INT16284

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.39
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
blood 2
nucleus accumbens 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
substance P 3 99.48 Very High Very High Very High
narcan 6 99.08 Very High Very High Very High
Pain 4 94.84 High High
Nucleus accumbens 4 93.94 High High
Dopamine 2 92.88 High High
Neurotransmitter 2 89.96 High High
antagonist 1 88.80 High High
Raphe 2 88.24 High High
Thalamus 2 84.64 Quite High
Disease Link Frequency Relevance Heat
Pain 3 94.84 High High
Stress 2 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that: 1) Injection of TRH into the nucleus accumbens resulted in a significant inhibition of pain discharges from PEN in nucleus parafascicularis, while injection of TRH into nucleus amygdalae, nucleus caudatus exerted no significant effect. 2) Pretreatment with atropine abolished the above-mentioned effect of TRH. 3) Pretreatment with haloperidol also abolished the above-mentioned inhibitory effect of TRH. 4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH.
Negative_regulation (abolished) of Negative_regulation (effect) of TRH in nucleus accumbens associated with pain, nucleus accumbens and narcan
1) Confidence 0.43 Published 1991 Journal J. Tongji Med. Univ. Section Abstract Doc Link 1819028 Disease Relevance 0.25 Pain Relevance 0.55
The attenuation of thyrotropin (TSH) responsiveness to a second injection of thyrotropin-releasing hormone (TRH) was studied in adult female rats.
Negative_regulation (attenuation) of Negative_regulation (attenuation) of TRH
2) Confidence 0.43 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6403887 Disease Relevance 0.07 Pain Relevance 0.07
The attenuation of thyrotropin (TSH) responsiveness to a second injection of thyrotropin-releasing hormone (TRH) was studied in adult female rats.
Negative_regulation (attenuation) of Negative_regulation (injection) of thyrotropin-releasing hormone
3) Confidence 0.43 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6403887 Disease Relevance 0.07 Pain Relevance 0.07
Pretreatment with naloxone methyl bromide (Br-naloxone), a quaternary naloxone derivative, which does not cross the blood-brain barrier, had no effect on the PRL response to beta EP but prevented the conjugated effect of beta EP and TRH on PRL secretion.
Negative_regulation (prevented) of Negative_regulation (effect) of TRH in blood associated with narcan
4) Confidence 0.40 Published 1987 Journal Life Sci. Section Abstract Doc Link 3104708 Disease Relevance 0 Pain Relevance 0.47
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Negative_regulation (decreased) of Negative_regulation (levels) of TRH associated with serotonin and substance p
5) Confidence 0.18 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.60

General Comments

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