INT162781

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.91
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b)
proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)
Tnfrsf11b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 92.08 High High
anesthesia 3 5.00 Very Low Very Low Very Low
complementary and alternative medicine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 99.12 Very High Very High Very High
Hypercalcemia 19 98.92 Very High Very High Very High
Bone Cancer 13 97.48 Very High Very High Very High
Pain 1 92.08 High High
Osteoporosis 75 89.44 High High
Apoptosis 2 64.56 Quite High
Overweight 2 50.00 Quite Low
Postmenopausal Osteoporosis 6 42.80 Quite Low
Endometriosis (extended) 9 32.48 Quite Low
Body Weight 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our study is the first to report that HEP extract stimulated the expression of OPG mRNA but suppressed the expression of RANKL mRNA in the UMR 106 cell line, resulting in a dose-dependent increase in the OPG/RANKL ratio.
Positive_regulation (increase) of OPG
1) Confidence 0.27 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.25 Pain Relevance 0
Apart from the expected significant increase in serum OPG with age and the higher levels in females [22], OPG or RANKL were not significantly associated with any of the other variables included in the study.
Positive_regulation (increase) of serum OPG
2) Confidence 0.27 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.12 Pain Relevance 0
As shown in Fig. 5C, the OPG/RANKL ratio in UMR 106 cells increased when they were treated with HEP extract at 100 ?
Positive_regulation (increased) of OPG
3) Confidence 0.18 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.34 Pain Relevance 0
B ligand (RANKL) mRNA expression, resulting in a dose-dependent increase in OPG/RANKL mRNA ratio (P < 0.01 versus vehicle-treated).
Positive_regulation (increase) of OPG
4) Confidence 0.09 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC1193542 Disease Relevance 0.22 Pain Relevance 0
Bone tumors are related to the existence of a vicious cycle between bone resorption and tumor proliferation in which the molecular triad osteoprotegerin (OPG)/receptor activator of NF-kappaB (RANK)/RANK ligand (RANKL) plays a pivotal role.
Positive_regulation (activator) of osteoprotegerin associated with cancer, hypercalcemia and bone cancer
5) Confidence 0.02 Published 2010 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19733222 Disease Relevance 0.98 Pain Relevance 0.09

General Comments

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