INT162624

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 8.28
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
dorsal root 4
nucleus 2
nerve 1
cortex 1
Mag (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 430 99.60 Very High Very High Very High
metalloproteinase 10 99.60 Very High Very High Very High
Sciatic nerve 220 98.58 Very High Very High Very High
Endocannabinoid 32 95.32 Very High Very High Very High
Neuropathic pain 95 94.48 High High
Spinal cord 72 92.64 High High
allodynia 20 92.52 High High
Central nervous system 29 90.00 High High
spinal dorsal horn 15 83.72 Quite High
Cannabinoid receptor 16 81.72 Quite High
Disease Link Frequency Relevance Heat
Injury 108 99.82 Very High Very High Very High
Demyelinating Disease 467 99.60 Very High Very High Very High
Schizophrenia 62 99.28 Very High Very High Very High
Nervous System Injury 115 98.72 Very High Very High Very High
Neuropathic Pain 125 94.48 High High
Targeted Disruption 8 91.28 High High
Central Nervous System Disease 24 90.00 High High
Neuromyelitis Optica 12 78.76 Quite High
Multiple Sclerosis 297 77.60 Quite High
Syndrome 16 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that the sciatic nerve injury caused LPA1 receptor-mediated demyelination and its underlying MAG down-regulation only in the dorsal root, but not spinal nerve or sciatic nerve (Figures 1, 2, 4).
Regulation (regulation) of MAG in dorsal root associated with demyelination, nervous system injury and sciatic nerve
1) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.08 Pain Relevance 0.66
When Lpar1-/- mice were used, down-regulation of MAG was completely abolished in the dorsal root (104.1 ± 10.3%/n = 4), but not in the sciatic nerve (62.2 ± 10.7%/n = 5).
Regulation (regulation) of MAG in dorsal root associated with sciatic nerve
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 0.54 Pain Relevance 0.27
Furthermore, metalloproteinase inhibition did not affect MAG down-regulation in the dorsal root following intrathecally administered LPA [32], which mimics the nerve injury in terms of induction of neuropathic pain and its underlying mechanisms [8].
Neg (not) Regulation (affect) of MAG in dorsal root associated with nervous system injury, neuropathic pain and metalloproteinase
3) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.12 Pain Relevance 0.95
Here, we further observed down-regulation of MAG, which inhibits nerve sprouting through regulation of actin assembly by the Rho-Rho kinase-Lim kinase pathway [24].
Regulation (regulation) of MAG in nerve
4) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.29 Pain Relevance 0.58
Injury-induced MAG down-regulation in the dorsal root was slightly observed at day 1 (91.1 ± 7.1%/n = 3) and day 3 (91.8 ± 6.5%/n = 3) post-injury (Figure 4c).
Regulation (regulation) of MAG in dorsal root associated with injury
5) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 0.63 Pain Relevance 0.28
Olig1 is localized in the nucleus during the development phase and may function as a transcriptional regulator for myelin-specific gene expression such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) [12], [14].
Regulation (regulator) of myelin-associated glycoprotein in nucleus
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 1.28 Pain Relevance 0.57
Specifically, microarray expression studies and single-gene quantitative RT-PCR studies indicate a down-regulation of MAG in at least some schizophrenia cohorts [32], [33] and one preliminary study suggested that levels of RTN4 mRNA are also increased in the cortex of some individuals with chronic schizophrenia [34].
Regulation (regulation) of MAG in cortex associated with schizophrenia
7) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.77 Pain Relevance 0.03
Olig1 is localized in the nucleus during the development phase and may function as a transcriptional regulator for myelin-specific gene expression such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) [12], [14].
Regulation (regulator) of MAG in nucleus
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 1.28 Pain Relevance 0.57
For a fix radiation dose and GMA concentration, grafting yield (ranging from 1 to 100 micromol GMA cm(-2)) depended on the time during which the preirradiated PE and PP films and slabs were immersed in the GMA solution.
Regulation (depended) of GMA
9) Confidence 0.11 Published 2009 Journal Int J Pharm Section Abstract Doc Link 19716868 Disease Relevance 0 Pain Relevance 0.07
One explanation for the unaltered myelin formation despite the altered level of MOG, MAG and MBP might be that the extent of reduction, which is subtle compared with the large reductions observed in the mice without the PGKneo cassette [18], was not enough to induce a significant change in the myelin formation during development.
Regulation (altered) of MAG
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.24 Pain Relevance 0.11
Thus, studying molecular mechanisms that control MAG and N-acylethanolamine metabolism in yeast might unveil new strategies for therapeutic interventions modulating the endocannabinoid system.
Regulation (control) of MAG associated with endocannabinoid
11) Confidence 0.07 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.17
To test whether anabolic reactions affect MAG levels, we tested mutant cells lacking the acyltransferases Lro1p and Dga1p.
Spec (whether) Regulation (affect) of MAG
12) Confidence 0.04 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.06 Pain Relevance 0
Compared to wild-type cells, no significant changes in MAG levels were detected in dga1?
Neg (no) Regulation (changes) of MAG
13) Confidence 0.04 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0
In conclusion, our studies suggest that catabolic and anabolic reactions affect cellular MAG levels.
Regulation (affect) of MAG
14) Confidence 0.04 Published 2010 Journal Biochimica et Biophysica Acta Section Abstract Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox