INT162706

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Emp1) molecular_function (Emp1) biological_process (Emp1)
Anatomy Link Frequency
dorsal 1
arterioles 1
Emp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 41 99.64 Very High Very High Very High
ischemia 20 99.16 Very High Very High Very High
Dynorphin 1 96.24 Very High Very High Very High
Kinase C 1 67.24 Quite High
Pain 3 50.00 Quite Low
isoflurane 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain management 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Ischemia 15 99.64 Very High Very High Very High
Shock 1 99.02 Very High Very High Very High
Reperfusion Injury 3 98.76 Very High Very High Very High
Injury 13 90.58 High High
Frailty 6 74.08 Quite High
Death 2 73.00 Quite High
Pain 4 50.00 Quite Low
Burns 2 50.00 Quite Low
Cv Unclassified Under Development 4 40.84 Quite Low
Pressure And Volume Under Development 1 35.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to pharmacology of TMP and studies for effects of TMP on cerebral ischemic injury, antiplatelet activation and aggregation, dilating arterioles to improve microcirculation [17,18], scavenging free radicals, increasing the activity of SOD and decreasing lipid peroxidation [10], inhibiting calcium overload [9], reducing the production of nitric oxide and dynorphin A1-13 in ischemic tissue [19,20], decreasing the protein expression of c-fos and increasing the protein expression of bcl-2 and heat shock protein 70(HSP 70) [21,22]may be mechanisms for protection of TMP against spinal cord ischemia /reperfusion injury.
Gene_expression (protection) of TMP in arterioles associated with reperfusion injury, dynorphin, ischemia, shock, injury and spinal cord
1) Confidence 0.49 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.91 Pain Relevance 0.43
After treatment with TMP, P2X3-receptor expression of the nerve terminal in the first- and second-degree dorsal burns of the TMP treatment group was significantly decreased.
Gene_expression (expression) of TMP in dorsal
2) Confidence 0.24 Published 2010 Journal Burns Section Body Doc Link 19726132 Disease Relevance 0 Pain Relevance 0

General Comments

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