INT162538

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.35
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gucy2c)
Anatomy Link Frequency
visceral 2
intestine 1
Gucy2c (Mus musculus)
Pain Link Frequency Relevance Heat
Visceral pain 4 98.56 Very High Very High Very High
nud 4 98.36 Very High Very High Very High
Inflammation 18 98.28 Very High Very High Very High
Bioavailability 1 97.00 Very High Very High Very High
abdominal pain 2 94.96 High High
spastic colon 3 88.84 High High
allodynia 4 83.96 Quite High
Hyperalgesia 2 83.40 Quite High
Antinociceptive 2 75.00 Quite High
agonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 98.56 Very High Very High Very High
Dyspepsia 4 98.36 Very High Very High Very High
INFLAMMATION 10 98.28 Very High Very High Very High
Nociception 4 96.68 Very High Very High Very High
Stress 12 91.92 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

13 91.32 High High
Constipation 6 90.16 High High
Functional Bowel Disorder 3 88.84 High High
Hypersensitivity 2 87.68 High High
Neuropathic Pain 2 83.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS & INFERENCES These findings indicate that linaclotide has potent anti-nociceptive effects in several mechanistically different rodent models of visceral hypersensitivity and that these pharmacological properties of linaclotide are exerted through the activation of the GC-C receptor.
Positive_regulation (activation) of GC-C in visceral associated with nociception and nud
1) Confidence 0.67 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19706070 Disease Relevance 1.03 Pain Relevance 0.59
We determined the stability of linaclotide in the intestine, measured the oral bioavailability, and investigated whether the pharmacodynamic effects elicited in rodent models of gastrointestinal function are mechanistically linked to the activation of intestinal guanylate cyclase C (GC-C).
Spec (whether) Positive_regulation (activation) of GC-C in intestine associated with bioavailability
2) Confidence 0.67 Published 2010 Journal Life Sci. Section Abstract Doc Link 20307554 Disease Relevance 0.27 Pain Relevance 0.17
Therefore, we investigated the anti-nociceptive properties of linaclotide in rodent models of inflammatory and non-inflammatory visceral pain and determined whether these pharmacological effects are linked to the activation of guanylate cyclase C (GC-C).
Spec (whether) Positive_regulation (activation) of GC-C in visceral associated with nociception, visceral pain and inflammation
3) Confidence 0.45 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19706070 Disease Relevance 1.18 Pain Relevance 0.60

General Comments

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