INT162380

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.98
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCR2) plasma membrane (CXCR2) intracellular (CXCR2)
signal transducer activity (CXCR2)
Anatomy Link Frequency
macrophage 3
neutrophil 1
CXCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 145 100.00 Very High Very High Very High
cytokine 69 100.00 Very High Very High Very High
Inflammatory response 11 100.00 Very High Very High Very High
abatacept 242 99.98 Very High Very High Very High
rheumatoid arthritis 195 97.04 Very High Very High Very High
metalloproteinase 7 93.52 High High
Inflammation 123 89.44 High High
Inflammatory marker 6 73.56 Quite High
imagery 2 70.72 Quite High
Inflammatory mediators 8 70.36 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 178 100.00 Very High Very High Very High
INFLAMMATION 143 100.00 Very High Very High Very High
Cancer 105 99.84 Very High Very High Very High
Atherosclerosis 46 99.04 Very High Very High Very High
Rheumatoid Arthritis 198 97.04 Very High Very High Very High
Lung Injury 18 96.64 Very High Very High Very High
Atherosclerotic Plaque 8 96.56 Very High Very High Very High
Adhesions 8 96.08 Very High Very High Very High
Necrosis 12 92.80 High High
Disease Progression 10 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In the microarray analysis of hip drain neutrophils, interleukin-1 receptor antagonist (IL1RN), interleukin-18 receptor 1 (IL18R1), macrophage migration inhibitory factor (MIF), and macrophage inflammatory protein 3alpha (CCL20) were upregulated, whereas interleukin-8 receptor beta (IL8RB/CXCR2) was consistently downregulated, compared with presurgery blood neutrophils.
Negative_regulation (downregulated) of CXCR2 in macrophage
1) Confidence 0.57 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.06 Pain Relevance 0
RESULTS: In the microarray analysis of hip drain neutrophils, interleukin-1 receptor antagonist (IL1RN), interleukin-18 receptor 1 (IL18R1), macrophage migration inhibitory factor (MIF), and macrophage inflammatory protein 3alpha (CCL20) were upregulated, whereas interleukin-8 receptor beta (IL8RB/CXCR2) was consistently downregulated, compared with presurgery blood neutrophils.
Negative_regulation (downregulated) of interleukin-8 receptor beta in macrophage
2) Confidence 0.43 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.06 Pain Relevance 0
The genotype distribution and allele frequencies for the IL-8 (-251) T/A and CXCR2 (+1208) C/T polymorphisms in all breast carcinoma patients and controls are presented in Table 4.
Negative_regulation (presented) of CXCR2 associated with breast cancer
3) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 0.99 Pain Relevance 0
RESULTS: In the microarray analysis of hip drain neutrophils, interleukin-1 receptor antagonist (IL1RN), interleukin-18 receptor 1 (IL18R1), macrophage migration inhibitory factor (MIF), and macrophage inflammatory protein 3alpha (CCL20) were upregulated, whereas interleukin-8 receptor beta (IL8RB/CXCR2) was consistently downregulated, compared with presurgery blood neutrophils.
Negative_regulation (downregulated) of IL8RB in macrophage
4) Confidence 0.42 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690273 Disease Relevance 0.06 Pain Relevance 0
The expression of IL-8 and the receptor of ELR+CXC chemokine CXCR2 in cancer have been evaluated in numerous studies.
Negative_regulation (receptor) of ELR+CXC chemokine CXCR2 associated with chemokine and cancer
5) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2895614 Disease Relevance 1.38 Pain Relevance 0.22
The chemokine receptor genes were differentially expressed, with upregulation of CXCR4, CCRL2 and CCR5 and downregulation of CXCR1 and CXCR2.
Negative_regulation (downregulation) of CXCR2 associated with chemokine
6) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.62 Pain Relevance 0.35
CXCR2 deficiency retards progression of atherosclerosis in animal models [82].
Negative_regulation (deficiency) of CXCR2 associated with atherosclerosis
7) Confidence 0.21 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.38 Pain Relevance 0.27
For many other receptors, particularly the neutrophil receptors CXCR1 and CXCR2, mRNA levels were downregulated.
Negative_regulation (downregulated) of CXCR2 in neutrophil
8) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.46 Pain Relevance 0.50
We also tested nicotinanilide thioglycolate methyl ester (NTME), a CXCR2 inhibitor, to block IL-8 signaling.
Negative_regulation (inhibitor) of CXCR2
9) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC2978154 Disease Relevance 1.28 Pain Relevance 0.38
At the doses of 2 mg/kg or 10 mg/kg used in further clinical studies, abatacept decreased serum levels of proinflammatory cytokines and inflammatory responses, including soluble IL-2 receptor, IL-6, E-selectin, TNF-alfa, rheumatoid factor, and C-reactive protein levels (Weisman et al. 2006).
Negative_regulation (decreased) of IL-2 receptor associated with inflammatory response, abatacept and cytokine
10) Confidence 0.04 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.53 Pain Relevance 0.64
Evaluation of biomarkers in patients recruited as part of the AIM and ATTAIN studies confirmed an effective cellular action [42]; specifically, reductions in rheumatoid factor, CRP, soluble IL-2 receptor, IL-6, TNF-?
Negative_regulation (reductions) of IL-2 receptor
11) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.15 Pain Relevance 0.40

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