INT162462

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Context Info
Confidence 0.86
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.89
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
vulva 1
apoptotic cell 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 22 99.82 Very High Very High Very High
agonist 20 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 305 100.00 Very High Very High Very High
Apoptosis 39 99.44 Very High Very High Very High
Papillomavirus Infection 674 99.20 Very High Very High Very High
Death 14 98.84 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 142 97.68 Very High Very High Very High
Infection 92 94.92 High High
Chromosome Aberrations 3 94.92 High High
Stress 8 94.48 High High
Genomic Instability 1 93.44 High High
Cervical Cancer 110 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normal cells, p53 is rapidly degraded and thus cannot be detected by immunostaining. p53 mutations produce a non-functional protein that resists degradation and can be visualized by immunostaining [11, 18].
Protein_catabolism (degraded) of p53
1) Confidence 0.86 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.73 Pain Relevance 0
Capsaicin also induced degradation of tumor suppressor p53; this effect was enhanced by the ER stressor tunicamycin.
Protein_catabolism (degradation) of p53 associated with qutenza and cancer
2) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.17 Pain Relevance 0.68
The proteasome inhibitor MG132 completely blocked capsaicin-induced p53 degradation and enhanced apoptotic cell death.
Protein_catabolism (degradation) of p53 in apoptotic cell associated with qutenza, apoptosis and death
3) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.24 Pain Relevance 0.74
E6 inhibits p53 function by binding with E6-AP ubiquitin ligase, and leads to p14ARF upregulation via p53 degradation by negative feedback mechanism [22, 23].
Protein_catabolism (degradation) of p53
4) Confidence 0.50 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.15 Pain Relevance 0
Frequent detection of over-expression of p14ARF and p16INK4A in VIN suggests that degradation and inactivation of p53 and Rb are early events in carcinogenesis of HPV-related SCC of the vulva.
Protein_catabolism (degradation) of p53 in vulva associated with papillomavirus infection, basal and squamous cell skin cancer and cancer
5) Confidence 0.33 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.43 Pain Relevance 0
ligase that targets p53 to proteosomal degradation [11].
Protein_catabolism (degradation) of p53
6) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.98 Pain Relevance 0
The first transforming activity identified for the high-risk HPV E6 proteins was the ability to mediate p53 degradation through the ubiquitin proteolysis pathway [48], a property not possessed by the low-risk HPV E6 proteins.
Protein_catabolism (degradation) of p53 associated with papillomavirus infection
7) Confidence 0.09 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 0.86 Pain Relevance 0
Mkrn1 is also involved in the control of cell cycle arrest and apoptosis through ubiquitination and proteasome-dependent degradation of proteins p53 and p21 [6].
Protein_catabolism (degradation) of p53 associated with apoptosis
8) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3022923 Disease Relevance 0.32 Pain Relevance 0

General Comments

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