INT16260

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2011
Negated 7
Speculated 21
Reported most in Abstract
Documents 671
Total Number 698
Disease Relevance 283.44
Pain Relevance 339.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 104
neurons 53
hippocampus 34
spinal cord 33
DRG 28
Bdnf (Rattus norvegicus)
Bdnf - V66M (1)
Pain Link Frequency Relevance Heat
bDMF 12617 100.00 Very High Very High Very High
Spinal cord 6496 100.00 Very High Very High Very High
Sciatic nerve 2722 100.00 Very High Very High Very High
depression 2530 100.00 Very High Very High Very High
antidepressant 2299 100.00 Very High Very High Very High
Pain 2107 100.00 Very High Very High Very High
long-term potentiation 1627 100.00 Very High Very High Very High
Nerve growth factor 1438 100.00 Very High Very High Very High
Central nervous system 1014 100.00 Very High Very High Very High
Inflammation 981 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 3434 100.00 Very High Very High Very High
Neuropathic Pain 1382 100.00 Very High Very High Very High
Nociception 1110 100.00 Very High Very High Very High
Affective Disorder 117 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 49 100.00 Very High Very High Very High
Drug Dependence 32 100.00 Very High Very High Very High
Cv Unclassified Under Development 1417 99.96 Very High Very High Very High
Nervous System Injury 658 99.96 Very High Very High Very High
Aids-related Complex 585 99.96 Very High Very High Very High
Hyperalgesia 320 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in BDNF gene expression correlate with rat strain differences in neuropathic pain.
Gene_expression (expression) of BDNF associated with pain, neuropathic pain and sprains and strains
1) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Title Doc Link 17556103 Disease Relevance 1.10 Pain Relevance 1.05
A significant upregulation of BDNF gene expression was found only in injured DRG of F344 rats, thus correlating with higher resistance to neuropathic pain.
Gene_expression (expression) of BDNF in DRG associated with neuropathic pain
2) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.18 Pain Relevance 0.92
Since brain-derived neutrophic factor (BDNF) modulates both the endogenous opioid and noradrenergic systems, we have now studied specific changes in BDNF gene expression related to the maintenance of neuropathic pain in the three rat strains.
Gene_expression (expression) of BDNF in brain associated with neuropathic pain, endogenous opioid and sprains and strains
3) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.14 Pain Relevance 0.88
Real time RT-PCR studies revealed minimal changes in the expression of BDNF in the spinal cord after CCI despite the strain considered, but marked changes in dorsal root ganglia (DRG) were observed.
Gene_expression (expression) of BDNF in dorsal root ganglia associated with eae, sprains and strains and spinal cord
4) Confidence 0.78 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17556103 Disease Relevance 1.23 Pain Relevance 0.95
These data show that chronic treatment with fluoxetine increases BDNF gene expression not only in limbic areas but also in dopaminergic regions, suggesting that such an effect may contribute to improve the function of the dopaminergic system in depressed subjects.
Gene_expression (expression) of BDNF gene associated with fluoxetine
5) Confidence 0.78 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16035958 Disease Relevance 0.07 Pain Relevance 0.69
Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions.
Gene_expression (expression) of BDNF mRNA associated with fluoxetine
6) Confidence 0.78 Published 2006 Journal Int. J. Neuropsychopharmacol. Section Title Doc Link 16035958 Disease Relevance 0.16 Pain Relevance 0.47
Results demonstrate that BDNF gene expression in certain brain structures is inhibited by inflammatory pain, yet estrogen may enhance central nervous system sensitization associated with sensory processing.
Gene_expression (expression) of BDNF gene in brain structures associated with ipn and central nervous system
7) Confidence 0.78 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 0.90 Pain Relevance 0.68
Since alterations in BDNF gene expression in higher brain centers may be relevant to cognitive changes that occur in recurrent depression, these results may provide insights into the coincidence of chronic pain and depression.
Gene_expression (expression) of BDNF gene in brain associated with cognitive disorder, depression and lasting pain
8) Confidence 0.78 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.04 Pain Relevance 0.66
The pain-evoked up-regulation of spinal BDNF gene expression was significantly potentiated by concomitant estrogen treatment.
Gene_expression (expression) of BDNF gene in spinal associated with pain
9) Confidence 0.78 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 0.97 Pain Relevance 0.72
Thus, BDNF gene expression was quantified in intact female rats in proestrus and diestrus, and in ovariectomized (OVX) rats with or without 17beta-estradiol (E2) replacement following intraplantar injection of dilute formalin as an inflammatory nociceptive stimulus.
Gene_expression (expression) of BDNF gene associated with nociception and inflammation
10) Confidence 0.78 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16020928 Disease Relevance 1.15 Pain Relevance 0.59
However, the co-expression of BDNF and vanilloid receptor 1-like receptor was very rare (less than 1%).
Gene_expression (expression) of BDNF
11) Confidence 0.78 Published 2006 Journal Brain Res. Section Abstract Doc Link 16510129 Disease Relevance 0.62 Pain Relevance 0.51
After transfection of the rat BDNF gene into RN46A cells, an autocrine BDNF-secreting cell line, 46A-B14, was isolated and transplanted into the rat CNS.
Gene_expression (transfection) of BDNF gene
12) Confidence 0.78 Published 1997 Journal Pain Section Abstract Doc Link 9272788 Disease Relevance 0.47 Pain Relevance 0.48
BDNF gene expression in these neurons was down-regulated after application of capsaicin to the sciatic nerve.
Gene_expression (expression) of BDNF gene in sciatic nerve associated with qutenza and sciatic nerve
13) Confidence 0.78 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.28 Pain Relevance 0.45
However, the changes in BDNF gene expression in dorsal root ganglion (DRG) neurons after axotomy are not known.
Gene_expression (expression) of BDNF gene in DRG associated with ganglion cysts and dorsal root ganglion
14) Confidence 0.78 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.28 Pain Relevance 0.39
These results suggest that up- and down-regulation of BDNF gene expression in distinct subgroups of rat DRG neurons are caused by damage to the peripheral nerve.
Gene_expression (expression) of BDNF gene in peripheral nerve associated with dorsal root ganglion
15) Confidence 0.78 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.34 Pain Relevance 0.44
Repeated (2-3 weeks) administration of antidepressant drugs increases BDNF gene expression.
Gene_expression (expression) of BDNF associated with antidepressant
16) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0 Pain Relevance 0.36
The results presented here show that BDNF is expressed differentially depending on length of fluoxetine administration, which could contribute in explaining the slow onset of antidepressant activity observed with selective serotonin reuptake inhibitors.
Gene_expression (expressed) of BDNF associated with antidepressant, ssri and fluoxetine
17) Confidence 0.78 Published 2004 Journal Neuroscience Section Abstract Doc Link 15381288 Disease Relevance 0.10 Pain Relevance 0.60
Similarly, the immunohistochemical staining revealed that a significant up-regulation of BDNF expression in the spinal dorsal horn appeared as early as 12 h post-operation in SNL rats, peaked at 24-48 h, declined at 3 days and disappeared at 14 days after SNL.
Gene_expression (expression) of BDNF in dorsal horn associated with spinal dorsal horn
18) Confidence 0.78 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.26 Pain Relevance 0.60
The maximal enhancement of BDNF expression occurred in early stage (24-48 h) after nerve injury, while the peak of NMDA-2B receptors expression appeared in late stage (3-14 days) post-nerve ligation.
Gene_expression (expression) of BDNF in nerve associated with nervous system injury
19) Confidence 0.78 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.31 Pain Relevance 0.46
As compared with the dynamic changes of 50% PWT in the timeline after nerve injury, the maximal enhancement of BDNF expression closely paralleled the maximal decline in the slope of 50% PWT, while the peak of NMDA-2B receptors expression corresponded with the plateau of the decreased 50% PWT.
Gene_expression (expression) of BDNF in nerve associated with nervous system injury
20) Confidence 0.78 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20079352 Disease Relevance 0.53 Pain Relevance 0.62

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