INT162669

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.77
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkag1) nucleus (Prkag1) protein complex (Prkag1)
response to stress (Prkag1)
Anatomy Link Frequency
aorta 1
liver 1
Prkag1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 40 99.10 Very High Very High Very High
qutenza 16 98.80 Very High Very High Very High
adenocard 1 91.40 High High
Inflammatory response 13 82.20 Quite High
Multiple sclerosis 1 78.64 Quite High
ischemia 3 70.32 Quite High
COX-2 inhibitor 4 66.08 Quite High
COX2 4 64.08 Quite High
cytokine 46 59.32 Quite High
Inflammatory mediators 11 58.88 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 1 100.00 Very High Very High Very High
Breast Cancer 4 99.36 Very High Very High Very High
INFLAMMATION 65 99.10 Very High Very High Very High
Apoptosis 7 90.80 High High
Body Weight 20 90.56 High High
Increased Venous Pressure Under Development 2 82.96 Quite High
Drug Induced Neurotoxicity 4 81.04 Quite High
Demyelinating Disease 1 78.64 Quite High
Multiple Sclerosis 1 76.88 Quite High
Vasculitis 6 76.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that genistein in combination with capsaicin exerts anti-inflammatory and anticarcinogenic properties through the modulation of AMPK and COX-2 and possibly various mitogen-activated protein kinases synergistically or nonsynergistically.
Spec (possibly) Regulation (modulation) of AMPK associated with inflammation and qutenza
1) Confidence 0.09 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19723084 Disease Relevance 0.74 Pain Relevance 0.85
The abilities of genistein alone or in combination with capsaicin in inhibiting breast cancer cell proliferation through the modulation of AMPK and COX-2 were tested.
Regulation (modulation) of AMPK associated with qutenza and breast cancer
2) Confidence 0.09 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19723084 Disease Relevance 0.80 Pain Relevance 0.90
AMPK is known to regulate glucose transport [47] and its metabolism [48], lower blood pressure, boost liver insulin action [49], ameliorate insulin resistance induced by free fatty acids [18], and regulate protein synthesis [50] and forkhead transcription factor FKHR (FOXO1a) [51].
Regulation (resistance) of AMPK in liver associated with insulin resistance
3) Confidence 0.04 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.31 Pain Relevance 0.35
VSMCs and rabbit aorta expressed the upstream AMPK kinase LKB1 protein, and rottlerin-induced AMPK activation was decreased in VSMCs by overexpression of dominant negative LKB1, suggesting that LKB1 is involved in the upstream regulation of AMPK stimulated by rottlerin.21) These data therefore imply that LKB1 mediates rottlerin-induced activation of AMPK in vascular cells and tissues.
Regulation (regulation) of AMPK in aorta
4) Confidence 0.02 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.69 Pain Relevance 0
Recently Ramadori et. al. reported that chronic central infusion of resveratrol did not alter food intake or AMPK activity [43].
Neg (not) Regulation (alter) of AMPK
5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0

General Comments

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