INT16258

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 0
Speculated 10
Reported most in Abstract
Documents 121
Total Number 134
Disease Relevance 53.93
Pain Relevance 59.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
spinal cord 15
nerve 14
brain 13
glial cell 7
neurons 6
Ntf3 (Rattus norvegicus)
Ntf3 - D15A (1)
Pain Link Frequency Relevance Heat
Nerve growth factor 1070 100.00 Very High Very High Very High
bDMF 311 100.00 Very High Very High Very High
Central nervous system 111 100.00 Very High Very High Very High
Neuropeptide 86 100.00 Very High Very High Very High
neurotrophin 3 57 100.00 Very High Very High Very High
Sciatic nerve 28 100.00 Very High Very High Very High
Trk A 4 99.92 Very High Very High Very High
withdrawal 60 99.86 Very High Very High Very High
Inflammation 300 99.84 Very High Very High Very High
Locus ceruleus 80 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 197 100.00 Very High Very High Very High
Apoptosis 184 100.00 Very High Very High Very High
Aids-related Complex 10 100.00 Very High Very High Very High
INFLAMMATION 375 99.84 Very High Very High Very High
Convulsion 71 99.80 Very High Very High Very High
Herpes Simplex Virus 6 99.70 Very High Very High Very High
Brain Injury 38 99.68 Very High Very High Very High
Diabetes Mellitus 167 99.66 Very High Very High Very High
Urinary Dysfunction 129 99.56 Very High Very High Very High
Ganglion Cysts 91 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, NT-3 produces synapse-specific and age-dependent LTP-like enhancement of AMPA/kainate receptor-mediated synaptic transmission in the spinal cord, and this action requires the availability of functional NMDA receptors in the motoneuron.
Gene_expression (produces) of NT-3 in motoneuron associated with nmda receptor, long-term potentiation and spinal cord
1) Confidence 0.78 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10938302 Disease Relevance 0 Pain Relevance 0.50
In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated gene transfer of neurotrophin-3.
Gene_expression (transfer) of neurotrophin-3 associated with herpes simplex virus, induced neuropathy and neuropathic pain
2) Confidence 0.78 Published 2002 Journal Ann. Neurol. Section Title Doc Link 11782980 Disease Relevance 0.70 Pain Relevance 0.22
We used peripheral subcutaneous inoculation with a replication-incompetent, genomic herpes simplex virus-based vector containing the coding sequence for neurotrophin-3 to transduce sensory neurons of the rat dorsal root ganglion in vivo, and found that expression of neurotrophin-3 from the vector protected peripheral sensory axons from neuropathy induced by intoxication with pyridoxine assessed by electrophysiological (foot sensory response amplitude, and conduction velocity, and H-wave), histological (nerve morphology and morphometry), and behavioral measures of proprioceptive function.
Gene_expression (expression) of neurotrophin-3 in sensory neurons associated with ganglion cysts, dorsal root ganglion, herpes simplex virus, neuropathic pain and poisoning
3) Confidence 0.78 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11782980 Disease Relevance 0.71 Pain Relevance 0.20
To determine whether growth factors of the neurotrophin family are able to prevent the degeneration of striatal projection neurons, cell lines expressing brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4/5 (NT-4/5) were grafted in the adult rat striatum before quinolinate injection.
Gene_expression (expressing) of neurotrophin-3 in brain associated with projection neuron
4) Confidence 0.75 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11183872 Disease Relevance 0.33 Pain Relevance 0.12
To determine whether growth factors of the neurotrophin family are able to prevent the degeneration of striatal projection neurons, cell lines expressing brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4/5 (NT-4/5) were grafted in the adult rat striatum before quinolinate injection.
Gene_expression (expressing) of NT-3 in brain associated with projection neuron
5) Confidence 0.75 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11183872 Disease Relevance 0.33 Pain Relevance 0.12
These findings were associated with preventive effects on impaired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prevention of perturbed expression of insulin, insulin growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.
Gene_expression (expression) of neurotrophin 3 in nerve associated with ganglion cysts, dorsal root ganglion, neurotrophin 3, nerve growth factor and sciatic nerve
6) Confidence 0.75 Published 2004 Journal Ann. Neurol. Section Abstract Doc Link 15497155 Disease Relevance 1.17 Pain Relevance 0.86
We hypothesize that deficits in neurotrophic factor support, specifically linked to diabetes-induced lowered expression of insulin and neurotrophin-3, triggers alterations of sensory neurone phenotype that are critical for the development of abnormal Ca(2+) homeostasis and associated mitochondrial dysfunction.
Gene_expression (expression) of neurotrophin-3 associated with parkinson's disease and diabetes mellitus
7) Confidence 0.74 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18191198 Disease Relevance 1.17 Pain Relevance 0.05
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Gene_expression (synthesis) of NT3 in nerve associated with nervous system injury and nerve growth factor
8) Confidence 0.74 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.60 Pain Relevance 0.38
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Gene_expression (synthesis) of neurotrophin-3 in nerve associated with nervous system injury and nerve growth factor
9) Confidence 0.74 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.60 Pain Relevance 0.39
Alterations of BDNF and NT-3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal.
Gene_expression (expression) of NT-3 in nucleus associated with withdrawal and morphine
10) Confidence 0.74 Published 2007 Journal Neuropeptides Section Title Doc Link 17688944 Disease Relevance 0.23 Pain Relevance 1.48
Results showed that chronic administration of morphine significantly increased BDNF and NT-3 gene expression in PGi.
Gene_expression (expression) of NT-3 gene associated with bdmf and morphine
11) Confidence 0.74 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.14 Pain Relevance 1.65
The present study was designed to evaluate the expression of BDNF and NT-3 in the context of opiate dependence and withdrawal in PGi.
Gene_expression (expression) of NT-3 associated with addiction, opiate, withdrawal and bdmf
12) Confidence 0.74 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.26 Pain Relevance 1.66
In the present study, we examined the expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) mRNAs in the DRG after a peripheral nerve injury.
Spec (examined) Gene_expression (expression) of NT-3 in peripheral nerve associated with dorsal root ganglion, nervous system injury, neurotrophin 3, nerve growth factor and peripheral nerve injury
13) Confidence 0.72 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9931485 Disease Relevance 0.73 Pain Relevance 0.71
In the present study, we examined the expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3) mRNAs in the DRG after a peripheral nerve injury.
Spec (examined) Gene_expression (expression) of neurotrophin 3 in peripheral nerve associated with dorsal root ganglion, nervous system injury, neurotrophin 3, nerve growth factor and peripheral nerve injury
14) Confidence 0.72 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9931485 Disease Relevance 0.73 Pain Relevance 0.71
The expression of NT-3 mRNA was not detected either in normal or nerve injured rats.
Gene_expression (expression) of NT-3 mRNA in nerve associated with neurotrophin 3
15) Confidence 0.72 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9931485 Disease Relevance 0.62 Pain Relevance 0.68
We propose that increased NGF and NT-3 production represent adaptive responses of the brain to prolonged elevated ICP.


Gene_expression (production) of NT-3 in brain associated with nerve growth factor and cva
16) Confidence 0.71 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.79 Pain Relevance 0.64
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Gene_expression (source) of NT-3 in oligodendrocytes associated with nerve growth factor
17) Confidence 0.71 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.56 Pain Relevance 0.73
Figure 1 shows the relative gene expression of NGF, BDNF and NT-3 in NSC culture at passages 5-7 in three separate experiments.
Gene_expression (expression) of NT-3 associated with nerve growth factor
18) Confidence 0.71 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0 Pain Relevance 0.22
Here we describe the influence of limbic seizures upon the expression of nerve growth factor (NGF), 2 related neurotrophic factors, brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), and several neuropeptides (enkephalin, dynorphin, and neuropeptide Y) in the rat forebrain.
Gene_expression (expression) of neurotrophic factor in nerve associated with convulsion, dynorphin, neurotrophin 3, nerve growth factor, neuropeptide, enkephalin and bdmf
19) Confidence 0.67 Published 1991 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1815605 Disease Relevance 0.60 Pain Relevance 0.74
PGi nucleus was assayed for the expression of BDNF and NT-3 using semi-quantitative RT-PCR normalized to beta-actin gene expression.
Gene_expression (expression) of NT-3 in nucleus associated with bdmf
20) Confidence 0.64 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.21 Pain Relevance 1.87

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