INT162499

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.19
Pain Relevance 0.49

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cytoplasm (AHR, NEUROD1) nucleus (AHR, NEUROD1) transcription factor binding (AHR, NEUROD1)
nucleoplasm (NEUROD1) immune system process (AHR) cell morphogenesis (AHR)
AHR (Homo sapiens)
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 4 86.64 High High
Leflunomide 4 60.48 Quite High
lidocaine 4 58.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors.
AhR Binding (ligand) of basic helix-loop-helix protein
1) Confidence 0.25 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754423 Disease Relevance 0 Pain Relevance 0.15
Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors.
hydrocarbon receptor Binding (ligand) of basic helix-loop-helix protein
2) Confidence 0.22 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754423 Disease Relevance 0 Pain Relevance 0.16
Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors.
AhR Binding (ligand) of basic helix-loop-helix protein
3) Confidence 0.18 Published 2009 Journal Curr. Drug Metab. Section Abstract Doc Link 19702529 Disease Relevance 0.09 Pain Relevance 0.09
Similar to CYP1A1 and 1B1, CYP1A2 is primarily regulated by the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor and a basic helix-loop-helix protein belonging to the Per-Arnt-Sim family of transcription factors.
hydrocarbon receptor Binding (ligand) of basic helix-loop-helix protein
4) Confidence 0.16 Published 2009 Journal Curr. Drug Metab. Section Abstract Doc Link 19702529 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

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