INT162454

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.28
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 4
embryos 2
ganglia 2
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 55 99.12 Very High Very High Very High
trigeminal ganglion 375 98.48 Very High Very High Very High
nociceptor 160 97.84 Very High Very High Very High
depression 2 90.28 High High
Clonidine 2 87.44 High High
Acute pain 5 77.36 Quite High
Serotonin 10 66.52 Quite High
Neuropeptide 20 45.28 Quite Low
Somatostatin 15 25.36 Quite Low
substance P 15 14.20 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 217 99.88 Very High Very High Very High
Panic Disorder 8 99.84 Very High Very High Very High
Stress 18 99.60 Very High Very High Very High
Ganglion Cysts 425 98.48 Very High Very High Very High
Disease 2 91.24 High High
Depression 2 90.28 High High
Repression 35 90.24 High High
Traumatic Stress Disorders 2 89.24 High High
Pain 15 77.36 Quite High
Nociception 15 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this aim, we have analyzed the functionality of HPA axis and the behavioral consequences of different types of stressful conditions in a mouse model of panic disorder, which overexpresses TrkC, the high affinity-receptor for NT-3 (TgNTRK3).
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of TrkC associated with panic disorder
1) Confidence 0.69 Published 2010 Journal J Psychiatr Res Section Abstract Doc Link 19698958 Disease Relevance 1.11 Pain Relevance 0.13
Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TrkC associated with panic disorder, targeted disruption and stress
2) Confidence 0.69 Published 2010 Journal J Psychiatr Res Section Title Doc Link 19698958 Disease Relevance 1.09 Pain Relevance 0.11
Discrete populations of TrkB and TrkC/Runx3 expressing neurons are maintained in wild-type ganglia at E13.5 (Figure 4I, K), and throughout development.
Positive_regulation (populations) of Gene_expression (expressing) of TrkC in ganglia
3) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.21 Pain Relevance 0.12
It is clear that Brn3a is not required for the initiation of TrkC expression because at E10.5 TrkC is expressed appropriately in Brn3a-/- embryos, and is co-expressed with TrkB in a pattern similar to the wild type (Figure 4B).
Neg (not) Positive_regulation (required) of Gene_expression (expression) of TrkC in embryos
4) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.48 Pain Relevance 0.41
No significant late appearance of TrkC-expressing neurons was observed in the Brn3a-/- TG, and the rare TrkC neurons observed at P0 are Runx3+, and have large soma characteristic of proprioceptors or mechanoreceptors (Figure 2B).
Neg (No) Positive_regulation (appearance) of Gene_expression (expressing) of TrkC in neurons associated with trigeminal ganglion
5) Confidence 0.32 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.51 Pain Relevance 0.41
In embryonic Brn3a-/- ganglia, the normal expression of Runx3 is never initiated in TrkC+ neurons, and Runx1 expression is greatly attenuated in TrkA+ nociceptors.
Positive_regulation (initiated) of Gene_expression (neurons) of TrkC in neurons associated with nociceptor
6) Confidence 0.30 Published 2010 Journal Neural Dev Section Abstract Doc Link PMC2829025 Disease Relevance 0.58 Pain Relevance 0.36
Loss of Runx3 may lead to the failure of TrkB and TrkC to segregate into distinct lineages, consistent with previous work demonstrating that Runx3 represses TrkB expression while promoting expression of TrkC [23,44].
Positive_regulation (promoting) of Gene_expression (expression) of TrkC
7) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.30 Pain Relevance 0.20

General Comments

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