INT162823

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.69
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
blood 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 100.00 Very High Very High Very High
cytokine 32 100.00 Very High Very High Very High
Analgesic 3 95.32 Very High Very High Very High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 384 100.00 Very High Very High Very High
Infection 276 100.00 Very High Very High Very High
INFLAMMATION 38 100.00 Very High Very High Very High
Pressure And Volume Under Development 118 98.70 Very High Very High Very High
Hypertension 3 98.52 Very High Very High Very High
Viral Infection 8 29.36 Quite Low
Ulcers 2 23.88 Low Low
Sprains And Strains 10 22.56 Low Low
Atherosclerosis 58 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.
Regulation (regulation) of Gene_expression (expression) of renin associated with hypertension
1) Confidence 0.62 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0.09 Pain Relevance 0.08
The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.
Regulation (regulation) of Gene_expression (expression) of renin-angiotensin-aldosterone-system associated with hypertension
2) Confidence 0.45 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0.10 Pain Relevance 0.08
Up-regulation in the expression of renin gene by the influence of aluminium.
Regulation (regulation) of Gene_expression (expression) of renin
3) Confidence 0.45 Published 2009 Journal J. Inorg. Biochem. Section Title Doc Link 19735944 Disease Relevance 0 Pain Relevance 0.10
To examine the effect of MCMV infection on renin expression, the cells were infected with MCMV and then allowed to grow in chambered slides for 5 days.
Regulation (effect) of Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
4) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 0.46 Pain Relevance 0
These results support that CMV infection of blood vessel cells and expression of viral RNA and DNA played an important role in inducing the increase of blood pressure, potentially by altering expression of host cell genes that are involved in expression of pro-inflammatory cytokines, renin and Ang II, affecting vessel cell function and resulting in an increase of blood pressure.


Regulation (involved) of Gene_expression (expression) of renin in blood associated with pressure and volume under development, inflammation, cytomegalovirus infection, infection and cytokine
5) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.04 Pain Relevance 0.10

General Comments

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