INT162444

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.11
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP4A11) endoplasmic reticulum (CYP4A11)
Anatomy Link Frequency
urine 2
liver 1
hepatocytes 1
spinal cord neurons 1
CYP4A11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 98.96 Very High Very High Very High
agonist 34 97.56 Very High Very High Very High
antagonist 18 91.84 High High
IPN 1 67.88 Quite High
Inflammation 98 66.64 Quite High
Hyperalgesia 1 66.36 Quite High
Analgesic 1 55.00 Quite High
ischemia 2 43.60 Quite Low
nociceptor 1 25.00 Low Low
psoriasis 2 21.08 Low Low
Disease Link Frequency Relevance Heat
Fatty Liver 126 99.68 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 54 99.20 Very High Very High Very High
Cancer 232 98.88 Very High Very High Very High
Metabolic Syndrome 46 98.76 Very High Very High Very High
Benign Prostatic Hypertrophy 4 98.76 Very High Very High Very High
Disease Progression 6 97.56 Very High Very High Very High
Prostate Cancer 14 97.44 Very High Very High Very High
Renal Cell Carcinoma 2 94.56 High High
Stress 26 89.32 High High
Gliosarcoma 4 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modest 2-fold induction of the CYP4A11 gene by peroxisome proliferators in primary human hepatocytes compared with the 30–70 fold induction of the mouse CYP4A genes indicates a species difference between rodents and humans with respect to regulation of the CYP4A genes by peroxisome proliferators [150].
Positive_regulation (induction) of CYP4A11 in hepatocytes
1) Confidence 0.43 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.70 Pain Relevance 0.09
In humans with obesity, CYP4A11 mRNA decreased by 50% while in NAFLD patients while CYP4A11 mRNA increases 4-fold [126], suggesting a differential regulation in liver disease progression.
Positive_regulation (increases) of CYP4A11 in liver associated with fatty liver, metabolic syndrome and disease progression
2) Confidence 0.43 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.69 Pain Relevance 0.07
In primary spinal cord neurons, dipyrone selectively and dose-dependently increased 5(S)-(HETE) and 12(S)-HETE synthesis.
Positive_regulation (increased) of HETE in spinal cord neurons associated with spinal cord
3) Confidence 0.29 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19697962 Disease Relevance 0.21 Pain Relevance 0.24
In one study, 12-HETE and 20-HETE concentrations were shown to be elevated in the urine of patients with benign prostatic hypertrophy and prostate cancer patients as compared to normal subjects [95].
Positive_regulation (elevated) of 20-HETE in urine associated with benign prostatic hypertrophy and prostate cancer
4) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.25 Pain Relevance 0.11
In one study, 12-HETE and 20-HETE concentrations were shown to be elevated in the urine of patients with benign prostatic hypertrophy and prostate cancer patients as compared to normal subjects [95].
Positive_regulation (elevated) of HETE in urine associated with benign prostatic hypertrophy and prostate cancer
5) Confidence 0.00 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.26 Pain Relevance 0.11

General Comments

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