INT162721

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Context Info
Confidence 0.12
First Reported 2009
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.17
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
Anatomy Link Frequency
cleavage 2
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 1 91.36 High High
amygdala 5 90.68 High High
anesthesia 1 78.40 Quite High
ischemia 8 76.36 Quite High
Limbic system 3 75.00 Quite High
cytokine 3 41.00 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 130 98.44 Very High Very High Very High
Apoptosis 143 96.40 Very High Very High Very High
Colon Cancer 44 95.20 Very High Very High Very High
Stress 30 80.56 Quite High
Coronary Artery Disease 2 76.36 Quite High
Necrosis 8 75.00 Quite High
Myocardial Infarction 5 75.00 Quite High
Acute Monocytic Leukemia 1 73.44 Quite High
Death 49 68.56 Quite High
Injury 9 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PEG sTNFRI inhibited caspase-8 activation in the DG.
Negative_regulation (inhibited) of Positive_regulation (activation) of caspase-8
1) Confidence 0.12 Published 2009 Journal Apoptosis Section Abstract Doc Link 19728097 Disease Relevance 0.71 Pain Relevance 0.52
Like THP1 macrophages, normal peripheral blood monocytes restored the MMP and prevented activation of caspase 8 and cleavage of PARP in TRAIL-treated tumor cells (data not shown, Figure S2), which is consistent with the ability of colon cancer cells to induce IL-1?
Negative_regulation (prevented) of Positive_regulation (activation) of caspase 8 in cleavage associated with cancer and colon cancer
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.07 Pain Relevance 0
Our findings reveal that although OGE pretreatment does not significantly decrease the activation of H2O2-induced caspase-8, it does diminish the formation of tBid.
Neg (not) Negative_regulation (decrease) of Positive_regulation (activation) of caspase-8
3) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.44 Pain Relevance 0
Our findings reveal that although OGE pretreatment does not significantly decrease the activation of H2O2-induced caspase-8, it does diminish the formation of tBid.
Neg (not) Negative_regulation (decrease) of Positive_regulation (induced) of caspase-8
4) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.44 Pain Relevance 0
Although many polyphenolic acids such as caffeic acid [46] and epigallocatechin gallate [47] have been reported to inhibit the activation of caspase-8, the mechanisms behind OGE's protection of H9c2 cells from H2O2-induced damage need further investigation.
Negative_regulation (inhibit) of Positive_regulation (activation) of caspase-8
5) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.51 Pain Relevance 0

General Comments

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