INT162564

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT2) cytoplasm (KRT2)
Anatomy Link Frequency
nail 1
hair follicle 1
upper 1
KRT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 99.20 Very High Very High Very High
Pain 6 96.92 Very High Very High Very High
medulla 21 40.80 Quite Low
Inflammation 22 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Deafness 1 100.00 Very High Very High Very High
Neurofibromatosis 1 100.00 Very High Very High Very High
Ectodermal Dysplasia 3 99.36 Very High Very High Very High
Rare Diseases 3 98.80 Very High Very High Very High
Cancer 258 97.20 Very High Very High Very High
Skin Appendage Disease 9 96.68 Very High Very High Very High
Disease 40 95.84 Very High Very High Very High
Monilethrix 9 95.32 Very High Very High Very High
Acoustic Neuroma 1 92.24 High High
Apoptosis 37 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Being widely distributed over most body sites, this type II keratin is expressed late, at an advanced stage of differentiation, in the uppermost epidermal layers (upper stratum spinosum, stratum granulosum) to a variable extent (Collin et al. 1992a).
Gene_expression (expressed) of type II in upper
1) Confidence 0.59 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.27 Pain Relevance 0
Surprisingly, there were much more epithelial keratins with hair follicle specificity, namely the type II keratins K6irs1, K6irs2, K6irs3 and K6irs4 (now K71–K74) and type I keratins K25irs1, K25irs2, K25irs3 and K25irs4 (now K25–K28), all of them specifically expressed in and closely restricted to the various compartments of the hair follicle inner root sheath (Langbein et al. 2002, 2003, 2006; for review see Langbein and Schweizer 2005).
Gene_expression (expressed) of type II in hair follicle
2) Confidence 0.59 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
A further, rare disease recently found to be related to a distinct mutation in the type II hair keratin K85 is ectodermal dysplasia of hair and nail type, characterized by total alopecia and severe nail dystrophy (Naeem et al. 2006).
Gene_expression (hair) of type II in nail associated with rare diseases, skin appendage disease and ectodermal dysplasia
3) Confidence 0.52 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.78 Pain Relevance 0
He had no family history of neurofibromatosis type II (NF II), no history of hearing loss or vestibular problems, and no symptoms of NF I.
Neg (no) Gene_expression (symptoms) of neurofibromatosis type II associated with deafness and neurofibromatosis
4) Confidence 0.33 Published 2009 Journal J. Dermatol. Section Abstract Doc Link 19712279 Disease Relevance 0.56 Pain Relevance 0.24
While gene expression of collagen type-I and type-II was nearly unaffected, aggrecan gene expression was elevated by 1.75 fold (p = 0.45) in treatment samples with respect to control samples of the same patients.
Gene_expression (expression) of type-II
5) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.14 Pain Relevance 0

General Comments

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