INT162531

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.80
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
tunica media 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 12 93.04 High High
Inflammation 94 91.44 High High
cva 4 60.52 Quite High
Angina 1 56.32 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
halothane 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Valve Stenosis 7 99.78 Very High Very High Very High
Syndrome 1 98.80 Very High Very High Very High
Togavirus Infection 2 97.64 Very High Very High Very High
Pathologic Constriction 20 95.56 Very High Very High Very High
Spinal Cord Injury 124 93.60 High High
Disease 13 92.56 High High
Injury 22 92.28 High High
Vasculitis 1 91.64 High High
INFLAMMATION 104 91.44 High High
Aortic Coarctation 1 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the organic solvent mixture described above, almost all of the radioactivity was not collected from the thoracic aorta, and approximately 90% was recovered by treatment with elastase, which suggests that some metabolites covalently bind to the elastin fiber localized in the tunica media.
elastin Binding (bind) of in tunica media
1) Confidence 0.43 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 19704029 Disease Relevance 0.11 Pain Relevance 0.06
The protein encoded by the LOX gene is an extracellular copper-containing enzyme that initiates the cross-linking of collagens and elastin.
elastin Binding (linking) of
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.80 Pain Relevance 0.15
The protein encoded by the LOX gene is an extracellular copper-containing enzyme that initiates the cross-linking of collagens and elastin.
elastin Binding (cross) of
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.81 Pain Relevance 0.15
PPS due to an elastin arteriopathy can be associated with a variety of congenital syndromes such as congenital rubella, Williams, Noonan, Alagille, Silver and Ehlers-Danlos [7].
elastin Binding (associated) of associated with syndrome, togavirus infection and pulmonary valve stenosis
4) Confidence 0.03 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 2.07 Pain Relevance 0.06

General Comments

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