INT16257

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.00
Pain Relevance 5.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
dentate gyrus 2
nerve 2
brain 2
nucleus 2
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 75 100.00 Very High Very High Very High
bDMF 29 100.00 Very High Very High Very High
Neuropeptide 21 100.00 Very High Very High Very High
cva 19 99.58 Very High Very High Very High
neurotrophin 3 9 99.52 Very High Very High Very High
antidepressant 6 98.52 Very High Very High Very High
Morphine 8 98.20 Very High Very High Very High
Desipramine 4 98.16 Very High Very High Very High
Enkephalin 3 97.56 Very High Very High Very High
fluoxetine 6 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 31 100.00 Very High Very High Very High
Intracranial Hypertension 18 99.58 Very High Very High Very High
Hydrocephalus 28 95.68 Very High Very High Very High
Opiate Addiction 3 95.12 Very High Very High Very High
Bacterial Meningitis 1 92.84 High High
Stress 9 91.68 High High
Brain Injury 3 88.96 High High
Hyperalgesia 4 85.44 High High
Hyperglycemia 8 79.44 Quite High
Hypoglycemia 2 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations of BDNF and NT-3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal.
Regulation (Alterations) of Gene_expression (expression) of NT-3 in nucleus associated with withdrawal and morphine
1) Confidence 0.43 Published 2007 Journal Neuropeptides Section Title Doc Link 17688944 Disease Relevance 0.23 Pain Relevance 1.48
Hypothesising that changes of neurotrophin production in response to elevated ICP may be reflected in altered CSF concentrations of NGF and NT-3, we set out to measure these neurotrophins in children who underwent ventricular taps or shunt placement surgery for hydrocephalus.


Regulation (altered) of Gene_expression (concentrations) of NT-3 associated with nerve growth factor, hydrocephalus and cva
2) Confidence 0.41 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 1.37 Pain Relevance 0.38
Here we describe the influence of limbic seizures upon the expression of nerve growth factor (NGF), 2 related neurotrophic factors, brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), and several neuropeptides (enkephalin, dynorphin, and neuropeptide Y) in the rat forebrain.
Regulation (influence) of Gene_expression (expression) of neurotrophic factor in nerve associated with convulsion, dynorphin, neurotrophin 3, nerve growth factor, neuropeptide, enkephalin and bdmf
3) Confidence 0.39 Published 1991 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1815605 Disease Relevance 0.61 Pain Relevance 0.74
The gene expression for NT-3, which is distributed in a high density in the dentate gyrus, was not affected by single or repeated injections of antidepressant drugs (TCP, fluoxetine, paroxetine, sertraline, desipramine, maprotiline or mianserin) at 4 or 24 h post drug.
Neg (not) Regulation (affected) of Gene_expression (expression) of NT-3 in dentate gyrus associated with desipramine, antidepressant and fluoxetine
4) Confidence 0.32 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726822 Disease Relevance 0 Pain Relevance 1.28
For analysis of real-time PCR data, expression levels of EGFP and NT3 were calculated versus expression of GAPDH.


Regulation (calculated) of Gene_expression (expression) of NT3
5) Confidence 0.30 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.07 Pain Relevance 0
Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain.
Regulation (regulation) of Gene_expression (expression) of neurotrophic factor in brain associated with neuropeptide
6) Confidence 0.27 Published 1991 Journal Epilepsy Res. Suppl. Section Title Doc Link 1815605 Disease Relevance 0.58 Pain Relevance 0.71
The time courses and cellular specificities of these alterations in neurotrophic factor expression are discussed and contrasted with seizure-induced changes in neuropeptide expression.
Regulation (alterations) of Gene_expression (expression) of neurotrophic factor associated with convulsion and neuropeptide
7) Confidence 0.23 Published 1991 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1815605 Disease Relevance 0.59 Pain Relevance 0.75
on the expression of several neurotrophic factors such as NGF, IGF-1, and NT-3
Regulation (on) of Gene_expression (expression) of NT-3 associated with nerve growth factor
8) Confidence 0.13 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.56 Pain Relevance 0.28

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