INT162429

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.46
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
muscles 3
astrocytes 2
motor neuron 2
muscle fibers 1
Sod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 13 99.18 Very High Very High Very High
Inflammation 34 92.80 High High
cytokine 44 84.00 Quite High
Inflammatory mediators 11 61.16 Quite High
medulla 5 51.28 Quite High
Glutamate 36 50.00 Quite Low
withdrawal 5 39.24 Quite Low
Neurotransmitter 3 34.84 Quite Low
anesthesia 3 25.00 Low Low
GABAergic 2 16.52 Low Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 38 98.92 Very High Very High Very High
Disease Progression 5 97.60 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 93.52 High High
INFLAMMATION 53 92.80 High High
Nerve Degeneration 5 91.20 High High
Weight Loss 1 80.72 Quite High
Stress 23 79.84 Quite High
Disease 56 79.40 Quite High
Neurodegenerative Disease 5 72.36 Quite High
Targeted Disruption 66 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter revealed that diminished mutant SOD1 expression in the astrocytes delayed microglial activation and slowed disease progression.
Negative_regulation (diminished) of Gene_expression (expression) of SOD1 in astrocytes associated with disease progression
1) Confidence 0.48 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19697878 Disease Relevance 0.95 Pain Relevance 0
The approach used in the latter study was to inhibit expression of mutated SOD1 protein in muscle but the results showed that the inhibition was not complete and leave open the possibility that expression in some or many muscle fibers may have been unaffected.
Negative_regulation (inhibit) of in muscle Gene_expression (expression) of SOD1 protein in muscle fibers
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.32 Pain Relevance 0.03
The results (Figure 2) confirm that expression of the mutated SOD1 protein is maintained in muscles transplanted from B6.SOD1 animals into wild-type animals.
Negative_regulation (maintained) of Gene_expression (expression) of SOD1 protein in muscles
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.12 Pain Relevance 0
The elevated expression of MnSOD, Cu/ZnSOD, reactive oxygen species (ROS), and reduction in glutathione, indicate altered redox balance upon LPS, A?
Negative_regulation (reduction) of Gene_expression (expression) of Cu/ZnSOD
4) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.37 Pain Relevance 0.26
Figure 3 indicates that the ability of direct scavenging Rot-induced ROS may be compromised in HT22 cells since the expression of the enzymes that dismutate superoxide (SOD1, SOD2) or reduce hydrogen peroxide (GPx1, catalase) was decreased following the Rot treatment.
Negative_regulation (decreased) of Gene_expression (expression) of SOD1
5) Confidence 0.18 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.13 Pain Relevance 0
In addition, expression studies of motor neuron-specific markers, vesicular acetylcholine transporter and the high affinity choline transporter, demonstrated that motor neurons in the lumbar spinal cord were partly spared from degeneration by reduced VGLUT2 expression in Sod1G93A;Vglut2flox/+ mice.
Negative_regulation (reduced) of Gene_expression (expression) of Sod1G93A in motor neuron associated with spinal cord
6) Confidence 0.03 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.47 Pain Relevance 0.23

General Comments

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