INT162871

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 0.61
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
CFU-E 4
CFU-GM 2
melanocytes 1
pigmentation 1
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 108 100.00 Very High Very High Very High
cva 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 49 81.12 Quite High
Apoptosis 90 78.40 Quite High
Metastasis 11 62.16 Quite High
Stress 11 41.12 Quite Low
Death 32 34.20 Quite Low
Melanoma 2 13.20 Low Low
Anaemia 84 5.00 Very Low Very Low Very Low
Embryonic Lethality 48 5.00 Very Low Very Low Very Low
Calcification 36 5.00 Very Low Very Low Very Low
Osteoporosis 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sequences from ten species of Mus (Rodentia, Muridae) of the melanocortin-1 receptor (Mc1r) gene (945 bp), which plays a key role in coat color determination, were compared with an existing Mc1r dataset (ca. 498 bp) from 12 species of Mustela and Martes (Carnivora, Mustelidae).
Localization (dataset) of melanocortin-1 receptor associated with melanocortin 1 receptor
1) Confidence 0.75 Published 2009 Journal Genes Genet. Syst. Section Abstract Doc Link 19745571 Disease Relevance 0 Pain Relevance 0.37
Sequences from ten species of Mus (Rodentia, Muridae) of the melanocortin-1 receptor (Mc1r) gene (945 bp), which plays a key role in coat color determination, were compared with an existing Mc1r dataset (ca. 498 bp) from 12 species of Mustela and Martes (Carnivora, Mustelidae).
Localization (dataset) of Mc1r associated with melanocortin 1 receptor
2) Confidence 0.75 Published 2009 Journal Genes Genet. Syst. Section Abstract Doc Link 19745571 Disease Relevance 0 Pain Relevance 0.37
Of the 50 F2 progeny with the lightest dorsal pigmentation, 42 had at least one light Mc1r allele (LL or LD Mc1r genotypes; ?
Localization (allele) of Mc1r in pigmentation associated with melanocortin 1 receptor
3) Confidence 0.75 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.37
Sequences from ten species of Mus (Rodentia, Muridae) of the melanocortin-1 receptor (Mc1r) gene (945 bp), which plays a key role in coat color determination, were compared with an existing Mc1r dataset (ca. 498 bp) from 12 species of Mustela and Martes (Carnivora, Mustelidae).
Localization (dataset) of Mc1r associated with melanocortin 1 receptor
4) Confidence 0.66 Published 2009 Journal Genes Genet. Syst. Section Abstract Doc Link 19745571 Disease Relevance 0 Pain Relevance 0.36
For example, L-type prostaglandin D2 synthase (Ptgds) is expressed at high levels in pigment cells [68] and is repressed in Mc1re/Mc1re skin (current data, [49]); prostaglandin D2 and its derivatives could be one of several mediators released from Mc1r-competent melanocytes that facilitate or potentiate p53 phosphorylation in surrounding cells [69].
Localization (released) of Mc1r in melanocytes
5) Confidence 0.65 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.61 Pain Relevance 0.25
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of CFU-E in BFU-E
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of BFU-E in BFU-E
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of BFU-E in CFU-GM
8) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of BFU-E in CFU-E
9) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of CFU-E in CFU-E
10) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0
Single cell suspensions cultured in methylcellulose showed that the absolute number of CFU-E, BFU-E, CFU-GM and CFU-GEMM colonies per PiT1?
Localization (number) of CFU-E in CFU-GM
11) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0 Pain Relevance 0

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