INT16277

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 11.31
Pain Relevance 4.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGA)
Anatomy Link Frequency
neuron 6
plasma 2
bowel 2
cleavage 1
sympathetic 1
CHGA (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 5 100.00 Very High Very High Very High
Serotonin 13 99.92 Very High Very High Very High
Catecholamine 43 99.88 Very High Very High Very High
Neuropeptide 4 99.48 Very High Very High Very High
spastic colon 316 99.32 Very High Very High Very High
agonist 6 99.12 Very High Very High Very High
qutenza 5 99.02 Very High Very High Very High
Somatostatin 13 98.40 Very High Very High Very High
Dopamine 8 92.52 High High
Clonidine 3 87.00 High High
Disease Link Frequency Relevance Heat
Stress 76 100.00 Very High Very High Very High
Cancer 91 99.76 Very High Very High Very High
Pheochromocytoma 22 99.74 Very High Very High Very High
Paraganglioma 44 99.68 Very High Very High Very High
Hypertension 9 99.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

333 99.32 Very High Very High Very High
Functional Bowel Disorder 16 99.22 Very High Very High Very High
Carcinoma 8 98.52 Very High Very High Very High
Renal Failure 4 97.52 Very High Very High Very High
Syndrome 13 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chromogranin A is present in both adrenal medullary chromaffin granules and sympathetic nerve large dense core catecholamine storage vesicles (LDVs), yet selective stimulation of sympathetic axons provokes only minor changes in chromogranin A in the circulation.
Regulation (changes) of chromogranin A in sympathetic associated with catecholamine
1) Confidence 0.44 Published 1991 Journal Brain Res. Section Abstract Doc Link 1817725 Disease Relevance 0 Pain Relevance 0.20
Immunohistochemistry showed positivity for synaptophysin, neuron specific enolase, chromogranin and cytokeratin.
Regulation (positivity) of chromogranin in neuron
2) Confidence 0.44 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092435 Disease Relevance 1.17 Pain Relevance 0.08
These cells are immunopositive for neuroendocrine markers including synaptophysin and chromogranin A and for several neuropeptides.
Regulation (immunopositive) of chromogranin A associated with neuropeptide
3) Confidence 0.44 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 1.15 Pain Relevance 0.20
Histological section of the tumour tissue revealed paraganglioma, which stained positive for chromogranin and neuron-specific enolase.
Regulation (positive) of chromogranin in neuron associated with cancer and paraganglioma
4) Confidence 0.44 Published 2005 Journal Ann. Clin. Biochem. Section Abstract Doc Link 15802039 Disease Relevance 0.64 Pain Relevance 0.38
We investigated the effects of a novel chromogranin A catecholamine release-inhibitory fragment, catestatin (chromogranin A344-364), on agonist-induced desensitization of catecholamine release from pheochromocytoma cells.
Regulation (effects) of chromogranin associated with catecholamine, agonist and pheochromocytoma
5) Confidence 0.44 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 9915830 Disease Relevance 0.09 Pain Relevance 0.51
Microscopically, immunostaining was positive for chromogranin and neuron-specific enolase.
Regulation (positive) of chromogranin in neuron
6) Confidence 0.44 Published 2010 Journal BMC Urol Section Body Doc Link PMC3016340 Disease Relevance 1.43 Pain Relevance 0.07
In addition to positive carcinoembryonic antigen and cytokeratin, the argyrophilic cancer cells were immunoreactive for neuron-specific enolase, chromogranin A, serotonin, neuropeptide Y, glicentin, somatostatin, neurotensin and calcitonin.
Regulation (immunoreactive) of chromogranin A in neuron associated with cancer, somatostatin, neuropeptide and serotonin
7) Confidence 0.44 Published 1991 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 1942551 Disease Relevance 1.18 Pain Relevance 0.22
We conclude that 1) chromogranin A emerges along with catecholamines from pheochromocytoma chromaffin granules; 2) plasma chromogranin A is a sensitive and specific diagnostic tool in evaluation of actual or suspected pheochromocytoma; 3) plasma chromogranin A predicts pheochromocytoma tumor size and overall catecholamine production; and 4) drugs commonly employed in the diagnosis or treatment of pheochromocytoma have little effect on plasma chromogranin A level, preserving the usefulness of chromogranin A in evaluating pheochromocytoma.
Neg (little) Regulation (effect) of chromogranin A in plasma associated with cancer, catecholamine and pheochromocytoma
8) Confidence 0.44 Published 1991 Journal Medicine (Baltimore) Section Abstract Doc Link 1988765 Disease Relevance 1.23 Pain Relevance 0.24
Cerebrospinal fluid chromogranin A was not changed (P > 0.1) in essential hypertension (84.2 +/- 14.0 ng/ml) or renal failure (72.2 +/- 13.4 ng/ml), despite a marked (7.1-fold; P < 0.001) increase in plasma chromogranin A in renal failure, and a modest (1.5-fold; P = 0.004) increase in plasma chromogranin A in essential hypertension.
Neg (not) Regulation (changed) of chromogranin A in plasma associated with renal failure and hypertension
9) Confidence 0.44 Published 1993 Journal Neuroscience Section Abstract Doc Link 7904334 Disease Relevance 0.72 Pain Relevance 0.17
These findings demonstrate that production of catestatin involves cleavage of CgA at paired basic and monobasic residues, necessary steps for catestatin peptide regulation of nicotinic cholinergic-induced catecholamine release.
Regulation (cleavage) of CgA in cleavage associated with catecholamine
10) Confidence 0.26 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.05
Psychophysiological processing has been reported to play a crucial role in irritable bowel syndrome (IBS) but there has been no report on modulation of the stress marker chromogranin A (CgA) resulting from muscle stretching.
Regulation (modulation) of chromogranin A in bowel associated with stress and spastic colon
11) Confidence 0.26 Published 2008 Journal Biopsychosoc Med Section Abstract Doc Link PMC2588633 Disease Relevance 0.45 Pain Relevance 0.37
Changes in revised salivary CgA levels between before and after stretching sessions for each group were analyzed statistically by related-measures 3-factor ANOVA, followed by Bonferroni protected least significant difference for multiple comparisons; values of p < 0.05 were considered significant.
Spec (analyzed) Regulation (Changes) of CgA
12) Confidence 0.26 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.07 Pain Relevance 0.10
Lastly, we could not analyze the effect of lifestyle and medical history on CgA in this study.
Spec (analyze) Regulation (effect) of CgA
13) Confidence 0.26 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.27 Pain Relevance 0.68
Psychophysiological processing has been reported to play a crucial role in irritable bowel syndrome (IBS) but there has been no report on modulation of the stress marker chromogranin A (CgA) resulting from muscle stretching.
Regulation (modulation) of CgA in bowel associated with stress and spastic colon
14) Confidence 0.26 Published 2008 Journal Biopsychosoc Med Section Abstract Doc Link PMC2588633 Disease Relevance 0.45 Pain Relevance 0.37
The serum values of CgA, CgB, pancreastatin (Pst), NSE, and prostate-specific antigen (PSA) were determined from each sample.
Regulation (values) of CgA
15) Confidence 0.26 Published 1997 Journal Prostate Section Abstract Doc Link 9140124 Disease Relevance 0.56 Pain Relevance 0.17
Preoperative serum values of chromogranin A (CgA), chromogranin B (CgB), pancreastatin (Pst), neuron-specific enolase (NSE), and prostatic specific antigen (PSA) were determined in 22 patients.
Regulation (values) of CgA in neuron
16) Confidence 0.26 Published 1997 Journal Prostate Section Abstract Doc Link 9018329 Disease Relevance 0.35 Pain Relevance 0.15
Capsaicin was given subcutaneously to guinea pigs and the effect on substance P-immunoreactive (SP-I) fibers in the celiac/superior mesenteric and inferior mesenteric ganglia was observed at 2 day and 8-10 day intervals.
Regulation (effect) of SP-I in inferior associated with qutenza and substance p
17) Confidence 0.24 Published 1983 Journal Peptides Section Abstract Doc Link 6197703 Disease Relevance 0 Pain Relevance 0.42
Formalin-fixed and paraffin-embedded pancreatic tissue was used as a positive control for synaptophysin, chromogranin, and neuron-specific enolase (NSE); hepatic tissue for alpha-fetoprotein (AFP) and Hep-Par1; and epidermis for cytokeratin.
Regulation (control) of chromogranin in neuron
18) Confidence 0.12 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950516 Disease Relevance 0.49 Pain Relevance 0.07

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