INT16253

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 8
Speculated 8
Reported most in Abstract
Documents 196
Total Number 207
Disease Relevance 92.67
Pain Relevance 113.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 44
neurons 41
DRG 19
hippocampus 17
microglia 16
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 4146 100.00 Very High Very High Very High
Spinal cord 1867 100.00 Very High Very High Very High
Pain 797 100.00 Very High Very High Very High
depression 680 100.00 Very High Very High Very High
antidepressant 656 100.00 Very High Very High Very High
long-term potentiation 516 100.00 Very High Very High Very High
Nerve growth factor 313 100.00 Very High Very High Very High
Inflammation 248 100.00 Very High Very High Very High
Fibrositis 12 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1202 100.00 Very High Very High Very High
Nociception 260 100.00 Very High Very High Very High
Aids-related Complex 167 100.00 Very High Very High Very High
Urological Neuroanatomy 50 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 36 100.00 Very High Very High Very High
Sleep Disorders 12 100.00 Very High Very High Very High
Stress 493 99.98 Very High Very High Very High
INFLAMMATION 325 99.98 Very High Very High Very High
Cv Unclassified Under Development 321 99.98 Very High Very High Very High
Neuropathic Pain 584 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant upregulation of BDNF gene expression was found only in injured DRG of F344 rats, thus correlating with higher resistance to neuropathic pain.
Positive_regulation (upregulation) of Gene_expression (expression) of BDNF in DRG associated with neuropathic pain
1) Confidence 0.70 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.18 Pain Relevance 0.93
These data show that chronic treatment with fluoxetine increases BDNF gene expression not only in limbic areas but also in dopaminergic regions, suggesting that such an effect may contribute to improve the function of the dopaminergic system in depressed subjects.
Positive_regulation (increases) of Gene_expression (expression) of BDNF gene associated with fluoxetine
2) Confidence 0.70 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035958 Disease Relevance 0.07 Pain Relevance 0.69
The pain-evoked up-regulation of spinal BDNF gene expression was significantly potentiated by concomitant estrogen treatment.
Positive_regulation (up-regulation) of Gene_expression (expression) of BDNF gene in spinal associated with pain
3) Confidence 0.70 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.03 Pain Relevance 0.77
After transfection of the rat BDNF gene into RN46A cells, an autocrine BDNF-secreting cell line, 46A-B14, was isolated and transplanted into the rat CNS.
Positive_regulation (transfection) of Gene_expression (transfection) of BDNF gene
4) Confidence 0.70 Published 1997 Journal Pain Section Abstract Doc Link 9272788 Disease Relevance 0.47 Pain Relevance 0.48
Repeated (2-3 weeks) administration of antidepressant drugs increases BDNF gene expression.
Positive_regulation (increases) of Gene_expression (expression) of BDNF associated with antidepressant
5) Confidence 0.70 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.37
As compared with the dynamic changes of 50% PWT in the timeline after nerve injury, the maximal enhancement of BDNF expression closely paralleled the maximal decline in the slope of 50% PWT, while the peak of NMDA-2B receptors expression corresponded with the plateau of the decreased 50% PWT.
Positive_regulation (enhancement) of Gene_expression (expression) of BDNF in nerve associated with nervous system injury
6) Confidence 0.70 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.53 Pain Relevance 0.62
The maximal enhancement of BDNF expression occurred in early stage (24-48 h) after nerve injury, while the peak of NMDA-2B receptors expression appeared in late stage (3-14 days) post-nerve ligation.
Positive_regulation (enhancement) of Gene_expression (expression) of BDNF in nerve associated with nervous system injury
7) Confidence 0.70 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.31 Pain Relevance 0.46
These results suggest that increased BDNF expression in intact primary sensory neurons and spinal cord may be an important factor in the induction of neuropathic pain without axotomy of sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of BDNF in sensory neurons associated with neuropathic pain and spinal cord
8) Confidence 0.70 Published 2006 Journal Neurotox Res Section Abstract Doc Link 16782586 Disease Relevance 0.47 Pain Relevance 0.54
L5SSNL increased significantly (P<0.05) the expression of total BDNF mRNA and exon I, IIA, IIB, IIC, III, IV, VI, and IXA transcripts in ipsilateral L4 DRG.
Positive_regulation (increased) of Gene_expression (expression) of BDNF mRNA in DRG associated with dorsal root ganglion
9) Confidence 0.70 Published 2008 Journal Brain Res. Section Abstract Doc Link 18353280 Disease Relevance 0.57 Pain Relevance 0.54
These findings suggest that peripheral inflammation induces an increased expression of BDNF mRNA which is mediated by NGF in DRG.
Positive_regulation (increased) of Gene_expression (expression) of BDNF mRNA in DRG associated with dorsal root ganglion, nerve growth factor and inflammation
10) Confidence 0.70 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.96 Pain Relevance 0.71
These findings suggest that peripheral inflammation induces an increased expression of BDNF mRNA which is mediated by NGF in DRG.
Positive_regulation (induces) of Gene_expression (expression) of BDNF mRNA in DRG associated with dorsal root ganglion, nerve growth factor and inflammation
11) Confidence 0.70 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.97 Pain Relevance 0.72
This suggests that surgical incision induce the shift of BDNF expression from small-sized neurons to large-sized neurons in DRG.
Positive_regulation (induce) of Gene_expression (expression) of BDNF in neurons associated with bdmf
12) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.61
Increased BDNF expression in the DRG after hind-paw incision
Positive_regulation (Increased) of Gene_expression (expression) of BDNF in paw associated with bdmf
13) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0 Pain Relevance 0.77
In this regard, considerable evidence shows that neuronal depolarization induced by KCL or electrical stimulation of C fibers can induce the sustained increase of BDNF expression in cerebellar granule or sensory neurons [26-28].
Positive_regulation (induce) of Gene_expression (expression) of BDNF in neuronal associated with bdmf
14) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.27 Pain Relevance 1.10
The results revealed an increase in the expression of BDNF and TrkB in the amygdala after NMS.
Positive_regulation (increase) of Gene_expression (expression) of BDNF in amygdala associated with neuroleptic malignant syndrome and amygdala
15) Confidence 0.69 Published 2009 Journal Neurosignals Section Abstract Doc Link 19546592 Disease Relevance 1.07 Pain Relevance 0.66
Results showed that chronic administration of morphine significantly increased BDNF and NT-3 gene expression in PGi.
Positive_regulation (increased) of Gene_expression (expression) of BDNF associated with bdmf and morphine
16) Confidence 0.68 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.15 Pain Relevance 1.66
tetanization really increased BDNF expression but solely in some restricted
Positive_regulation (increased) of Gene_expression (expression) of BDNF
17) Confidence 0.68 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0.19
actually lead to increased BDNF expression.
Positive_regulation (increased) of Gene_expression (expression) of BDNF
18) Confidence 0.68 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.07 Pain Relevance 0.22
Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via alpha1- and beta1/beta2-adrenergic receptors.
Positive_regulation (stimulation) of Gene_expression (synthesis) of BDNF in astrocytes
19) Confidence 0.67 Published 2008 Journal Neurochem. Int. Section Title Doc Link 17681645 Disease Relevance 0 Pain Relevance 0.34
Since astrocytes express various subtypes of alpha- and beta-adrenergic receptors that have the potential to be activated by synaptically released NA, we focused our present study on the mediatory role of adrenergic receptors in the noradrenergic up-regulation of BDNF synthesis in cultured neonatal rat cortical astrocytes.
Positive_regulation (up-regulation) of Gene_expression (synthesis) of BDNF in astrocytes associated with noradrenaline
20) Confidence 0.67 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17681645 Disease Relevance 0 Pain Relevance 0.40

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