INT16255

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 12.92
Pain Relevance 11.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
spinal cord 3
nerve 3
hippocampus 2
neurons 1
limb muscles 1
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 66 100.00 Very High Very High Very High
neurotrophin 3 36 100.00 Very High Very High Very High
Hyperalgesia 21 99.92 Very High Very High Very High
bDMF 4 99.84 Very High Very High Very High
antagonist 9 99.76 Very High Very High Very High
Sciatic nerve 11 99.68 Very High Very High Very High
Morphine 11 99.50 Very High Very High Very High
Spinal cord 158 99.40 Very High Very High Very High
Hippocampus 86 99.40 Very High Very High Very High
Thermal hyperalgesia 12 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 34 99.92 Very High Very High Very High
Stress 217 99.82 Very High Very High Very High
Neuropathy 14 99.76 Very High Very High Very High
Targeted Disruption 11 99.28 Very High Very High Very High
Neurodegenerative Disease 20 99.18 Very High Very High Very High
Diabetes Mellitus 155 98.88 Very High Very High Very High
Convulsion 14 98.74 Very High Very High Very High
Diabetic Neuropathy 62 97.84 Very High Very High Very High
Injury 90 96.72 Very High Very High Very High
Frailty 6 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NT-3 levels in the plantar skin were much higher than NGF levels (1.24 and 0.14 ng/g tissue, respectively) before CFA injection, but decreased significantly 6 h to 48 h after the injection while NGF was markedly induced at 6 h but decreased thereafter.
Negative_regulation (decreased) of NT-3 in skin associated with nerve growth factor
1) Confidence 0.51 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10713396 Disease Relevance 0.79 Pain Relevance 0.87
The oligonucleotides used in this study were phosphorothioate modified and control experiments, using an ELISA, confirm that intrathecal administration of the antisense induces a significant decrease in NT-3 levels in the spinal cord.
Negative_regulation (decrease) of NT-3 in spinal cord associated with spinal cord and intrathecal
2) Confidence 0.51 Published 2000 Journal Brain Res. Section Abstract Doc Link 11121532 Disease Relevance 0.71 Pain Relevance 0.92
Recurrent seizures are found to increase levels of mRNAs for NGF and BDNF and to decrease levels of mRNA for NT3 within select hippocampal neurons.
Negative_regulation (decrease) of NT3 in neurons associated with convulsion, neurotrophin 3, nerve growth factor and bdmf
3) Confidence 0.42 Published 1991 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1815605 Disease Relevance 0.67 Pain Relevance 0.82
In the present study, NGF and NT-3 protein contents were reduced in hind limb muscles of STZ-induced diabetic rats, consistent with previous works that demonstrated the role of these neurotrophines in DPN (43,44).
Negative_regulation (reduced) of NT-3 protein in limb muscles associated with neurotrophin 3, nerve growth factor, diabetes mellitus and diabetic neuropathy
4) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.68 Pain Relevance 0.51
Cotreatment of LC cultures with morphine and NT-3 resulted in an attenuation of the NT-3 effect on both NE uptake and the number of TH + cells.
Negative_regulation (attenuation) of NT-3 associated with locus ceruleus and morphine
5) Confidence 0.39 Published 1995 Journal Brain Res. Section Abstract Doc Link 8846066 Disease Relevance 0 Pain Relevance 1.14
When 1 microg of NT-3 was locally injected at 5 h after CFA injection at the time NT-3 levels decreased, hyperalgesia was reversed transiently but specifically.
Negative_regulation (decreased) of NT-3 associated with hyperalgesia
6) Confidence 0.38 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10713396 Disease Relevance 0.73 Pain Relevance 0.83
In contrast, receptors for ciliary neurotrophic factor and pleiotrophin were downregulated after avulsion.
Negative_regulation (downregulated) of neurotrophic factor in ciliary
7) Confidence 0.37 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
Co-superfusion with naloxone (0.1 microM), but not CGP 36742 (100 microM), a GABAB antagonist, prevented NT-3 (10 ng/ml) inhibition of SP-LI release.
Negative_regulation (inhibition) of NT-3 associated with antagonist and narcan
8) Confidence 0.36 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334418 Disease Relevance 0.22 Pain Relevance 0.63
Numerous studies have shown that acute and chronic stress significantly reduce neurotrophic factor levels [172,179,180, 190], but most studies have focused on the stress-induced reduction of BDNF levels in the hippocampus [3,10,90,131, 146,155,161,162,165,170].
Negative_regulation (reduce) of neurotrophic factor in hippocampus associated with stress and hippocampus
9) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 1.21 Pain Relevance 0.27
Tianeptine’s ability to prevent the effects of chronic stress on neurogenesis may involve blocking the stress-induced reduction of neurotrophic factor levels in the hippocampus [3].
Negative_regulation (reduction) of neurotrophic factor in hippocampus associated with stress, hippocampus and neurodegenerative disease
10) Confidence 0.31 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 1.07 Pain Relevance 0.38
However, due to this low level of NT3 mRNA produced by transgenic hMSC-NT3 cells, NT3 transgene expression following transplantation of hMSC-NT3 cells in rat spinal cord could not be detected (Figure 3).
Negative_regulation (level) of NT3 in spinal cord associated with targeted disruption and spinal cord
11) Confidence 0.29 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.24 Pain Relevance 0.11
There is the simultaneous down-regulation of genes for a number of neurotrophic factor receptors (Gfra3, Gfra2, Gfra1, Ntrk1, and Adcyap1r1).
Negative_regulation (number) of neurotrophic factor
12) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.31 Pain Relevance 0.04
Similarly, NT-3 contents were significantly decreased in the saline-injected side of STZ-induced diabetic rats (271 ± 46 pg/mg protein, P = 0.0020) compared with those of normal rats (555 ± 161 pg/mg protein), and transplantation of MSCs did not show any effects on the NT-3 contents (Fig. 4B).


Negative_regulation (decreased) of NT-3 associated with neurotrophin 3 and diabetes mellitus
13) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.48 Pain Relevance 0.27
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Negative_regulation (impaired) of nerve growth factor in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
14) Confidence 0.25 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 0.98 Pain Relevance 0.84
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Negative_regulation (impaired) of neurotrophin 3 in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
15) Confidence 0.18 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.03 Pain Relevance 0.85
Continuous infusion is required for suppression of both thermal hyperalgesia and TRPV1 expression, because removal of NT-3 resulted in a prompt reestablishment of the hyperalgesic state and corresponding CCI-associated TRPV1 phenotype.
Negative_regulation (removal) of NT-3 associated with hyperalgesia, eae and thermal hyperalgesia
16) Confidence 0.17 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15659614 Disease Relevance 1.43 Pain Relevance 1.18
NGF and NT-3 in sciatic nerve and substance P and calcitonin gene-related peptide in dorsal root ganglia were decreased in type 1, but not in type 2 rats.
Neg (not) Negative_regulation (decreased) of NT-3 in dorsal root ganglia
17) Confidence 0.16 Published 2005 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 15747389 Disease Relevance 0.05 Pain Relevance 0
When this model was combined by infusion of BDNF or NT-3 to the distal cord stump, axonal growth from the implant into the distal host spinal cord stump was effectively promoted for several cord segments.
Negative_regulation (infusion) of NT-3 in spinal cord associated with spinal cord
18) Confidence 0.15 Published 2007 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1876804 Disease Relevance 0.28 Pain Relevance 0.09
Although chronic morphine exposure resulted in only modest increases in BDNF and NT-3 mRNA expression in LC, precipitated withdrawal led to a marked, rapid, and prolonged increase in BDNF mRNA and a delayed decrease in NT-3 mRNA.
Negative_regulation (decrease) of NT-3 associated with locus ceruleus, withdrawal and morphine
19) Confidence 0.12 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852605 Disease Relevance 0.08 Pain Relevance 1.59
The reduction of neurotrophic factors such as nerve growth factor, neurotrophin-3 or insulin-like growth factors also seems to further diabetic neuropathy.
Negative_regulation (reduction) of neurotrophin-3 in nerve associated with nerve growth factor and diabetic neuropathy
20) Confidence 0.04 Published 2000 Journal Fortschr Neurol Psychiatr Section Abstract Doc Link 10923253 Disease Relevance 1.39 Pain Relevance 0.34

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