INT162367

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.09
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8)
cytoplasm (Map3k8)
Map3k8 (Mus musculus)
Pain Link Frequency Relevance Heat
Acupuncture 84 99.84 Very High Very High Very High
Inflammation 58 99.84 Very High Very High Very High
Serotonin 1 98.84 Very High Very High Very High
rheumatoid arthritis 1 91.84 High High
Pain 103 90.00 High High
cytokine 42 87.76 High High
Inflammatory stimuli 5 72.00 Quite High
Pain threshold 28 44.60 Quite Low
Paresthesia 4 42.60 Quite Low
Inflammatory mediators 4 29.44 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 69 99.84 Very High Very High Very High
Cancer 9 99.58 Very High Very High Very High
Disease 5 98.16 Very High Very High Very High
Shock 2 93.40 High High
Rheumatoid Arthritis 1 91.84 High High
Pain 132 90.00 High High
Autoimmune Disease 1 89.00 High High
Adhesions 1 87.66 High High
Obesity 106 86.52 High High
Apoptosis 3 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, we cannot exclude that another kinase in addition to Tpl2 is involved in ERK activation.
Regulation (involved) of Tpl2
1) Confidence 0.33 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.60 Pain Relevance 0.24
This review will describe the physiological regulation and importance of Cot/Tpl-2 in inflammation as well as the landscape of small molecules that have been reported as Cot/Tpl-2 inhibitors.
Regulation (regulation) of Cot/Tpl-2 associated with inflammation
2) Confidence 0.26 Published 2009 Journal Curr Top Med Chem Section Abstract Doc Link 19689369 Disease Relevance 0.70 Pain Relevance 0.35
The pattern of changes in the paired data of EST and EPT, before and ten minutes after EA, were shown in square contingency tables, and in scatter plots respectively.
Regulation (changes) of EST
3) Confidence 0.23 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.06
According to the calculated RTPC for the women in this study, the expected EST after EA is unaffected by acupuncture stimulation in the ST36 and ST38 except for four of the women.
Neg (unaffected) Regulation (unaffected) of EST associated with acupuncture
4) Confidence 0.23 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0.05
The hypotheses of no change in assessed EST and EPT comparing values before and after EA were analyzed by the non-parametric sign test.
Regulation (values) of EST
5) Confidence 0.14 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0
The hypotheses of no change in assessed EST and EPT comparing values before and after EA were analyzed by the non-parametric sign test.
Neg (no) Regulation (change) of EST
6) Confidence 0.14 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0 Pain Relevance 0
Overall NK1R-dependent genes were classified following the biological processes with which they are involved (GO anthology): apoptosis (GZMA, TNFRSF1B, TNFRSF1A, TRAF3, NOS2A, and BID); cell adhesion/hyaluronic acid binding (CD44 and AGC1); cell cycle (CCND2 and CCNG1); cell-cell signaling (FGF11 and GJA7); cytokinesis (CDC42 and KIF1B); development (FMR2); extracellular transporters & carriers (APOE); G-protein coupled receptors (GNA13 and PTGIR); growth factors (MXD1); heat shock proteins (PRNP, HSPH1, and HSPD1); immune response (BST-1, CTSW, and IL1R1); interferons (INFGR1) intracellular kinases (WBP6); intracellular transducers (MAP3K7); kinase activators & inhibitors (YWHAH); membrane channels (KCNAB1, KCNJ12, KCNQ1, and SLC30A4); nucleotide metabolism (PCSK1); oncogenes & tumor suppressors (BRCA1, MAP3K8, RET, VIL2, FLI1, MET, NF2, and VEGFR1); receptor mediated endocytosis (DAB2); receptor tyrosine kinase (EPHA2); regulation of transcription (NEUROD6); serotonin biosynthesis (YTPH1); symporters & antiporters (SLC16A1 and SLC1A1); transcription activators & repressors (FOXA1, HSF1, IER2, and NR1H2); and synaptic transmission (GRID1).


Regulation (regulation) of MAP3K8 associated with cancer, shock, apoptosis, serotonin and adhesions
7) Confidence 0.06 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.79 Pain Relevance 0.11

General Comments

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