INT16239

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.06
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Trf) transport (Trf) mitochondrion (Trf)
extracellular space (Trf) extracellular region (Trf) cytoplasmic membrane-bounded vesicle (Trf)
Anatomy Link Frequency
plasma 2
blood 1
Trf (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 100.00 Very High Very High Very High
Chronic pancreatitis 8 99.44 Very High Very High Very High
alcohol 2 92.48 High High
ischemia 1 90.52 High High
anesthesia 11 90.08 High High
Inflammation 21 85.60 High High
analgesia 1 68.64 Quite High
imagery 12 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 100.00 Very High Very High Very High
Stress 18 99.80 Very High Very High Very High
Pancreatitis 17 99.44 Very High Very High Very High
Chronic Renal Failure 65 99.18 Very High Very High Very High
Pancreatic Cancer 6 98.28 Very High Very High Very High
Coronary Artery Disease 5 90.52 High High
Heart Rate Under Development 5 86.80 High High
INFLAMMATION 21 85.60 High High
Scrapie 26 79.80 Quite High
Liver Disease 1 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We considered that radiation therapy in this patient with chronic renal failure evoked marked oxidative stress and that deficiency of transferrin played an important role in peroxidative cell damage.
Negative_regulation (deficiency) of transferrin associated with stress and chronic renal failure
1) Confidence 0.32 Published 1995 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 7699960 Disease Relevance 1.04 Pain Relevance 0.13
Nonetheless, we observed that, similar to control ScGT1 cells, Tfn could not be detected inside the cells after a 45 minutes chase period (compare panels c and d in Figure 3), indicating that under these conditions Tfn recycling to the surface via EEs was unaffected.
Negative_regulation (unaffected) of Tfn
2) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.05 Pain Relevance 0
In U18666A-treated cells Tfn delivery to the ERC was inhibited (Figure 3B) but its recycling to the surface from EEs was unaffected (Figures 3C and 3D).
Negative_regulation (inhibited) of Tfn
3) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0
For example, the plasma concentration of transferrin, one of the main plasma proteins, was decreased due to Dll1 haploinsufficiency.
Negative_regulation (decreased) of transferrin in plasma
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.28 Pain Relevance 0
Intravenous ascorbic acid therapy facilitates iron release from inert deposits, resulting in a decrease of soluble transferrin receptor and an increase of TSAT [88].
Negative_regulation (decrease) of transferrin
5) Confidence 0.10 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.55 Pain Relevance 0.04
An assessment of the influence of several variables during the perioperative period revealed a cause-determining correlation between the explanatory variables age, body size, weight, duration of operation, loss of blood, and pain level and the physiologic variables adrenaline, total protein, blood glucose level, transferrin, cholinesterase and immunoglobulin G that could be statistically be proven.
Negative_regulation (loss) of transferrin in blood associated with pain
6) Confidence 0.09 Published 1991 Journal Klin. Wochenschr. Section Abstract Doc Link 1813703 Disease Relevance 0.23 Pain Relevance 0.57
In CP, transthyretin levels were decreased in 37%, transferrin in 27%, and albumin in 12% of patients.
Negative_regulation (decreased) of transferrin associated with chronic pancreatitis
7) Confidence 0.05 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553437 Disease Relevance 1.34 Pain Relevance 0.61
However, serum transferrin saturation percent was statistically significantly decreased in Jeddah firefighters as compared to Yanbu firefighters, (p < 0.05) as shown in table 6.
Negative_regulation (decreased) of transferrin
8) Confidence 0.04 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2713944 Disease Relevance 0 Pain Relevance 0
High-abundance plasma proteins (albumin, transferrin, haptoglobin, alpha-1-antitrypsin, IgG and IgA) were depleted by use of an immuno-affinity column, and low-abundance ones were separated into five fractions by anion-exchange chromatography.
Negative_regulation (depleted) of transferrin in plasma
9) Confidence 0.01 Published 2007 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 17303479 Disease Relevance 0.44 Pain Relevance 0

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