INT16266

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 80
Total Number 81
Disease Relevance 16.14
Pain Relevance 15.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
neurons 18
amacrine cells 7
nucleus ambiguus 3
dorsal root ganglion 3
spinal cord ventral horn 2
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
Neuropeptide 112 99.88 Very High Very High Very High
Spinal cord 366 99.84 Very High Very High Very High
dorsal root ganglion 279 99.80 Very High Very High Very High
Enkephalin 40 99.76 Very High Very High Very High
Action potential 582 99.60 Very High Very High Very High
medulla 53 99.20 Very High Very High Very High
Nicotine 261 98.70 Very High Very High Very High
Calcitonin gene-related peptide 311 98.28 Very High Very High Very High
intrathecal 54 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 189 99.98 Very High Very High Very High
Targeted Disruption 533 99.96 Very High Very High Very High
Ganglion Cysts 1668 99.86 Very High Very High Very High
Urological Neuroanatomy 96 99.84 Very High Very High Very High
Apoptosis 183 99.82 Very High Very High Very High
Injury 24 99.10 Very High Very High Very High
Stress 57 98.44 Very High Very High Very High
Low Back Pain 63 97.54 Very High Very High Very High
INFLAMMATION 104 94.24 High High
Disease 482 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prominent difference between ChAT+ and ChAT?
Gene_expression (prominent) of ChAT
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Somatic size was similar for ChAT+ and ChAT?
Gene_expression (similar) of ChAT
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
As shown in Figs. 2E and 2F, either ChAT-immunoreactivities in laminae I–III or the ratio of the level in the lamina I–III layer to that in motor neurons was significantly reduced by the AS-ODN, but not by the MS-ODN.
Neg (not) Gene_expression (reduced) of ChAT in lamina
3) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.38 Pain Relevance 0.25
Reduced nociceptive thresholds by ChAT-knock down
Gene_expression (thresholds) of ChAT associated with targeted disruption and nociception
4) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.35 Pain Relevance 0.23
Subthreshold characteristics of ChAT+ and ChAT?
Gene_expression (characteristics) of ChAT
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
During action potential trains at 10 Hz, the normalized action potential amplitude (normalized to the first action potential) was 0.85±0.03 for ChAT+ neurons and 0.92±0.02 for ChAT?
Gene_expression (neurons) of ChAT in neurons associated with action potential
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.15
neurons (ChAT+ neurons were 35.3×15.8 µm; ChAT?
Gene_expression (15.8) of ChAT in neurons
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
neurons was the lower spiking frequency of ChAT+ neurons during depolarizing current injections (figure 4C,D).
Gene_expression (neurons) of ChAT in neurons
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Membrane sag, which often indicates the presence of h-type non-specific cation conductance [31], [32], was negligible in ChAT+ neurons and significantly larger, but still small in ChAT?
Gene_expression (neurons) of ChAT in neurons
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Somatic size was similar for ChAT+ and ChAT?
Gene_expression (similar) of ChAT
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Membrane sag, which often indicates the presence of h-type non-specific cation conductance [31], [32], was negligible in ChAT+ neurons and significantly larger, but still small in ChAT?
Gene_expression (negligible) of ChAT in neurons
11) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
A prominent difference between ChAT+ and ChAT?
Gene_expression (prominent) of ChAT
12) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Of 50 recordings (from 29 mice) we identified 9 ChAT+ neurons and 30 ChAT?
Gene_expression (neurons) of ChAT in neurons
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Subthreshold characteristics of ChAT+ and ChAT?
Gene_expression (characteristics) of ChAT
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
The difference in spike rate was sufficiently pronounced that the neurons could readily be identified as ChAT+ or ChAT?
Gene_expression (identified) of ChAT in neurons
15) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.12
Neurons with somatic intensities between 25 and 75% of ChAT+ neurons were not classified and were excluded from further analysis.
Gene_expression (neurons) of ChAT in neurons
16) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Both ChAT+ and ChAT?
Gene_expression (Both) of ChAT
17) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.13
neurons (ChAT+ neurons were 35.3×15.8 µm; ChAT?
Gene_expression (neurons) of ChAT in neurons
18) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
With increasing current injections the spiking rates of ChAT+ neurons increased to a plateau frequency of ?
Gene_expression (neurons) of ChAT in neurons
19) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.05
Both ChAT+ and ChAT?
Gene_expression (Both) of ChAT
20) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0.13

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