INT162393

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 58
Total Number 60
Disease Relevance 38.78
Pain Relevance 7.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMUG1) hydrolase activity, acting on glycosyl bonds (SMUG1) nucleolus (SMUG1)
nucleus (SMUG1) DNA binding (SMUG1)
Anatomy Link Frequency
liver 6
abdomen 3
macrophage 2
brain 2
blood 2
SMUG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1519 100.00 Very High Very High Very High
positron emission tomography 1312 100.00 Very High Very High Very High
Anterior cingulate cortex 8 94.96 High High
Inflammation 216 93.72 High High
isoflurane 120 85.24 High High
anesthesia 99 84.60 Quite High
Inflammatory response 29 83.40 Quite High
Buprenorphine 5 73.56 Quite High
analgesia 5 72.00 Quite High
cytokine 24 71.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 2406 100.00 Very High Very High Very High
Breast Cancer 163 100.00 Very High Very High Very High
Dyskinesias 186 99.64 Very High Very High Very High
Epilepsy 118 99.64 Very High Very High Very High
B-cell Lymphoma 12 99.62 Very High Very High Very High
Infection 273 99.58 Very High Very High Very High
Helminth Infection 1100 99.40 Very High Very High Very High
Atherosclerosis 435 99.28 Very High Very High Very High
Fibromyalgia 105 99.24 Very High Very High Very High
Granuloma 30 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uptake of 18F-FLT was compared with uptake of 18F-FDG and Ki67 and TK1 gene expression.


Gene_expression (expression) of FDG
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.72 Pain Relevance 0.09
The assessment of residual tumor after a course of therapy (surgery, chemotherapy, or irradiation) is usually made by conventional anatomical imaging procedures, although FDG-PET is sometimes used in clinical practice during restaging.
Gene_expression (used) of FDG-PET associated with residual neoplasm and imagery
2) Confidence 0.57 Published 2010 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2892773 Disease Relevance 0.88 Pain Relevance 0.14
Even though Stumpe et al [1] found that in patients with alveolar echinococcosis baseline PET scans showed multifocally increased FDG uptake in the hepatic lesions' periphery, liver lesions were FDG negative in patients with cystic echinococcosis.


Neg (negative) Gene_expression (negative) of FDG in liver associated with echinococcosis
3) Confidence 0.50 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2257945 Disease Relevance 1.18 Pain Relevance 0.11
However, no differences with respect to biomarkers, possibly involved in tracer uptake, were seen between FDG and FLT groups.
Gene_expression (groups) of FDG
4) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.66 Pain Relevance 0.05
Compared to the control group, high levels—though not statistically significant—of glucose transporter-1, HK II, and Ki67 expression were found at the end of treatment in both FDG and FLT groups.
Gene_expression (groups) of FDG
5) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.60 Pain Relevance 0.04
For FDG as well as for FLT, a significant decline in retention (relative T/NT ratio) was observed at scan 2 (day 4).
Gene_expression (For) of FDG
6) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.40 Pain Relevance 0
One group served as control and the other two groups (FDG and FLT groups) were exposed to 22 Gy in six fractions over a 2-week treatment schedule.
Gene_expression (groups) of FDG
7) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.27 Pain Relevance 0.28
One has to bear in mind, however, that control tumors in this study were excised 16 days after start of the experiments—as a result of tumor load—compared to 36/38 days for the FDG and FLT groups.
Gene_expression (groups) of FDG associated with cancer
8) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.46 Pain Relevance 0.10
On the other hand, Humm et al. [39] reported that FDG uptake in xenografts grown in rodents was usually low, as most activity was observed in other tissues such as bladder, liver, brain, and heart.
Gene_expression (uptake) of FDG in heart
9) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.56 Pain Relevance 0.03
Next, FDG and FLT uptake in tumors during and after fractionated radiotherapy was investigated within the context of monitoring response to therapy.
Gene_expression (uptake) of FDG associated with cancer
10) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.01 Pain Relevance 0.10
FLT uptake was, however, higher then that of FDG, and both FDG and FLT uptake showed rapid response to radiotherapy.
Gene_expression (uptake) of FDG
11) Confidence 0.40 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.44 Pain Relevance 0
For the correction of blood pool activity, FDG uptake was also expressed as the ratio of aortic uptake-to-blood radioactivity.
Gene_expression (expressed) of FDG in blood
12) Confidence 0.38 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0 Pain Relevance 0.04
Recent work using micro autoradiography has demonstrated that macrophages, which are frequently found as part of granulation tissue around the tumor, often showed a higher uptake of FDG than even the tumor cells themselves [10].
Gene_expression (uptake) of FDG in granulation associated with cancer
13) Confidence 0.38 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.73 Pain Relevance 0.13
Atherosclerotic aortas showed significantly higher uptake of FDG than normal aortas (Fig. 3).
Gene_expression (uptake) of FDG in aortas associated with atherosclerosis
14) Confidence 0.38 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.80 Pain Relevance 0.04
FDG uptake by the thoracic aorta was expressed as concentration (?
Gene_expression (expressed) of FDG in thoracic aorta
15) Confidence 0.34 Published 2006 Journal BMC Nucl Med Section Abstract Doc Link PMC1479805 Disease Relevance 0.70 Pain Relevance 0.13
When FDG uptake was expressed as concentration, the correlation of aortic FDG uptake with macrophage areas as measured by histopathology was statistically significant but not high (r = 0.48, p < 0.0001) (Fig. 4A).
Gene_expression (expressed) of FDG in macrophage
16) Confidence 0.34 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.67 Pain Relevance 0.07
When FDG uptake was expressed as the ratio of aortic uptake-to-blood activity, a higher correlation (r = 0.80, p < 0.0001) between the macrophage areas and the FDG uptake ratio was observed (Figure 4B).


Gene_expression (expressed) of FDG in macrophage
17) Confidence 0.34 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.65 Pain Relevance 0.08
To reduce the influence of blood pool and surrounding structures, FDG uptake was expressed as the ratio of aortic uptake-to-blood activity, and aortic uptake was carefully measured from coregistered MR-PET images.
Gene_expression (expressed) of FDG in blood
18) Confidence 0.34 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.37 Pain Relevance 0.11
Incidental focal colorectal FDG uptakes
Gene_expression (uptakes) of FDG
19) Confidence 0.33 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2914265 Disease Relevance 1.84 Pain Relevance 0.05
Incidental focal colorectal FDG uptakes were observed in 2.1% (in 50 out of 2,338 patients not scanned for colorectal cancer or CUP).
Gene_expression (uptakes) of FDG associated with colon cancer
20) Confidence 0.33 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2914265 Disease Relevance 1.84 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox