INT162636

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.73
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PTX3)
Anatomy Link Frequency
coronary artery 3
Blood 1
fat 1
plaque 1
PTX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 100.00 Very High Very High Very High
cytokine 11 100.00 Very High Very High Very High
Angina 36 98.68 Very High Very High Very High
rheumatoid arthritis 1 96.60 Very High Very High Very High
Inflammatory mediators 1 85.32 High High
Inflammatory stimuli 1 84.04 Quite High
Inflammatory marker 26 75.00 Quite High
metalloproteinase 9 72.80 Quite High
depression 1 27.04 Quite Low
ischemia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Hyperlipidemia 11 99.88 Very High Very High Very High
Abdominal Obesity 140 99.66 Very High Very High Very High
Diabetes Mellitus 12 99.50 Very High Very High Very High
Hypertension 11 99.12 Very High Very High Very High
Cv General 3 Under Development 28 98.68 Very High Very High Very High
Stable Angina Pectoris 3 98.04 Very High Very High Very High
Natriuresis 15 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 25 97.56 Very High Very High Very High
Myocardial Infarction 248 97.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, and it has been known to be specifically and abundantly present in cardiac muscle.7-9) It has been shown that, unlike CRP, serum PTX3 is rapidly induced by several inflammatory cytokines and primarily secreted from vascular endothelial cells.17) PTX3 secreted from cardiac vascular endothelial cells in response to several immunological signals18) is elevated not only in coronary artery diseases, but also in heart failure and has been reported to correlate with prognosis in heart failure.11)
Localization (secreted) of PTX3 in coronary artery associated with coronary artery disease, inflammation, myocardial infarction and cytokine
1) Confidence 0.78 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.94 Pain Relevance 0.14
, and it has been known to be specifically and abundantly present in cardiac muscle.7-9) It has been shown that, unlike CRP, serum PTX3 is rapidly induced by several inflammatory cytokines and primarily secreted from vascular endothelial cells.17) PTX3 secreted from cardiac vascular endothelial cells in response to several immunological signals18) is elevated not only in coronary artery diseases, but also in heart failure and has been reported to correlate with prognosis in heart failure.11)
Localization (secreted) of PTX3 in coronary artery associated with coronary artery disease, inflammation, myocardial infarction and cytokine
2) Confidence 0.78 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.90 Pain Relevance 0.14
A study by Inoue et al.26) compared 52 patients with stable angina pectoris (SAP) to 16 patients with UAP and reported that PTX3 was not associated with coronary risk factors including hypertension, diabetes mellitus and hyperlipidemia; the value of PTX3 was significantly higher in the UAP than in the SAP group.
Localization (value) of PTX3 associated with stable angina pectoris, angina, diabetes mellitus, hypertension and hyperlipidemia
3) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933461 Disease Relevance 1.84 Pain Relevance 0.73
In our study, in acute myocardial infarction patients, subcutaneous fat and visceral fat were measured quantitatively by FAT-CT, and it was observed that increases in PTX3 concentration were significantly associated with increases in visceral fat and abdominal fat areas.
Localization (concentration) of PTX3 in fat associated with myocardial infarction
4) Confidence 0.73 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.05 Pain Relevance 0.11
, and it has been known to be specifically and abundantly present in cardiac muscle.7-9) It has been shown that, unlike CRP, serum PTX3 is rapidly induced by several inflammatory cytokines and primarily secreted from vascular endothelial cells.17) PTX3 secreted from cardiac vascular endothelial cells in response to several immunological signals18) is elevated not only in coronary artery diseases, but also in heart failure and has been reported to correlate with prognosis in heart failure.11)
Localization (secreted) of PTX3 in coronary artery associated with coronary artery disease, inflammation, myocardial infarction and cytokine
5) Confidence 0.73 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 0.90 Pain Relevance 0.14
Blood samples were taken on admission for measurement of PTX3, high sensitive C-reactive protein (hsCRP), B-type natriuretic peptide (BNP), and troponin T.
Localization (measurement) of PTX3 in Blood associated with natriuresis
6) Confidence 0.71 Published 2009 Journal Thromb. Haemost. Section Abstract Doc Link 19718477 Disease Relevance 0.92 Pain Relevance 0.25
According to the presence or absence of abdominal obesity, in abdominal obesity patients, serum PTX3 concentration was significantly increased (3.00±2.61 vs. 1.33±0.81, p<0.01) (Fig. 2).
Localization (concentration) of PTX3 associated with abdominal obesity
7) Confidence 0.68 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910286 Disease Relevance 1.22 Pain Relevance 0
Human Pentraxin 3 is an isoform which is secreted exclusively in vascular endothelium and therefore may be more specific to the vascular plaque inflammatory activity [91].
Localization (secreted) of Pentraxin 3 in plaque associated with inflammation
8) Confidence 0.09 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.97 Pain Relevance 0.27

General Comments

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