INT162372

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.80
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPD) extracellular region (SFTPD) lysosome (SFTPD)
Anatomy Link Frequency
lung 2
synovial fluid 1
SFTPD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 440 99.84 Very High Very High Very High
corticosteroid 14 99.84 Very High Very High Very High
cytokine 19 98.76 Very High Very High Very High
lidocaine 1 98.28 Very High Very High Very High
Inflammation 186 95.60 Very High Very High Very High
Inflammatory mediators 2 91.80 High High
chemokine 4 90.68 High High
Inflammatory response 16 79.88 Quite High
methotrexate 72 78.88 Quite High
local anesthetic 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 100.00 Very High Very High Very High
Nicotine Addiction 106 99.98 Very High Very High Very High
Rheumatoid Arthritis 440 99.84 Very High Very High Very High
Pulmonary Disease 25 99.56 Very High Very High Very High
Disease 230 99.24 Very High Very High Very High
Pulmonary Alveolar Proteinosis 102 98.92 Very High Very High Very High
Non-small-cell Lung Cancer 38 96.00 Very High Very High Very High
INFLAMMATION 168 95.60 Very High Very High Very High
Arthritis 40 94.56 High High
Apoptosis 16 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, SP-D increased significantly with age in healthy subjects (rho = 0.21, P < 0.001), and control males had significantly higher levels of SP-D compared to females (Table 2).
Positive_regulation (levels) of SP-D
1) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.11 Pain Relevance 0.28
It has previously been demonstrated that smoking increases SP-D in serum [22].
Positive_regulation (increases) of SP-D associated with nicotine addiction
2) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.27 Pain Relevance 0.39
Such a scavenger mechanism for SP-D in RA is supported by the inverse association between SP-D and disease activity measures and by the gradual SP-D increase during treatment.
Positive_regulation (increase) of SP-D associated with rheumatoid arthritis and disease
3) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.93 Pain Relevance 0.33
Besides EGFR mutations, the favorable PFS after gefitinib treatment was also associated with high levels of serum surfactant protein D (SP-D) [27].
Positive_regulation (levels) of SP-D
4) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2954881 Disease Relevance 1.40 Pain Relevance 0.03
In contrast, SP-D increased significantly with age in healthy subjects (rho = 0.21, P < 0.001), and control males had significantly higher levels of SP-D compared to females (Table 2).
Positive_regulation (increased) of SP-D
5) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.00 Pain Relevance 0.29
Multimeric SP-D was barely detectable in synovial fluid as compared to serum, where both multimeric and trimeric molecular variant SP-D (trimeric subunits) were detected.


Positive_regulation (Multimeric) of SP-D in synovial fluid
6) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.40 Pain Relevance 0.14
Although SP-D increased significantly during follow-up, it remained subnormal at four years.
Positive_regulation (increased) of SP-D
7) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 1.08 Pain Relevance 0.33
SP-D increased slightly during follow-up (P < 0.001), but was still subnormal at four years after adjustment for confounders (P < 0.001).
Positive_regulation (increased) of SP-D
8) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888186 Disease Relevance 0.86 Pain Relevance 0.36
Compared to baseline, SP-D had increased in RA patients at four years (893 ng/ml [810; 1013] vs. 693 ng/ml [649; 770], P < 0.001) even when adjusting for gender, age and smoking status (p < 0.001).
Positive_regulation (increased) of SP-D associated with nicotine addiction and rheumatoid arthritis
9) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888186 Disease Relevance 0.86 Pain Relevance 0.30
We previously showed that intracellular SP-D mRNA and protein expression are very sensitive to corticosteroids, cAMP, and cytokine levels (Cao et al. 2004) and that SP-D in broncho-alveolar lavage fluid is subject to rapid break-down after O3 exposure of mice (Kierstein et al. 2006).
Positive_regulation (sensitive) of SP-D associated with corticosteroid and cytokine
10) Confidence 0.12 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.47 Pain Relevance 0.32
Although no formal comparisons have been made between local (pulmonary) expression of SP-D and CCP16, we speculate that the CCP16 molecule is more resistant to O3-induced breakdown than is SP-D.
Positive_regulation (induced) of SP-D
11) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.39 Pain Relevance 0.27
Finally, an increased serum SP-D level predicted the occurrence of PAP in the sister, which was confirmed by subsequent clinical and radiographical evaluation.
Positive_regulation (increased) of SP-D associated with pulmonary alveolar proteinosis
12) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.83 Pain Relevance 0
Because SP is in serum in PAP and levels reflect lung disease severity (25), serum SP-D was measured and found to be increased in the patient compared with her parents and controls (Fig. 1 D).
Positive_regulation (increased) of SP-D in lung associated with pulmonary disease and pulmonary alveolar proteinosis
13) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.45 Pain Relevance 0
Unexpectedly, the patient's 8-yr-old sister, who was previously thought to be healthy, had increased serum SP-D.
Positive_regulation (increased) of SP-D
14) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.38 Pain Relevance 0
Both lidocaine and mepivacaine attenuate the increase of pulmonary arterial pressure (PAP) and lung edema development.
Positive_regulation (increase) of pulmonary arterial pressure in lung associated with pressure and volume under development
15) Confidence 0.00 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19690261 Disease Relevance 0.37 Pain Relevance 0.17

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