INT162574

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.92
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Wnt5a) signal transduction (Wnt5a) extracellular space (Wnt5a)
extracellular region (Wnt5a) proteinaceous extracellular matrix (Wnt5a) plasma membrane (Wnt5a)
Anatomy Link Frequency
chondrocytes 2
mononuclear cells 1
Wnt5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 71.92 Quite High
Inflammation 11 68.44 Quite High
chemokine 2 54.60 Quite High
Snapping jaw 12 50.00 Quite Low
metalloproteinase 12 50.00 Quite Low
Multiple sclerosis 1 12.44 Low Low
agonist 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 3 97.48 Very High Very High Very High
Temporomandibular Joint Syndrome 12 93.24 High High
Adhesions 1 89.92 High High
Fracture Healing 36 73.20 Quite High
INFLAMMATION 21 71.92 Quite High
Osteoporosis 34 43.88 Quite Low
Cancer 2 25.84 Quite Low
Necrosis 2 25.36 Quite Low
Demyelinating Disease 1 12.44 Low Low
Multiple Sclerosis 1 11.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our results do not exclude the possibility that noncanonical WNT pathways are also likely activated during fracture repair, as WNT5a and WNT11 can signal through the WNT/Ca2+ pathway, which regulates Ca2+ flux and Ca2+-sensitive protein kinases and transcription factors, such as PKC?
Gene_expression (signal) of WNT5a
1) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.14 Pain Relevance 0
In human macrophages, WNT5A expression was up-regulated by TLR ligands, as well as challenge with M. tuberculosis and M. avium, and the WNT5A/Frizzled-5 (FZD5) pathway promoted IL-12 production from peripheral blood mononuclear cells [52].
Gene_expression (expression) of WNT5A in mononuclear cells associated with mycobacterial infection
2) Confidence 0.32 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.33 Pain Relevance 0.10
Purified Wnt-5A protein and transfection with Wnt-5A expression vector promoted the expression of MMP-1, MMP-3, MMP-9, and MMP-13.
Gene_expression (transfection) of Wnt-5A
3) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.07 Pain Relevance 0
Expression of Wnt-5A, MMP-1, MMP-3, MMP-9, MMP-13, and type II collagen, as well as cell morphologic changes, were examined.
Spec (examined) Gene_expression (Expression) of Wnt-5A
4) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.09 Pain Relevance 0
Purified Wnt-5A protein and transfection with Wnt-5A expression vector promoted the expression of MMP-1, MMP-3, MMP-9, and MMP-13.
Gene_expression (expression) of Wnt-5A
5) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.07 Pain Relevance 0
METHODS: Primary rabbit condylar chondrocytes were treated with IL-1beta, purified Wnt-5A protein, or both and transfected with Wnt-5A expression vector.
Gene_expression (expression) of Wnt-5A in chondrocytes
6) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.09 Pain Relevance 0
RESULTS: Treatment of rabbit condylar chondrocytes with IL-1beta up-regulated Wnt-5A expression.
Gene_expression (expression) of Wnt-5A in chondrocytes
7) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.07 Pain Relevance 0
Purified Wnt-5A protein and transfection with Wnt-5A expression vector promoted the expression of MMP-1, MMP-3, MMP-9, and MMP-13.
Gene_expression (transfection) of Wnt-5A
8) Confidence 0.03 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.07 Pain Relevance 0

General Comments

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