INT162792

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 6.11
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD1) signal transduction (NOD1) plasma membrane (NOD1)
intracellular (NOD1) cytoplasm (NOD1)
Anatomy Link Frequency
T cells 4
dental pulp 2
eye 1
epithelial cells 1
fibroblasts 1
NOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
Inflammatory mediators 21 97.64 Very High Very High Very High
rheumatoid arthritis 1 97.36 Very High Very High Very High
Inflammation 166 95.36 Very High Very High Very High
pulpitis 6 93.72 High High
Inflammatory response 45 89.64 High High
cytokine 183 88.24 High High
chemokine 3 87.36 High High
Arthritis 8 81.12 Quite High
agonist 45 77.00 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 2 99.74 Very High Very High Very High
Death 13 98.80 Very High Very High Very High
INFLAMMATION 223 97.64 Very High Very High Very High
Rheumatoid Arthritis 1 97.36 Very High Very High Very High
Synovitis 1 96.24 Very High Very High Very High
Disease 92 94.96 High High
Malignant Neoplastic Disease 13 94.84 High High
Pulpitis 6 93.72 High High
Skin Cancer 12 92.36 High High
Reprotox - General 1 13 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that Nod1, Nod2, and NLRX1 were expressed at comparable levels in both cell types with an apparently uniform expression level in the primary corneal cell samples.
Gene_expression (expressed) of Nod1
1) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.03
Surprisingly, after 24 h, although Nod1 and Nod2 expression increased compared to the 6 h samples, all the studied Nod expression remained low compared to the non-exposed samples (Figure 6B).
Gene_expression (expression) of Nod1
2) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.10
Effect of UV-B irradiation on the expression of Nod subtypes in HCE-T cells
Gene_expression (expression) of Nod in T cells
3) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
On the other hand, expression pattern of Nod family members appeared to be similar in the two cell types.
Gene_expression (expression) of Nod
4) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.77 Pain Relevance 0
Expression of Nod subfamily members in immortalized and primary corneal epithelial cells
Gene_expression (Expression) of Nod in corneal epithelial cells
5) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
We found clear expressions of TLR2, NOD1, and NOD2 and a faint expression of TLR4 in human dental pulp fibroblasts (HDPF) by RT-PCR and flow cytometry.
Spec (clear) Gene_expression (expressions) of NOD1 in dental pulp
6) Confidence 0.71 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.45
We also wanted to know how the expression of the Nod subfamily, the other sensor subfamily of the NLR family, would be influenced by the UV-B radiation at early (6 h) and late (24 h) time points.
Gene_expression (expression) of Nod
7) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.03
Surprisingly, after 24 h, although Nod1 and Nod2 expression increased compared to the 6 h samples, all the studied Nod expression remained low compared to the non-exposed samples (Figure 6B).
Gene_expression (expression) of Nod
8) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.11
B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?
Gene_expression (/) of Nod1
9) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.26
Effect of UV-B irradiation on the expression of Nod subtypes in HCE-T cells
Gene_expression (expression) of Nod in T cells
10) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
The time-dependent appearance of pIkB after PGN-ECndss treatment implies the presence of functional Nod1 and/or Nod2 proteins in HCE-T cells that are able to recognize the peptidoglycan ligand and trigger the NF?
Gene_expression (presence) of Nod1 in T cells
11) Confidence 0.62 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.04
Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.
Gene_expression (Roles) of NOD1 in fibroblasts associated with cox2
12) Confidence 0.61 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55
While the different expression levels of inflammasome components in primary corneal cells and HCE-T cells suggest that the immortalized cells may behave differently to Nalp ligands, the similar expression pattern of Nod sensors in the two cell types and the functional Nod1/Nod2-dependent NF?
Gene_expression (expression) of Nod in T cells
13) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.36 Pain Relevance 0.14
We found that Nod1, Nod2, and NLRX1 were expressed at comparable levels in both cell types with an apparently uniform expression level in the primary corneal cell samples.
Gene_expression (expression) of Nod1
14) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.03
We found clear expressions of TLR2, NOD1, and NOD2 and a faint expression of TLR4 in human dental pulp fibroblasts (HDPF) by RT-PCR and flow cytometry.
Gene_expression (expression) of NOD1 in dental pulp
15) Confidence 0.55 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.45
Our data support a central role for the Nod/Uv in this process and predict that Nod/Uv lesions would interfere with tVOR plasticity.


Gene_expression (lesions) of Nod/Uv
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981566 Disease Relevance 0 Pain Relevance 0
Nod/Uv lesions reduce sustained eye velocity during steps of interaural translation
Gene_expression (lesions) of Nod/Uv in eye
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981566 Disease Relevance 0 Pain Relevance 0
There was no statistically significant pair-wise difference between the three groups in willingness to participate after Card1 and Card 2 or in the likelihood of changing decision (each P > 0.05).
Gene_expression (participate) of Card1
18) Confidence 0.18 Published 2010 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2949696 Disease Relevance 0.16 Pain Relevance 0.04
Genetic (NOD2, NOD1, TLR4, CARD8) and new serologic markers (ASCA, ACMA, ALCA, ACCA, ASigmaMA, OmpC, CBir1, I2) were analyzed in all of the subjects.
Spec (analyzed) Gene_expression (Genetic) of NOD1
19) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.19 Pain Relevance 0.04
It is stimulated by Mycobacterium tuberculosis [22] and it synergizes with NOD1 and NOD2 ligands to stimulate IL-1?
Gene_expression (synergizes) of NOD1 associated with mycobacterial infection
20) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0.94 Pain Relevance 0.41

General Comments

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