INT162801

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.69
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CALR) Golgi apparatus (CALR) endoplasmic reticulum (CALR)
intracellular (CALR) DNA binding (CALR) cytoplasm (CALR)
Anatomy Link Frequency
kidney 1
CALR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 100.00 Very High Very High Very High
imagery 4 96.96 Very High Very High Very High
cINOD 1 92.72 High High
methotrexate 2 89.04 High High
rheumatoid arthritis 5 87.88 High High
Arthritis 3 83.92 Quite High
Pain 19 76.56 Quite High
chemokine 3 72.84 Quite High
depression 4 50.88 Quite High
cytokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 71 100.00 Very High Very High Very High
INFLAMMATION 26 100.00 Very High Very High Very High
Stress 30 99.58 Very High Very High Very High
Disease 172 98.56 Very High Very High Very High
Coccidioides Infection 3 98.34 Very High Very High Very High
Viral Infection 5 97.82 Very High Very High Very High
Muscular Atrophy 1 97.60 Very High Very High Very High
Treponema Pallidum Infection 4 97.38 Very High Very High Very High
Death 12 97.28 Very High Very High Very High
Zoonoses 4 97.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laboratory tests presented normal acute phase reactants of inflammation as well as the rheumatoid factor, CK, and negative results for antinuclear, anti-DNA, anti-SSA/Ro, and anti-CCP (ELISA) antibodies.
Localization (presented) of SSA associated with inflammation
1) Confidence 0.73 Published 2009 Journal J Clin Rheumatol Section Abstract Doc Link 19734739 Disease Relevance 1.41 Pain Relevance 0.51
Alternatively, increased ER stress (CRT levels) and co-localization of CRT and COMP were greatly diminished in cells overexpressing MT-COMP in the presence of shRNA 3B (Fig. 3I–L).
Localization (localization) of CRT associated with stress
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.71 Pain Relevance 0
Additionally, CRT and MT-COMP co-localize to the ER, demonstrating intracellular retention (Fig. 3H).
Localization (localize) of CRT
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.64 Pain Relevance 0
Might neoadjuvant CRT improve resectability and survival?
Localization (resectability) of CRT
4) Confidence 0.22 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939765 Disease Relevance 0.79 Pain Relevance 0
However, as shown in Table 4, there are more than a dozen important NTDs, including the protozoan infections, amebiasis and toxoplasmosis; bacterial infections such as Salmonella infections (both typhoid fever and non-typhoidal salmonellosis), the tick-borne zoonoses, and yaws; and viral infections such as Rift Valley fever, for which there is insufficient information available in order to estimate their prevalence in SSA.
Localization (prevalence) of SSA associated with salmonella infection, disease, zoonoses, protozoal infection, amebiasis, treponema pallidum infection, viral infection, bacterial infection, coccidioides infection and toxoplasmosis
5) Confidence 0.11 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 2.86 Pain Relevance 0
Two molecules are suggested to be key parameters in this process; calreticulin (CRT) [10], which is exposed on the cell surface of tumour cells, and high mobility group box 1 (HMGB-1), which is secreted by dying tumor cells.
Localization (secreted) of calreticulin associated with cancer
6) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.81 Pain Relevance 0.07
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Localization (creatinine) of Crt in kidney
7) Confidence 0.07 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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