INT16262

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.02
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
spinal nerve 2
neocortex 2
bladder 2
dorsal root ganglia 2
bowel 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 36 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Spinal nerve ligature 1 99.88 Very High Very High Very High
bDMF 4 99.80 Very High Very High Very High
Inflammation 3 99.68 Very High Very High Very High
neurotrophin 3 6 97.76 Very High Very High Very High
Peripheral nerve injury 1 97.52 Very High Very High Very High
dorsal root ganglion 12 96.24 Very High Very High Very High
nMDA receptor 1 96.04 Very High Very High Very High
amygdala 1 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.68 Very High Very High Very High
Nervous System Injury 4 97.52 Very High Very High Very High
Ganglion Cysts 12 96.24 Very High Very High Very High
Overactive Bladder 5 95.96 Very High Very High Very High
Neuropathic Pain 1 94.56 High High
Convulsion 10 94.00 High High
Injury 3 89.64 High High
Stress Incontinence 5 87.60 High High
Infection 1 84.64 Quite High
Incontinence 4 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of NGF protein and mRNA in the bladder of PNL rats were significantly increased compared with sham rats.
Positive_regulation (increased) of Transcription (levels) of NGF protein in bladder associated with nerve growth factor
1) Confidence 0.50 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18337317 Disease Relevance 1.36 Pain Relevance 0.42
ELISA analyses showed significant increases in NGF levels in L6-S1 dorsal root ganglia of NGF-treated rats.
Positive_regulation (increases) of Transcription (levels) of NGF in dorsal root ganglia associated with nerve growth factor
2) Confidence 0.47 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17050722 Disease Relevance 0.15 Pain Relevance 1.03
NGF and NGF mRNA levels in the bowel were increased during inflammation.
Positive_regulation (increased) of Transcription (levels) of NGF in bowel associated with inflammation and nerve growth factor
3) Confidence 0.46 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130729 Disease Relevance 0.80 Pain Relevance 0.75
Temporally distinct increases in the expression of mRNAs for NGF and BDNF are also observed across broad fields of neocortex, paleocortex (entorhinal, piriform, and cingulate cortices), and the amygdala.
Positive_regulation (increases) of Transcription (expression) of NGF in neocortex associated with nerve growth factor, amygdala and bdmf
4) Confidence 0.46 Published 1991 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1815605 Disease Relevance 0.66 Pain Relevance 0.84
The data showed that following a spinal nerve ligation, the level of NGF mRNA increased 4 times over the normal level and was maintained at a high level for a period of 3 weeks.
Positive_regulation (increased) of Transcription (level) of NGF in spinal nerve associated with nerve growth factor and spinal nerve ligature
5) Confidence 0.44 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9931485 Disease Relevance 0.69 Pain Relevance 0.71
Treatment with SCLM (50, 100 microg/ml) for 48 h elevated the NGF mRNA expression in PC12 cells.
Positive_regulation (elevated) of Transcription (expression) of NGF associated with nerve growth factor
6) Confidence 0.43 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546221 Disease Relevance 0 Pain Relevance 0.55
Figures 2 A, B show that NGF, NT-3, GDNF and BDNF transcription increased continuously over the 14 day cultivation period upon PMA treatment, while bFGF, CNTF and Creb showed a steady decline, but these changes were compensatory modulated by antidepressant drugs (Figure 2C–F).
Positive_regulation (increased) of Transcription (transcription) of NGF associated with antidepressant
7) Confidence 0.24 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.07 Pain Relevance 0.35
GeneChip analysis revealed that neither estrogen nor contraction alone changed the mRNA expression of substance P, the neurokinin-1 receptor, CGRP, NGF, the P2X3 receptor, GABAA and GABAB, the 5-HT3A and 5-HT3B receptor, N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors, opioid receptors, and opioid-like receptor.
Neg (neither) Positive_regulation (changed) of Transcription (expression) of NGF associated with nmda receptor, opioid receptor, opioid and substance p
8) Confidence 0.19 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16306253 Disease Relevance 0.29 Pain Relevance 0.82

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