INT16254

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1986
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 144
Total Number 148
Disease Relevance 80.61
Pain Relevance 82.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 65
neurons 20
bladder 15
dorsal root ganglion 11
brain 10
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2683 100.00 Very High Very High Very High
Inflammation 499 100.00 Very High Very High Very High
Pain 395 100.00 Very High Very High Very High
cytokine 126 100.00 Very High Very High Very High
Hyperalgesia 113 100.00 Very High Very High Very High
dorsal root ganglion 102 100.00 Very High Very High Very High
nociceptor 97 100.00 Very High Very High Very High
Thermal hyperalgesia 39 100.00 Very High Very High Very High
bDMF 34 100.00 Very High Very High Very High
Kinase C 28 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 503 100.00 Very High Very High Very High
Ganglion Cysts 255 100.00 Very High Very High Very High
Cancer 191 100.00 Very High Very High Very High
Hyperalgesia 164 100.00 Very High Very High Very High
Nociception 160 100.00 Very High Very High Very High
Cystitis 51 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Burns 10 100.00 Very High Very High Very High
Shock 9 100.00 Very High Very High Very High
Asthma 8 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A substantial increase in NGF protein expression occurred in skin 4-h, 1-day and 2-days and 5-days after incision comparing contralateral uninjured skin.
Positive_regulation (increase) of Gene_expression (expression) of NGF protein in skin associated with nerve growth factor
1) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16061324 Disease Relevance 0.42 Pain Relevance 0.74
These data demonstrate that a transient increase in NGF expression without associated inflammation sensitizes visceral reflex pathways, leading to bladder overactivity.
Positive_regulation (increase) of Gene_expression (expression) of NGF in bladder associated with inflammation and nerve growth factor
2) Confidence 0.70 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.47 Pain Relevance 0.86
Increased nerve growth factor expression triggers bladder overactivity.
Positive_regulation (Increased) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor
3) Confidence 0.70 Published 2004 Journal J Pain Section Title Doc Link 15106127 Disease Relevance 0.40 Pain Relevance 0.71
Prior studies have demonstrated an association between visceral inflammation, an increase in nerve growth factor (NGF) expression, and development of hyperalgesia.
Positive_regulation (increase) of Gene_expression (expression) of nerve growth factor in visceral associated with hyperalgesia, nerve growth factor and inflammation
4) Confidence 0.70 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.29 Pain Relevance 0.48
Cerebellar and striatal, but not hippocampal, astrocytes prepared from naltrexone-treated animals produced higher levels of NGF than those from controls.
Positive_regulation (levels) of Gene_expression (produced) of NGF in astrocytes associated with nerve growth factor
5) Confidence 0.70 Published 1993 Journal J. Mol. Neurosci. Section Abstract Doc Link 7686388 Disease Relevance 0 Pain Relevance 0.62
The candidate antisense oligos were evaluated for their ability to reduce NGF expression in vitro by cotransfecting HEK293 cells with NGF cDNA.
Positive_regulation (cotransfecting) of Gene_expression (cotransfecting) of NGF
6) Confidence 0.70 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.41 Pain Relevance 0.18
Overexpression of NGF has been linked to the pathogenesis of interstitial cystitis (IC).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NGF associated with interstitial cystitis
7) Confidence 0.70 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.30 Pain Relevance 0.18
Overexpression of NGF is known to mediate inflammation of bladder in this model.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NGF in bladder associated with inflammation
8) Confidence 0.70 Published 2006 Journal Mol. Pharm. Section Abstract Doc Link 16889433 Disease Relevance 0.43 Pain Relevance 0.17
Excitation of primary afferent neurons stimulates the expression of cytokines and nerve growth factor (NGF) in innervated tissues.
Positive_regulation (stimulates) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor and cytokine
9) Confidence 0.70 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0.27 Pain Relevance 0.77
Somato-visceral cross sensitization between somatic (pudendal) and visceral (bladder) sensory pathways that increases NGF expression and alpha(1)-adrenoceptor-mediated contractility in the bladder may be involved in this pathophysiological mechanism.
Positive_regulation (increases) of Gene_expression (expression) of NGF in bladder associated with nerve growth factor
10) Confidence 0.70 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18337317 Disease Relevance 0.78 Pain Relevance 0.37
Immunostaining showed increased NGF expression in the urothelium, most marked in patients with idiopathic sensory urgency.
Positive_regulation (increased) of Gene_expression (expression) of NGF
11) Confidence 0.70 Published 1997 Journal Br J Urol Section Body Doc Link 9126085 Disease Relevance 0.14 Pain Relevance 0
Previously, we observed that, after dorsal rhizotomy, overexpression of NGF leads to robust regeneration and sprouting of calcitonin gene-related peptide (CGRP)-positive nociceptive axons throughout dorsal horn and ventral horns.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF in dorsal horn associated with nociception, dorsal rhizotomy, dorsal horn and calcitonin gene-related peptide
12) Confidence 0.69 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17537979 Disease Relevance 0.41 Pain Relevance 0.43
Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve.
Positive_regulation (overexpression) of Gene_expression (overexpression) of nerve growth factor in peripheral nerve associated with nerve growth factor and nociceptor
13) Confidence 0.69 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18973572 Disease Relevance 0.20 Pain Relevance 0.29
In the experiments described here, we examined the effect of LV vector-mediated overexpression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) on regeneration of the rat peripheral nerve in a transection/repair model in vivo.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF in peripheral nerve associated with nerve growth factor
14) Confidence 0.69 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.14 Pain Relevance 0.21
For sensory neurons, increased levels of NGF and GDNF do not affect the number of regenerated neurons 1 cm distal to a lesion at 4 weeks post-lesion but do cause changes in the expression of markers for different populations of nociceptive neurons.
Positive_regulation (increased) of Gene_expression (levels) of NGF in sensory neurons associated with nociception and nerve growth factor
15) Confidence 0.69 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.24 Pain Relevance 0.25
Dysreflexic hypertension was significantly higher with NGF overexpression in lumbosacral segments compared with GFP, whereas similar overexpression of Sema3a significantly reduced noxious CRD-evoked hypertension.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF associated with nerve growth factor and hypertension
16) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540569 Disease Relevance 0.81 Pain Relevance 0.53
CFA injection resulted in mechanical and thermal hyperalgesia and an elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) in the ipsilateral hindpaw.
Positive_regulation (resulted) of Gene_expression (levels) of NGF in nerve associated with nerve growth factor and thermal hyperalgesia
17) Confidence 0.69 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887968 Disease Relevance 0.75 Pain Relevance 0.80
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Positive_regulation (upregulated) of Gene_expression (synthesis) of NGF in nerve associated with nervous system injury and nerve growth factor
18) Confidence 0.69 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.61 Pain Relevance 0.39
CONCLUSION/INTERPRETATION: These findings show that in animal models of diabetes it is possible to prevent depletions of nerve growth factor and the products of its neuronal target genes by oral treatment of a highly potent inducer of NGF gene expression.
Positive_regulation (inducer) of Gene_expression (expression) of NGF gene in nerve
19) Confidence 0.69 Published 1999 Journal Diabetologia Section Body Doc Link 10550414 Disease Relevance 0 Pain Relevance 0
We, therefore, examined a novel agent (CB1093; 1(S), 3(R)-Dihydroxy-20(R)-(1-ethoxy-5-ethyl-5-hydroxy-2-heptyn-1-yl)-9, 10-seco-pregna-5(Z),7(E),10(19)-triene), which induces expression of endogenous nerve growth factor.
Positive_regulation (induces) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor
20) Confidence 0.69 Published 1999 Journal Diabetologia Section Abstract Doc Link 10550414 Disease Relevance 0.16 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox