INT162471

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.02
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (ERN1) endoplasmic reticulum (ERN1)
Anatomy Link Frequency
A549 1
ERN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 11 99.32 Very High Very High Very High
imagery 4 79.44 Quite High
Pain 9 71.68 Quite High
Anterior cingulate cortex 4 69.36 Quite High
Autonomic response 2 60.52 Quite High
Inflammation 20 56.00 Quite High
chemokine 1 47.68 Quite Low
cytokine 15 38.40 Quite Low
Inflammatory mediators 1 37.04 Quite Low
Nicotine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 153 99.92 Very High Very High Very High
Nicotine Addiction 60 98.20 Very High Very High Very High
Death 10 98.20 Very High Very High Very High
Apoptosis 30 97.76 Very High Very High Very High
Protein Deficiency 2 92.76 High High
Anxiety Disorder 2 92.36 High High
Cancer 81 90.56 High High
Iron Overload 48 84.92 Quite High
Anaemia 36 76.48 Quite High
Pain 7 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of IRE1 associated with stress and qutenza
1) Confidence 0.34 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
To determine if the lack of splicing is due to a minimal impact of CS on IRE1 activation or active interference with the splicing mechanism, we performed a dual-treatment experiment in which A549 cells were first treated with CS and subsequently with thapsigargin or tunicamycin.
Positive_regulation (activation) of IRE1 in A549
2) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.06 Pain Relevance 0
Clearly, further research to determine if IRE1 activation and/or XBP1 splicing is corrupted in actual smokers would be valuable.
Positive_regulation (activation) of IRE1 associated with nicotine addiction
3) Confidence 0.27 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.83 Pain Relevance 0
Moreover, recent studies demonstrated an effect of short-term emotions on the ERN such that the presentation of unpleasant IAPS pictures during a simple choice reaction time task led to an increased ERN [32], but see [33].
Positive_regulation (increased) of ERN
4) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2918625 Disease Relevance 0.24 Pain Relevance 0.28
IRE-containing transcripts (mostly iron-utilizing genes) but promotes the stability and translation of 3?
Positive_regulation (promotes) of IRE
5) Confidence 0.03 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.47 Pain Relevance 0
S cluster, IRP1 is activated to become an IRE-binding protein, which increases the rate of cellular iron uptake and decreases the rate of iron sequestration by stabilizing TfR1 mRNA and repressing ferritin synthesis.
Positive_regulation (activated) of IRE
6) Confidence 0.03 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.08 Pain Relevance 0
The ERN is thus elicited in cases in which the performer registers an action error.
Positive_regulation (elicited) of ERN
7) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2918625 Disease Relevance 0.05 Pain Relevance 0.03
Activation of the UPR gene expression program is initiated by at least three ER transmembrane protein sensors, including ATF-6, IRE-1, and PERK.
Positive_regulation (Activation) of IRE-1
8) Confidence 0.01 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.06 Pain Relevance 0.03

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