transcription.
Positive_regulation (activation) of Tpl2 associated with inflammation and obesity
14) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.68 Pain Relevance 0.11
treatment for 18 h increased Tpl2 mRNA level by 7.9- and 2.7-fold, respectively (Fig. 7B).
Positive_regulation (increased) of Tpl2
15) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 1.21 Pain Relevance 0.08
The increase in Tpl2 mRNA level was prevented by both IKK?
Positive_regulation (increase) of Tpl2
16) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.15
Indeed, in nonstimulated macrophages, Tpl2 is stabilized and is inactive due to its binding to NF-?
Positive_regulation (stabilized) of Tpl2 in macrophages
17) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.08
Similarly, Tpl2 is dispensable for ERK activation induced by phorbol myristate acetate (PMA) (29).
Positive_regulation (activation) of Tpl2
18) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.72 Pain Relevance 0.32
increased Tpl2 mRNA and restored or even increased the pool of Tpl2 protein.
Positive_regulation (increased) of Tpl2
19) Confidence 0.34 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.74 Pain Relevance 0.16
The difference in proportions in women and men who reported EST increase was -39% (95%CI, -23% to -62%), i.e. a greater EST increase was reported by the men than the women after EA.
Positive_regulation (increase) of EST
20) Confidence 0.24 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.03

General Comments

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