INT162513

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 1.79
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 4
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 63 100.00 Very High Very High Very High
cINOD 11 99.64 Very High Very High Very High
Inflammation 1 51.44 Quite High
aspirin 3 7.92 Low Low
Potency 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 49 100.00 Very High Very High Very High
INFLAMMATION 4 96.84 Very High Very High Very High
Disease 13 90.56 High High
Neuroblastoma 8 82.12 Quite High
Amyloid Plaque 35 71.56 Quite High
Infection 1 70.96 Quite High
Hypopigmentation 1 62.64 Quite High
Stress 17 49.56 Quite Low
Drug Induced Neurotoxicity 3 40.64 Quite Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apparently, NSAID has differential affects on the selective cleavage of APP-CTFs by the ?
Regulation (affects) of Protein_catabolism (cleavage) of APP in cleavage associated with cinod
1) Confidence 0.51 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.10
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Regulation (modulation) of Protein_catabolism (degradation) of amyloid-beta associated with alzheimer's dementia and abeta
2) Confidence 0.39 Published 2009 Journal J. Neurochem. Section Title Doc Link 19702658 Disease Relevance 0.53 Pain Relevance 0.65
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels.
Regulation (modulation) of Protein_catabolism (degradation) of Abeta associated with alzheimer's dementia and abeta
3) Confidence 0.27 Published 2009 Journal J. Neurochem. Section Title Doc Link 19702658 Disease Relevance 0.54 Pain Relevance 0.69
These results, suggesting that drugs modulate the ability of cell-derived factors to degrade Abeta, was interrogated by adding protease inhibitors and performing molecular weight cut-off fractionation.
Regulation (modulate) of Protein_catabolism (degrade) of Abeta associated with abeta
4) Confidence 0.24 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19702658 Disease Relevance 0.40 Pain Relevance 0.89
-secretase-mediated APP cleavage was not affected by a low concentration of H2O2 (from 1 to 100 ?
Neg (not) Regulation (affected) of Protein_catabolism (cleavage) of APP in cleavage
5) Confidence 0.23 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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