INT162467

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.11
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ERN1) endoplasmic reticulum (ERN1)
Anatomy Link Frequency
band 1
thalamus 1
lung 1
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.10 Very High Very High Very High
tolerance 4 97.92 Very High Very High Very High
Thalamus 4 97.12 Very High Very High Very High
addiction 3 82.76 Quite High
aspirin 16 73.28 Quite High
cINOD 22 72.84 Quite High
Autonomic response 14 48.56 Quite Low
antagonist 4 47.08 Quite Low
deep brain stimulation 19 43.92 Quite Low
Anterior cingulate cortex 3 39.92 Quite Low
Disease Link Frequency Relevance Heat
Stress 143 99.70 Very High Very High Very High
Death 14 97.76 Very High Very High Very High
Apoptosis 25 97.32 Very High Very High Very High
Nicotine Addiction 60 94.00 High High
Parkinson's Disease 1 90.64 High High
Cancer 81 90.12 High High
Genomic Instability 2 87.20 High High
Increased Venous Pressure Under Development 212 84.44 Quite High
Ataxia 24 83.52 Quite High
Sideroblastic Anemia 15 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Gene_expression (levels) of IRE1 associated with stress and qutenza
1) Confidence 0.56 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.22 Pain Relevance 0.74
It is possible that one or more components of CS can attack the structure of the IRE1 transmembrane protein thereby disabling its ribonuclease function and subsequent splicing of the XBP1 mRNA to its transcriptionally active isoform.
Gene_expression (function) of IRE1
2) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.71 Pain Relevance 0
Effect of CS exposure on the IRE1 branch of UPR in normal human lung cells
Gene_expression (exposure) of IRE1 in lung
3) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.48 Pain Relevance 0
ms and coherence analysis (Figure 2C) showed a higher correlation for error than correct trials in the frequency band of the ERN between the Ncl accumbens and the scalp surface.
Gene_expression (accumbens) of ERN in band
4) Confidence 0.18 Published 2008 Journal Frontiers in Neuroscience Section Body Doc Link PMC2570064 Disease Relevance 0.20 Pain Relevance 0
Early experience with laropiprant and ERN
Gene_expression (experience) of ERN
5) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.26 Pain Relevance 0
The addition of laropiprant did not interfere with the efficacy of ERN and similar effects on lipid profiles were observed in the LERN and ERN groups.
Gene_expression (groups) of ERN
6) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.26 Pain Relevance 0
Also, in this trial, symptoms in the laropiprant group decrease after week 5 but persisted in the ERN group, which were consistent with findings from earlier phase III trials.
Gene_expression (group) of ERN
7) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.32 Pain Relevance 0.21
Also, the persistence of symptoms over a 24 weeks period in the ERN group suggested that most of the patients do not develop tolerance and explains the high discontinuation rates in the first year in clinical practice.38
Gene_expression (group) of ERN associated with tolerance
8) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857616 Disease Relevance 0.43 Pain Relevance 0.23
In a group of patients with focal lesions of the thalamus we found significantly impaired error awareness in a flanker task (signaling rate, patients, 39.1 vs. controls 85.1%) accompanied by amplitude reduction of the ERN and Pe (Seifert et al. 2010).
Gene_expression (reduction) of ERN in thalamus associated with thalamus
9) Confidence 0.12 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.24 Pain Relevance 0.09
IRE (32); these two transcripts are simultaneously expressed only in erythroid cells, where activation of IRPs would be expected to cause unique effects.
Gene_expression (expressed) of IRE
10) Confidence 0.03 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.99 Pain Relevance 0

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