INT16290

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1991
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 60
Total Number 63
Disease Relevance 38.73
Pain Relevance 32.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BSG) small molecule metabolic process (BSG) plasma membrane (BSG)
Anatomy Link Frequency
monocytes 9
synovium 9
blood 8
synovial fluid 4
macrophages 3
BSG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4220 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
rheumatoid arthritis 4105 99.84 Very High Very High Very High
spinal inflammation 810 99.62 Very High Very High Very High
Inflammation 220 99.62 Very High Very High Very High
Osteoarthritis 437 99.48 Very High Very High Very High
Enkephalin 2 98.28 Very High Very High Very High
antagonist 55 91.64 High High
Intracerebroventricular 2 80.76 Quite High
Pain 5 67.04 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4106 99.84 Very High Very High Very High
Pancreatic Cancer 29 99.80 Very High Very High Very High
Low Back Pain 810 99.62 Very High Very High Very High
INFLAMMATION 274 99.62 Very High Very High Very High
Frailty 486 99.48 Very High Very High Very High
Atherosclerotic Plaque 54 98.08 Very High Very High Very High
Breast Cancer 3 97.92 Very High Very High Very High
Cancer 368 97.40 Very High Very High Very High
Metastasis 11 95.44 Very High Very High Very High
Hepatocellular Cancer 108 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The difference between CD147 expression on monocytes in peripheral blood before and after stimulation in the control and RA groups was calculated with a LSD t-test.
Gene_expression (expression) of CD147 in blood associated with rheumatoid arthritis
1) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.32 Pain Relevance 0.22
The MFI of CD147 expression on the CD14+ monocytes in RA synovial fluid was higher than that in RA peripheral blood.
Gene_expression (expression) of CD147 in blood associated with rheumatoid arthritis
2) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 1.15 Pain Relevance 0.74
THP-1 cells were used because of their high expression of CD147 shown in previous reports [7] and our own experiments (data not shown).
Gene_expression (expression) of CD147 in THP-1
3) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.36 Pain Relevance 0.75
These results indicate that the upregulation of CD147 expression on monocytes is possibly associated with the pathogenesis of RA and CD147 may play an important role in the cartilage and bone destruction of RA.
Gene_expression (expression) of CD147 in cartilage associated with rheumatoid arthritis
4) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.79 Pain Relevance 0.50
Immunohistochemical staining shows that CD147 expression in RA synovium correlated with matrix metalloproteinase (MMP)-1 expression.
Gene_expression (expression) of CD147 in synovium associated with metalloproteinase and rheumatoid arthritis
5) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 1.13 Pain Relevance 0.74
In our study, the results of flow cytometry reveal that the mean fluorescence intensity (MFI) of CD147 expression on CD14+ monocytes of peripheral blood from RA patients was higher than that in normal control and ankylosing spondylitis (AS) patients.
Gene_expression (expression) of CD147 in blood associated with spinal inflammation and rheumatoid arthritis
6) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 1.13 Pain Relevance 0.67
The expression of CD147 correlated significantly with that of MMP-1 (p < 0.05), but the expression of CD147 and MMP-1 did not correlate with that of TIMP-1 (p > 0.05) (Table 1).
Gene_expression (expression) of CD147 associated with metalloproteinase
7) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.94 Pain Relevance 1.03
CD147 was expressed predominantly on the macrophage-like cells and fibroblast-like synovial cells in the lining and sublining layers (Fig. 2).
Gene_expression (expressed) of CD147 in fibroblast
8) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 1.15 Pain Relevance 1.07
The difference between CD147 expression on monocytes from peripheral blood and synovial fluid in the RA and AS groups was calculated with a Student's t-test.
Gene_expression (expression) of CD147 in synovial fluid associated with spinal inflammation and rheumatoid arthritis
9) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.38 Pain Relevance 0.34
To confirm the expression of CD147 in synovium and to characterize the CD147 expressing cells, immunohistochemical staining and immunofluorescence were performed.
Gene_expression (expressing) of CD147 in synovium
10) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.76 Pain Relevance 0.50
The upregulation of CD147 expression on monocytes/macrophages suggests that CD147 may be important in both the autocrine and paracrine stimulation of MMP expression.
Gene_expression (expression) of CD147 in macrophages associated with metalloproteinase
11) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.61 Pain Relevance 0.45
The immunoreactivity of CD147 was more intense and more widespread in RA synovium than in OA and AS synovium, and the expression of CD147 correlated with MMP-1 expression.
Gene_expression (expression) of CD147 in synovium associated with spinal inflammation, metalloproteinase, rheumatoid arthritis and osteoarthritis
12) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.81 Pain Relevance 0.56
Expression of CD147, MMP-1 and TIMP-1 on synovium from RA patients and control
Gene_expression (Expression) of CD147 in synovium associated with rheumatoid arthritis and metalloproteinase
13) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 1.16 Pain Relevance 0.98
A double immunofluorescent assay shows that CD147 was expressed on CD68+ cells in RA synovium.
Gene_expression (expressed) of CD147 in synovium associated with rheumatoid arthritis
14) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257431 Disease Relevance 1.08 Pain Relevance 0.78
To confirm the expression of CD147 in synovium and to characterize the CD147 expressing cells, immunohistochemical staining and immunofluorescence were performed.
Gene_expression (expression) of CD147 in synovium
15) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.76 Pain Relevance 0.49
The expression of CD147 correlated significantly with that of MMP-1 (p < 0.05), but the expression of CD147 and MMP-1 did not correlate with that of TIMP-1 (p > 0.05) (Table 1).
Gene_expression (expression) of CD147 associated with metalloproteinase
16) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.97 Pain Relevance 1.04
In the AS group, the MFI of CD147 expression on CD14+ cells of synovial fluid (154.76 ± 27.74) was also higher than that in peripheral blood (61.77 ± 15.59, p < 0.01).


Gene_expression (expression) of CD147 in blood associated with spinal inflammation
17) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 1.10 Pain Relevance 0.91
Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production

Monocytes/macrophages play an important role in rheumatoid arthritis (RA) pathogenesis.

Gene_expression (Expression) of CD147 in monocyte associated with metalloproteinase and rheumatoid arthritis
18) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1257431 Disease Relevance 1.04 Pain Relevance 0.62
These results are in part consistent with some previous reports [12,13], but our immunohistochemical staining and immunofluorescence results further confirmed that CD147 is expressed in synovium not only on the fibroblast-like cells and granulocytes, but also on the CD68+ macrophage-like cells, which are believed to be peripheral monocyte-derived.
Gene_expression (expressed) of CD147 in granulocytes
19) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.76 Pain Relevance 0.50
The difference between CD147 expression on monocytes in the peripheral blood before stimulation in the control and RA groups was calculated with ANOVA.
Gene_expression (expression) of CD147 in monocytes associated with rheumatoid arthritis
20) Confidence 0.68 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257431 Disease Relevance 0.36 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox