INT162782

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.09
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b)
proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)
Tnfrsf11b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 4 96.88 Very High Very High Very High
Pain 1 94.24 High High
Angina 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
complementary and alternative medicine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 36 99.32 Very High Very High Very High
Bone Cancer 7 98.64 Very High Very High Very High
Cancer 4 97.48 Very High Very High Very High
Rheumatoid Arthritis 4 96.88 Very High Very High Very High
Pain 1 94.24 High High
Disease 9 92.16 High High
Hypercalcemia 26 88.92 High High
Overweight 8 75.00 Quite High
Apoptosis 2 66.84 Quite High
Obesity 4 53.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that HEP extract might inhibit osteoclastogenesis via the modulation of the OPG/RANKL system in osteoblastic cells.
Spec (might) Regulation (modulation) of OPG associated with osteoporosis
1) Confidence 0.24 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.32 Pain Relevance 0
After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL.


Regulation (change) of serum OPG
2) Confidence 0.16 Published 2010 Journal Nutr J Section Abstract Doc Link PMC2818614 Disease Relevance 0.07 Pain Relevance 0
In the present study we found no significant associations for serum 25(OH)D with BMD, serum OPG or serum RANKL at baseline after adjustment for confounders, nor did vitamin D supplementation for one year differ form placebo regarding change in BMD, serum OPG or serum RANKL.
Regulation (change) of serum OPG
3) Confidence 0.16 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.08 Pain Relevance 0
No effect on OPG by bisphosphonate therapy has been reported in subjects with osteoporosis or rheumatoid arthritis [30,31], whereas a decrease in OPG after bisphosphonates has been found in subjects with Paget's disease [30].
Neg (No) Regulation (effect) of OPG associated with rheumatoid arthritis, osteoporosis and disease
4) Confidence 0.16 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.29 Pain Relevance 0.05
Thus, the effect of vitamin D on BMD, serum OPG and RANKL were only secondary endpoints, most of the included subjects were not vitamin D deficient, and serum 1,25(OH)2D was not measured.
Regulation (effect) of serum OPG
5) Confidence 0.07 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.35 Pain Relevance 0.04
Regulation of osteoprotegerin pro- or anti-tumoral activity by bone tumor microenvironment.
Regulation (Regulation) of osteoprotegerin associated with bone cancer
6) Confidence 0.03 Published 2010 Journal Biochim. Biophys. Acta Section Title Doc Link 19733222 Disease Relevance 0.98 Pain Relevance 0.09

General Comments

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