INT162576

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.71
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Wnt5a) signal transduction (Wnt5a) extracellular space (Wnt5a)
extracellular region (Wnt5a) proteinaceous extracellular matrix (Wnt5a) plasma membrane (Wnt5a)
Wnt5a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 99.80 Very High Very High Very High
antagonist 9 60.80 Quite High
metalloproteinase 2 50.00 Quite Low
Snapping jaw 2 50.00 Quite Low
Serotonin 7 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fracture Healing 77 99.54 Very High Very High Very High
Congenital Anomalies 4 91.28 High High
Targeted Disruption 8 74.12 Quite High
Temporomandibular Joint Syndrome 2 73.96 Quite High
Osteoporosis 78 62.36 Quite High
Syndactyly 2 47.28 Quite Low
Craniofacial Abnormalities 1 42.40 Quite Low
Cancer 4 14.72 Low Low
Familial Adenomatous Polyposis 3 14.48 Low Low
Tibia Fractures 6 7.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, in our study, we not only noticed that WNT11 was expressed during fracture healing, but also observed an activation of both WNT5a and its mediator PKC?.
Positive_regulation (activation) of WNT5a associated with fracture healing
1) Confidence 0.48 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.15 Pain Relevance 0
Overexpression of Lrp6 blocks activation of the Wnt5a-target, Rac, and this effect is dependent on intact Lrp6 extracellular domains.
Positive_regulation (activation) of Wnt5a
2) Confidence 0.26 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.09 Pain Relevance 0
Furthermore, we also observed an up-regulation of WNT5a and protein kinase C alpha (PKC?)
Positive_regulation (up-regulation) of WNT5a associated with kinase c
3) Confidence 0.14 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1950214 Disease Relevance 0.39 Pain Relevance 0.08
SP600125, a JNK inhibitor, was used to investigate the role of the JNK pathway in Wnt-5A induction of MMP-1, MMP-3, MMP-9, and MMP-13.
Spec (investigate) Positive_regulation (induction) of Wnt-5A
4) Confidence 0.02 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19714632 Disease Relevance 0.07 Pain Relevance 0

General Comments

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