INT162432

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.34
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ar) nucleus (Ar) enzyme binding (Ar)
DNA binding (Ar) transcription factor binding (Ar) cytoplasm (Ar)
Ar (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 83.04 Quite High
anesthesia 2 71.12 Quite High
Kinase C 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 6 97.42 Very High Very High Very High
Motor Neuron Diseases 10 91.60 High High
Reprotox - General 1 70 91.44 High High
Shock 1 90.80 High High
Cancer 48 74.08 Quite High
Hyperplasia 6 73.00 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 67.76 Quite High
Disease Progression 2 67.20 Quite High
Disease 5 65.40 Quite High
Nerve Degeneration 1 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animal studies have revealed that the pathogenesis of SBMA depends on the serum testosterone level and that androgen deprivation mitigates neurodegeneration through inhibition of nuclear accumulation of the pathogenic androgen receptor (AR).
Positive_regulation (accumulation) of androgen receptor associated with muscular atrophy
1) Confidence 0.23 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19697878 Disease Relevance 1.43 Pain Relevance 0.07
Conversely, long-term removal of androgen support in LNCaP and C4-2B cells resulted in a progressive increase in SphK1 expression and activity throughout the progression to androgen-independence state, which was characterized by the acquisition of a neuroendocrine (NE)-like cell phenotype.
Positive_regulation (increase) of androgen
2) Confidence 0.04 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779655 Disease Relevance 0.38 Pain Relevance 0
IL-6 appears to be able to transactivate the androgen receptor in the absence of androgens at the N-terminal domain as well as increase the mRNA for the androgen receptor.
Positive_regulation (increase) of androgen receptor
3) Confidence 0.03 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.46 Pain Relevance 0.04

General Comments

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