INT162407

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, TRPV4) signal transduction (TNF) extracellular space (TNF)
cell death (TRPV4) extracellular region (TNF) intracellular (TNF)
TNF (Homo sapiens)
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 2 10.00 Low Low
TRP channel 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 4 57.32 Quite High
Cancer 4 56.96 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: TNF-alpha provides differentially enhanced synoviocyte TRPV1 and TRPV4 expression and [Ca2+]i response dependent on the TRP stimulus and time after exposure.
TNF-alpha Positive_regulation (provides) of Gene_expression (expression) of TRPV4
1) Confidence 0.47 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0.10 Pain Relevance 0
TNF-alpha increases TRPV1 (8 hr peak) and TRPV4 (12 hr peak) immunostaining, mRNA and protein expression, with a TRPV1 shift to membrane fractions.
TNF-alpha Positive_regulation (increases) of Gene_expression (expression) of TRPV4
2) Confidence 0.47 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0.11 Pain Relevance 0

General Comments

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