INT16261

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Context Info
Confidence 0.72
First Reported 1991
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 101
Total Number 119
Disease Relevance 49.41
Pain Relevance 40.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 13
hippocampus 12
neurons 9
neuronal 7
DRG 3
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 534 100.00 Very High Very High Very High
imagery 160 100.00 Very High Very High Very High
Nerve growth factor 82 100.00 Very High Very High Very High
peripheral neuropathy 5 99.86 Very High Very High Very High
Spinal cord 427 99.84 Very High Very High Very High
Locus ceruleus 14 99.84 Very High Very High Very High
antidepressant 280 99.80 Very High Very High Very High
Morphine 54 99.80 Very High Very High Very High
monoamine 29 99.72 Very High Very High Very High
Hippocampus 788 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Congenital Anomalies 15 99.92 Very High Very High Very High
Stress 1144 99.86 Very High Very High Very High
Peripheral Neuropathy 5 99.86 Very High Very High Very High
Hyperoxia 30 99.72 Very High Very High Very High
Disease 508 99.68 Very High Very High Very High
Ganglion Cysts 78 99.68 Very High Very High Very High
Apoptosis 40 99.68 Very High Very High Very High
Depression 254 99.64 Very High Very High Very High
Anxiety Disorder 480 99.60 Very High Very High Very High
Post-traumatic Stress Disorder 144 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF mRNA was detected in 35-40% of DRG neurons (L5) of control rats.
Transcription (detected) of BDNF in neurons associated with dorsal root ganglion
1) Confidence 0.72 Published 1999 Journal Neuroreport Section Abstract Doc Link 10619644 Disease Relevance 0.29 Pain Relevance 0.43
Our results indicated that the spontaneous recovery from the decreased levels of BDNF mRNA and protein 24 h after stress is, at least in part, due to plastic changes in the acetylation status of H3 at the promoters of the BDNF gene.
Transcription (levels) of BDNF associated with stress
2) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.77 Pain Relevance 0.03
In summary, this is the first study to demonstrate in an animal model of PTSD that contextual fear is associated with transcription of the BDNF gene in the hippocampus via changes inhistone acetylation.
Transcription (transcription) of BDNF in hippocampus associated with post-traumatic stress disorder, anxiety disorder and hippocampus
3) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.02 Pain Relevance 0.05
In summary, the present study demonstrates that stress affects transcription of the BDNF gene via histone acetylation and demethylation.
Transcription (transcription) of BDNF associated with stress
4) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.89 Pain Relevance 0
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Transcription (expression) of BDNF in hippocampus associated with convulsion, status epilepticus and hippocampus
5) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.63 Pain Relevance 0.09
With regard to emotional learning, such as fear conditioning (FC), Hall et al.27 reported that BDNF mRNA expression is upregulated in the hippocampal CA1 region 24 h after contextual FC, suggesting that BDNF signaling may contribute to synaptic plasticity in this form of learning.
Transcription (expression) of BDNF associated with anxiety disorder
6) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.94 Pain Relevance 0.08
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Spec (examined) Transcription (expression) of BDNF in hippocampus associated with convulsion, status epilepticus and hippocampus
7) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.60 Pain Relevance 0.22
Taken together with previous studies, our results support that exon IV-containing BDNF transcripts plays a pivotal role in the enhanced expression of total BDNF mRNA during the consolidation of contextual fear.
Transcription (expression) of BDNF associated with anxiety disorder
8) Confidence 0.72 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.44 Pain Relevance 0.11
BDNF ASO and GluR1 ASO are specific for rat BDNF mRNA and GluR1 mRNA respectively [24], [83].
Transcription (mRNA) of BDNF
9) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.03
Although L5SSNL increased significantly (P<0.05) the expression of total BDNF mRNA and exon IIC and IXA transcripts in the contralateral L4/5 DRGs, CFA treatment did not alter the expression of total BDNF mRNA or specific transcripts in the contralateral DRGs.
Transcription (expression) of BDNF mRNA
10) Confidence 0.69 Published 2008 Journal Brain Res. Section Abstract Doc Link 18353280 Disease Relevance 0.48 Pain Relevance 0.43
Peripheral tissue inflammation produced by an intraplantar injection of Freund's adjuvant into the paws significantly increased BDNF mRNA levels in the DRG and many neurons expressing trkA mRNA showed increased expession of BDNF mRNA.
Transcription (expession) of BDNF mRNA in DRG associated with dorsal root ganglion and inflammation
11) Confidence 0.69 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.83 Pain Relevance 0.74
To confirm the interaction of Htt and dynein and extend the analysis to BDNF mRNA, we carried out nick-translation of the BDNF coding sequence DNA in order to detect BDNF mRNA in rat brain sections.
Transcription (detect) of BDNF in brain
12) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
Dendritic translation of BDNF mRNA can regulate morphological changes in spines [12].
Transcription (translation) of BDNF in spines
13) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.57 Pain Relevance 0
We next detected BDNF mRNA in cortical neurons by fluorescent in situ hybridization (FISH) using the BDNF coding sequence as probe (Fig. 1b).
Transcription (detected) of BDNF in neurons
14) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.13 Pain Relevance 0
To extend these findings, the expression of BDNF mRNA was analyzed with Htt and CPEB1, a protein responsible for recognition of cytoplasmic polyadenylation elements (CPEs) and regulating poly (A) length.
Spec (analyzed) Transcription (expression) of BDNF in poly
15) Confidence 0.69 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
In addition, very high levels of BDNF, NT-3, and glial cell line-derived neurotrophic factor mRNAs were present in T and NK cell populations infiltrating the CNS.
Transcription (levels) of BDNF in glial cell
16) Confidence 0.69 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.71 Pain Relevance 0.08
CFA evoked robust decreases in NK-1 receptor and BDNF mRNA levels in the hippocampal formation, contrary to the prominent up-regulation seen in the spinal cord.
Transcription (levels) of BDNF in hippocampal formation associated with spinal cord
17) Confidence 0.68 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.73 Pain Relevance 0.68
BDNF ASO and GluR1 ASO are specific for rat BDNF mRNA and GluR1 mRNA respectively [24], [83].
Transcription (specific) of BDNF ASO
18) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.08
To assess NTs in the NuGr in PN, mRNA expression of BDNF, nerve growth factor (NGF), and NT receptors TrkA, TrkB, and p75 was determined 1 week after ligation of L5 and L6 spinal nerves (SNL).
Spec (determined) Transcription (expression) of BDNF in nerve associated with nerve growth factor and peripheral neuropathy
19) Confidence 0.67 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.47 Pain Relevance 0.57
In our method, FISH detection of BDNF mRNA could be performed with protein detection simultaneously without additional steps.
Transcription (detection) of BDNF
20) Confidence 0.66 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.03

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