INT162518

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 1.96
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rela) nucleus (Rela) DNA binding (Rela)
protein complex (Rela) transcription factor binding (Rela) cytoplasm (Rela)
Anatomy Link Frequency
nucleus 4
microglia 2
Rela (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 234 99.82 Very High Very High Very High
Substantia nigra 74 96.64 Very High Very High Very High
Paracetamol 8 80.92 Quite High
cytokine 217 77.72 Quite High
Inflammatory mediators 5 77.04 Quite High
Inflammation 77 67.56 Quite High
dopaminergic neurodegeneration 10 50.00 Quite Low
opiate 54 9.24 Low Low
chemokine 33 5.00 Very Low Very Low Very Low
Inflammatory response 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 183 98.92 Very High Very High Very High
Synovial Sarcoma 35 88.84 High High
INFLAMMATION 107 77.04 Quite High
Hepatocellular Cancer 2 73.68 Quite High
Adhesions 4 70.72 Quite High
Apoptosis 187 51.76 Quite High
Cancer 140 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 96 50.00 Quite Low
Necrosis 15 50.00 Quite Low
Cv General 2 Under Development 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B and reduced Tat±morphine-induced increases in p65 nuclear translocation.
Positive_regulation (increases) of Localization (translocation) of p65 associated with morphine
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.36
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Positive_regulation (increased) of Localization (translocation) of RelA associated with morphine
2) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.79
Tat±morphine markedly increased the translocation of the p65 (RelA) subunit of NF-?
Positive_regulation (increased) of Localization (translocation) of p65 associated with morphine
3) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.79
-induced p65 nuclear translocation and p65 phosphorylation in pancreatic cancer cells
Positive_regulation (induced) of Localization (translocation) of p65 associated with pancreatic cancer
4) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.41 Pain Relevance 0
B p65 was decreased, rather than increased, in the Fc?
Positive_regulation (increased) of Localization (decreased) of p65
5) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.22 Pain Relevance 0.16
In our model, we observed increased mRNA for both p65 and p50, but only the p65 protein exhibited prominent accumulation in microglia.
Positive_regulation (increased) of Localization (mRNA) of p65 in microglia
6) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0 Pain Relevance 0
induced p65 nuclear translocation and p65 phosphorylation (Fig. 4B, right), suggesting that MA suppresses TNF?
Positive_regulation (induced) of Localization (translocation) of p65
7) Confidence 0.22 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.42 Pain Relevance 0
induced p65 nuclear translocation and p65 phosphorylation (Fig. 4B, right), suggesting that MA suppresses TNF?
Positive_regulation (induced) of Localization (translocation) of p65
8) Confidence 0.21 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.47 Pain Relevance 0
induces RelA nuclear translocation, and this effect is largely abrogated by
Positive_regulation (induces) of Localization (translocation) of RelA
9) Confidence 0.16 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 0.24 Pain Relevance 0
B-p65 cellular localisation shows an increase in NF-?
Positive_regulation (increase) of Localization (localisation) of p65
10) Confidence 0.11 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.07 Pain Relevance 0.16
B-p65 cellular abundance (Fig. 3A, second panel) and a clear increase in Nrf2 (Fig. 3B, second panel) accumulation in the nucleus after 1 h of DNCB treatment.
Positive_regulation (increase) of Localization (abundance) of p65 in nucleus
11) Confidence 0.10 Published 2010 Journal Biochemical Pharmacology Section Body Doc Link PMC2884179 Disease Relevance 0.07 Pain Relevance 0.15
METHODS: C. racemosa rhizome and phosphate-buffered saline extracts were analysed for phenolcarboxylic acids and triterpene glycosides using an HPLC photodiode array/evaporative light-scattering detector system. iNOS was characterised by measurement of iNOS protein (immunoblotting), iNOS mRNA (semiquantitative competitive RT-PCR), nitric oxide production (nitrite levels) and nuclear translocation of nuclear factor-kappaB (p65 subunit) protein.
Positive_regulation (measurement) of Localization (translocation) of p65 subunit
12) Confidence 0.07 Published 2009 Journal J. Pharm. Pharmacol. Section Body Doc Link 19703353 Disease Relevance 0 Pain Relevance 0
Using immunofluorescence, we determined whether exposure of BMSC to neurotrophins induced nuclear translocation of the p65 subunit of NF-?
Spec (whether) Positive_regulation (induced) of Localization (translocation) of p65
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
, which was used as a positive control, induced rapid translocation of the p65 subunit from the cytoplasm to the nucleus in the BMSC (Figure 5A).
Positive_regulation (induced) of Localization (translocation) of p65 in nucleus
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0

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