INT16259

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2011
Negated 19
Speculated 9
Reported most in Abstract
Documents 336
Total Number 361
Disease Relevance 183.48
Pain Relevance 209.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 38
spinal cord 26
neurons 25
hippocampus 20
nerve 12
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 9892 100.00 Very High Very High Very High
Spinal cord 3627 100.00 Very High Very High Very High
Pain 1957 100.00 Very High Very High Very High
Hippocampus 1777 100.00 Very High Very High Very High
fluoxetine 1385 100.00 Very High Very High Very High
Sciatic nerve 1245 100.00 Very High Very High Very High
Nerve growth factor 1071 100.00 Very High Very High Very High
long-term potentiation 933 100.00 Very High Very High Very High
antagonist 599 100.00 Very High Very High Very High
nMDA receptor 339 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 2912 100.00 Very High Very High Very High
Stress 1989 100.00 Very High Very High Very High
Anxiety Disorder 785 100.00 Very High Very High Very High
Aids-related Complex 472 100.00 Very High Very High Very High
Urological Neuroanatomy 138 100.00 Very High Very High Very High
Sleep Disorders 53 100.00 Very High Very High Very High
Sciatic Neuropathy 418 99.98 Very High Very High Very High
Convulsion 256 99.98 Very High Very High Very High
Depression 1705 99.96 Very High Very High Very High
Nervous System Injury 391 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, in agreement with previous studies, fluoxetine increased BDNF mRNA levels in the hippocampus, an effect that was limited to the cell bodies without any change in its dendritic targeting.
Positive_regulation (increased) of BDNF mRNA in hippocampus associated with hippocampus and fluoxetine
1) Confidence 0.70 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035958 Disease Relevance 0.13 Pain Relevance 0.75
Our data suggest that chronic treatment with the novel antidepressant duloxetine not only produces a marked upregulation of BDNF mRNA and protein, but may also affect the subcellular redistribution of the neurotrophin.
Positive_regulation (upregulation) of BDNF mRNA associated with antidepressant and duloxetine
2) Confidence 0.70 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17327885 Disease Relevance 0.15 Pain Relevance 0.63
Since the BDNF gene has been reported to be upregulated by antidepressants, the expression of the four BDNF mRNA isoforms was measured by real-time quantitative RT-PCR in rat hippocampi after chronic and acute treatment with the antidepressant drug fluoxetine and GR205171, a selective NK-1 receptor antagonist with anxiolytic-like properties.
Positive_regulation (upregulated) of BDNF gene associated with antidepressant, antagonist, anxiety disorder and fluoxetine
3) Confidence 0.70 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053962 Disease Relevance 0.18 Pain Relevance 0.37
Transection of the sciatic nerve induced the up-regulation of BDNF mRNA.
Positive_regulation (regulation) of BDNF in sciatic nerve associated with sciatic nerve
4) Confidence 0.70 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.26 Pain Relevance 0.46
Whilst 7 days of treatment showed a non-significant increase in BDNF mRNA, there were marked and region-specific increases following 14 days of treatment.
Positive_regulation (increase) of BDNF
5) Confidence 0.70 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.69
The BDNF gene consists of nine 5' noncoding exons each linked to individual promoter regions and a 3' coding exon (IX), which codes for the BDNF preprotein amino acid sequence.30,31 Several recent studies have examined differential usage of BDNF non-coding exons during consolidation of fear learning.3,32,33 In these earlier studies, BDNF exons I and IV were transcriptionally upregulated in the amygdala during consolidation of fear learning.32,33 Bredy and colleagues34 showed that extinction of conditioned fear is accompanied by a significant increase in histone H4 acetylation at the promoter of exon IV of the BDNF gene and an increase in exon I and IV mRNA of the BDNF gene in the prefrontal cortex of mice.
Positive_regulation (increase) of BDNF in amygdala associated with anxiety disorder and amygdala
6) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.73 Pain Relevance 0.13
Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus.
Positive_regulation (enhancement) of BDNF in brain associated with stress, anxiety disorder and hippocampus
7) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Abstract Doc Link PMC3022311 Disease Relevance 0.74 Pain Relevance 0.05
They observed a selective increase in histone H3 acetylation at the BDNF gene promoter of exon IV, and a selective decrease in histone H4 acetylation at the BDNF promoter of exon II.
Positive_regulation (increase) of BDNF
8) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.29 Pain Relevance 0.08
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Positive_regulation (increase) of BDNF in hippocampus associated with convulsion, status epilepticus and hippocampus
9) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.63 Pain Relevance 0.12
Consistent with the mRNA expression pattern, BDNF protein was also mainly upregulated in all populations of sensory neurons in the ipsilateral L5 DRG and in spinal neurons and glia.
Positive_regulation (upregulated) of BDNF protein in sensory neurons
10) Confidence 0.70 Published 2006 Journal Neurotox Res Section Abstract Doc Link 16782586 Disease Relevance 0.44 Pain Relevance 0.56
BDNF mRNA levels in the dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, indicating that stimulation of BDNF mRNA expression is dependent on the pharmacological profile and on the time-course of drug treatment.
Neg (not) Positive_regulation (increased) of BDNF in dentate gyrus associated with fluoxetine
11) Confidence 0.70 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.66
L5 ventral rhizotomy and spinal nerve transection produced not only mechanical and heat hypersensitivity, but also an increase in brain-derived neurotrophic factor mRNA/protein in the L5 dorsal root ganglion at 7 days after surgery.
Positive_regulation (increase) of brain-derived neurotrophic factor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and hypersensitivity
12) Confidence 0.70 Published 2006 Journal Neuroscience Section Abstract Doc Link 16326015 Disease Relevance 1.35 Pain Relevance 1.00
Similarly, the amount of BDNF released by burst stimulation was increased after NGF treatment.
Positive_regulation (increased) of BDNF
13) Confidence 0.70 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11404434 Disease Relevance 0 Pain Relevance 0.88
Levels of BDNF and trkB mRNAs were increased in the hippocampus in a dose-dependent fashion following the stimulations.
Positive_regulation (increased) of BDNF in hippocampus associated with hippocampus
14) Confidence 0.70 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.71
To test this hypothesis we have investigated if increases in BDNF and trkB mRNAs are associated with changes in the synaptic release of glutamate in the dorsal hippocampus in the conscious rat by combining the technique of in vivo microdialysis with in situ hybridization histochemistry.
Spec (investigated) Positive_regulation (increases) of BDNF in hippocampus associated with glutamate and hippocampus
15) Confidence 0.70 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.46
In contrast, chronic administration of nonantidepressant psychotropic drugs, including morphine, cocaine, or haloperidol, did not increase levels of BDNF mRNA.
Neg (not) Positive_regulation (increase) of BDNF mRNA associated with cocaine and morphine
16) Confidence 0.70 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 0.91 Pain Relevance 0.52
Chronic (21 d), but not acute (1 d), administration of several different antidepressant drugs, including tranylcypromine, sertraline, desipramine, or mianserin, significantly increased BDNF mRNA and all but mianserin increased trkB mRNA in hippocampus.
Positive_regulation (increased) of BDNF mRNA in hippocampus associated with desipramine, antidepressant and hippocampus
17) Confidence 0.70 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.52
In the dentate gyrus granule cell layer, chronic ECS decreased the acute induction of BDNF and trkB mRNA by approximately 50%, but prolonged their expression: levels remained elevated two- to threefold 18 hr later after the last chronic ECS treatment, but returned to control 18 hr after acute ECS.
Positive_regulation (induction) of BDNF in dentate gyrus granule cell layer associated with convulsion
18) Confidence 0.70 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472505 Disease Relevance 1.03 Pain Relevance 0.19
Peripheral tissue inflammation produced by an intraplantar injection of Freund's adjuvant into the paws significantly increased BDNF mRNA levels in the DRG and many neurons expressing trkA mRNA showed increased expession of BDNF mRNA.
Positive_regulation (increased) of BDNF mRNA in DRG associated with dorsal root ganglion and inflammation
19) Confidence 0.70 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.86 Pain Relevance 0.74
Intraplantar injection of antibody to NGF together with Freund's adjuvant prevented the increase in BDNF mRNA.
Positive_regulation (increase) of BDNF mRNA associated with nerve growth factor
20) Confidence 0.70 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.79 Pain Relevance 0.73

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