INT16256

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2009
Negated 2
Speculated 9
Reported most in Abstract
Documents 15
Total Number 26
Disease Relevance 9.75
Pain Relevance 13.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
glial cell 6
neurons 3
motoneurons 2
muscle 1
CSF 1
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 308 100.00 Very High Very High Very High
neurotrophin 3 45 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
substance P 44 99.96 Very High Very High Very High
Trk A 1 99.96 Very High Very High Very High
antidepressant 8 99.92 Very High Very High Very High
Neuropeptide 12 99.80 Very High Very High Very High
dorsal root ganglion 8 99.58 Very High Very High Very High
Pain 17 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 14 99.82 Very High Very High Very High
Ganglion Cysts 13 99.58 Very High Very High Very High
Pain 13 99.52 Very High Very High Very High
Intracranial Hypertension 72 99.34 Very High Very High Very High
Hypoxia 12 98.96 Very High Very High Very High
Injury 28 98.88 Very High Very High Very High
Diabetes Mellitus 347 98.52 Very High Very High Very High
Hydrocephalus 112 98.28 Very High Very High Very High
Diabetic Neuropathy 177 97.60 Very High Very High Very High
Bacterial Infection 8 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the potential regulation of LC ontogeny by opiates and neurotrophins, we studied the effects of morphine and NT-3, NT-4, and BDNF on the survival and differentiation of LC neurons from prenatal rats in dissociated cell culture.
Regulation (effects) of NT-3 in neurons associated with locus ceruleus, opiate and morphine
1) Confidence 0.49 Published 1995 Journal Brain Res. Section Abstract Doc Link 8846066 Disease Relevance 0 Pain Relevance 0.67
Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain.
Regulation (regulation) of neurotrophic factor in brain associated with neuropeptide
2) Confidence 0.44 Published 1991 Journal Epilepsy Res. Suppl. Section Title Doc Link 1815605 Disease Relevance 0.57 Pain Relevance 0.70
The aim of this study was to investigate the effects of intrathecally delivered trophic molecules nerve growth factor (NGF), neurotrophin-3 (NT-3) and glial cell line-derived neurotrophic factor (GDNF) on substance P (SP) release and content in the rat spinal cord and SP content in sciatic nerve.
Spec (investigate) Regulation (effects) of NT-3 in glial cell associated with nerve growth factor, sciatic nerve, spinal cord and substance p
3) Confidence 0.44 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10651868 Disease Relevance 0 Pain Relevance 0.97
The aim of this study was to investigate the effects of intrathecally delivered trophic molecules nerve growth factor (NGF), neurotrophin-3 (NT-3) and glial cell line-derived neurotrophic factor (GDNF) on substance P (SP) release and content in the rat spinal cord and SP content in sciatic nerve.
Spec (investigate) Regulation (effects) of neurotrophin-3 in glial cell associated with nerve growth factor, sciatic nerve, spinal cord and substance p
4) Confidence 0.44 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10651868 Disease Relevance 0 Pain Relevance 0.97
However, MSC transplantation improved NCV without affecting the protein levels of NGF and NT-3 in hind limb muscles of STZ-induced diabetic rats.
Neg (without) Regulation (affecting) of NT-3 in limb muscles associated with neurotrophin 3, nerve growth factor and diabetes mellitus
5) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.55 Pain Relevance 0.49
The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axotomized group Ia afferents and motoneurons comprising the monosynaptic reflex pathway were investigated.
Spec (investigated) Regulation (effects) of neurotrophin-3 in motoneurons
6) Confidence 0.42 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10191329 Disease Relevance 0 Pain Relevance 0.06
The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axotomized group Ia afferents and motoneurons comprising the monosynaptic reflex pathway were investigated.
Spec (investigated) Regulation (effects) of NT-3 in motoneurons
7) Confidence 0.42 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10191329 Disease Relevance 0 Pain Relevance 0.06
These data demonstrate both an effect of BDNF and NT-3 on serotonergic neurons and an analgesic property of these neurotrophins which appears to involve both serotonin and opioid mechanisms.
Regulation (effect) of NT-3 in serotonergic neurons associated with analgesic, opioid and serotonin
8) Confidence 0.38 Published 1994 Journal Brain Res. Section Abstract Doc Link 7511037 Disease Relevance 0 Pain Relevance 0.67
We assume that the NGF and NT-3 concentrations measured are probably a reflection of the average pressure increase over several days rather than the actual pressure at the time the sample was taken.
Regulation (reflection) of NT-3 associated with nerve growth factor
9) Confidence 0.36 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.52 Pain Relevance 0.52
For analysis of real-time PCR data, expression levels of EGFP and NT3 were calculated versus expression of GAPDH.


Regulation (calculated) of NT3
10) Confidence 0.30 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.07 Pain Relevance 0
NGF and NT-3 concentrations were similar in first and repeat CSF samples, and no significant differences emerged between samples with elevated and near-normal pressure at the time of CSF sampling (Table 2).
Regulation (concentrations) of NT-3 associated with nerve growth factor
11) Confidence 0.25 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.59 Pain Relevance 0.58
We investigated whether concentrations of NGF and NT-3 are increased in the CSF of children with hydrocephalus.


Spec (whether) Regulation (concentrations) of NT-3 in CSF associated with nerve growth factor and hydrocephalus
12) Confidence 0.25 Published 2001 Journal BMC Pediatr Section Abstract Doc Link PMC57003 Disease Relevance 0.98 Pain Relevance 0.51
Hypothesising that changes of neurotrophin production in response to elevated ICP may be reflected in altered CSF concentrations of NGF and NT-3, we set out to measure these neurotrophins in children who underwent ventricular taps or shunt placement surgery for hydrocephalus.


Regulation (concentrations) of NT-3 associated with nerve growth factor, hydrocephalus and cva
13) Confidence 0.25 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 1.37 Pain Relevance 0.38
Here, we examined the regulation of receptors for brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, and pleiotrophin after root avulsion in adult rats.
Spec (examined) Regulation (regulation) of neurotrophic factor in glial cell
14) Confidence 0.24 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
Here, we examined the regulation of receptors for brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, and pleiotrophin after root avulsion in adult rats.
Spec (examined) Regulation (regulation) of neurotrophic factor in glial cell
15) Confidence 0.24 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
Thus, the influence of NT-3 on phenotypic changes in dorsal root ganglion (DRG) neurons in rats coincident with CCI was examined using in situ hybridization.
Spec (examined) Regulation (influence) of NT-3 in neurons associated with ganglion cysts, dorsal root ganglion and eae
16) Confidence 0.23 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.13 Pain Relevance 0.94
The present study examines whether there is a global influence of NT-3 in mitigating alterations in peptide and NGF receptor expression; molecules believed to also contribute to CCI-associated pain.
Spec (whether) Regulation (influence) of NT-3 associated with pain, nerve growth factor and eae
17) Confidence 0.23 Published 2006 Journal Neuroscience Section Abstract Doc Link 16843605 Disease Relevance 1.01 Pain Relevance 0.88
Intraventricularly-administered glial cell line-derived neurotrophic factor did not reverse lesion-induced increases in nigral dynorphin A or met-enkephalin levels nor did glial cell line-derived neurotrophic factor affect substance P levels in the striatum.
Regulation (affect) of neurotrophic factor in glial cell associated with dynorphin, enkephalin and substance p
18) Confidence 0.19 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135089 Disease Relevance 0.05 Pain Relevance 0.63
The recoveries of exogenous NGF and NT-3 added to soleus muscle homogenates were measured, and the concentrations of NGF and NT-3 were calculated, taking into account the recoveries.
Regulation (concentrations) of NT-3 in muscle associated with neurotrophin 3 and nerve growth factor
19) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0 Pain Relevance 0.54
Alterations of BDNF and NT-3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal.
Regulation (Alterations) of NT-3 in nucleus associated with withdrawal and morphine
20) Confidence 0.19 Published 2007 Journal Neuropeptides Section Title Doc Link 17688944 Disease Relevance 0.23 Pain Relevance 1.47

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