INT162666

Context Info Confidence 0.67 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 5.66 Pain Relevance 1.73

Anatomy Link Frequency intestine 1 ST3 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 98.92 Lasting pain 23 98.12 Acupuncture 104 97.44 Pain 10 97.44 Chronic low back pain 7 95.92 Analgesic 4 94.64 metalloproteinase 10 94.48 rheumatoid arthritis 4 92.56 headache 8 86.96 Fibrositis 2 84.40

Disease Link Frequency Relevance Heat Breast Cancer 2 100.00 Cancer 48 99.56 Dermatofibroma 20 99.36 Pathologic Processes 2 99.20 Wound Healing 4 99.12 INFLAMMATION 7 98.82 Pain 29 98.12 Atherosclerosis 2 97.12 Low Back Pain 9 95.28 Rheumatoid Arthritis 5 92.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ST3 is expressed in the majority of cases of DF, whereas DFSPs are only rarely ST3 positive.

Gene_expression (expressed) of ST3 associated with dermatofibroma

1) Confidence 0.67 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2892497 Disease Relevance 1.22 Pain Relevance 0.05

OBJECTIVE: The objective of this study was to modify the release characteristics of lornoxicam, a highly potent nonsteroidal anti-inflammatory drug, by preparing compression-coated tablets (CCTs) that provide complete drug release that starts in the stomach to rapidly alleviate the painful symptoms and continues in the intestine to maintain prolonged analgesic effect as well as meets the reported sustained release specifications.

Gene_expression (provide) of CCTs in intestine associated with pain, inflammation, analgesic and cinod

2) Confidence 0.58 Published 2010 Journal Drug Dev Ind Pharm Section Abstract Doc Link 19722915 Disease Relevance 0.10 Pain Relevance 0.29

ST3 is expressed in the majority of cases of DF, whereas DFSPs are only rarely ST3 positive.

Gene_expression (positive) of ST3 associated with dermatofibroma

3) Confidence 0.50 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2892497 Disease Relevance 1.24 Pain Relevance 0.05

MMP11 or stromelysin-3 (ST3), first isolated as a breast cancer-associated protease, is not expressed in the majority of normal adult organs but is expressed during a number of pathological processes, including wound healing and atherosclerotic lesions [38,39].

Neg (not) Gene_expression (expressed) of ST3 associated with pathologic processes, atherosclerosis, wound healing and breast cancer

4) Confidence 0.30 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.99 Pain Relevance 0.04

MMP11 or stromelysin-3 (ST3), first isolated as a breast cancer-associated protease, is not expressed in the majority of normal adult organs but is expressed during a number of pathological processes, including wound healing and atherosclerotic lesions [38,39].

Gene_expression (expressed) of ST3 associated with pathologic processes, atherosclerosis, wound healing and breast cancer

5) Confidence 0.23 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 1.02 Pain Relevance 0.05

A summary of these CCTs is shown in Table 2.

Gene_expression (summary) of CCTs

6) Confidence 0.14 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176146 Disease Relevance 1.09 Pain Relevance 1.26

General Comments

This test has worked.